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Atorvastatin

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Identification
Molecular formula
C33H35FN2O5
CAS number
134523-03-8
IUPAC name
7-[8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid
State
State

Atorvastatin is typically a solid at room temperature with a crystalline structure.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
558.65g/mol
Molar mass
558.6460g/mol
Density
1.2000g/cm3
Appearence

Atorvastatin is commonly found as a white to off-white crystalline powder.

Comment on solubility

Solubility of 7-[8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid

The solubility of the compound with the formula C33H35FN2O5 can be quite complex due to its intricate structural makeup. Understanding solubility involves several factors:

  • Polarity: The presence of hydroxyl groups (–OH) in the structure typically enhances solubility in polar solvents, particularly water.
  • Hydrophobic Regions: The bulky hydrophobic segments from the hexahydronaphthalene components may hinder solubility in water but improve compatibility with non-polar organic solvents.
  • Functional Groups: The carboxylic acid component may also affect solubility, as it can form hydrogen bonds with water, contributing to increased solubility in aqueous solutions.

In general, it is expected that:

  1. This compound may exhibit better solubility in organic solvents such as ethanol or acetone due to its hydrophobic characteristics.
  2. It may demonstrate a limited solubility in water, depending on the concentration of the hydroxyl groups relative to the hydrophobic components.

Overall, the solubility profile for this compound is likely a balance between its hydrophilic and hydrophobic parts, requiring empirical testing for precise determination. Thus, it is essential to explore its solubility under various conditions to fully understand its behavior in different environments.

Interesting facts

Interesting Facts about 7-[8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxy-heptanoic acid

This compound, a sophisticated organic molecule, presents an intriguing blend of structure and function that piques the interest of chemists and biochemists alike. Its unique architecture involves a hexahydronaphthalene core adorned with various functional groups, highlighting the remarkable versatility often found in organic synthesis.

Key Features:

  • Complex Structure: The combination of a hexahydronaphthalenic scaffold and multiple hydroxyl groups makes this compound an interesting subject for studies in molecular interactions and reactivity.
  • Therapeutic Potential: Compounds such as this often exhibit interesting biological activities, where modifications can lead to enhanced pharmacological effects.
  • Synthetic Chemistry: The construction of such a large and complex molecule typically involves advanced synthetic techniques, illustrating the creativity and precision required in modern organic chemistry.

Moreover, based on its structural components, one could envision its application in the field of medicinal chemistry, particularly in drug delivery systems or as a precursor for developing therapeutic agents. The incorporation of hydrophilic and lipophilic segments within its structure can enhance bioavailability and effectiveness, creating exciting opportunities for further research.

As described by chemists, "The fusion of nature and synthetic methodologies opens new pathways in designing compounds that mirror the complexity of biological systems." Exploring the properties and potential applications of this compound could lead to significant advancements in both theoretical knowledge and practical applications in the chemical sciences.

Synonyms
7-{8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl}-3,5-dihydroxyheptanoic acid
1394115-93-5
SCHEMBL3694911
DTXSID00869659
1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-?,?-dihydroxy-2,6-dimethyl-, (?R,?R,1S,2S,6R,8S,8aR)-