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Aclarubicin

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Identification
Molecular formula
C42H53NO15
CAS number
57576-44-0
IUPAC name
7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
State
State

At room temperature, aclarubicin is typically found as a solid substance, often in the form of a lyophilized powder, which is used for pharmaceutical formulations.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
852.87g/mol
Molar mass
852.8660g/mol
Density
1.3505g/cm3
Appearence

Aclarubicin appears as a dark red to reddish-brown powder or crystalline substance. It is highly hygroscopic and sensitive to light. It is usually encountered in the form of a lyophilized powder for medicinal use.

Comment on solubility

Solubility of 7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione (C42H53NO15)

The solubility of a compound is a vital characteristic that defines its behavior in various solvents and environments. For the compound C42H53NO15, understanding its solubility can be quite intricate due to its complex structure. Here are some critical points to consider regarding its solubility:

  • Polarity: The presence of multiple hydroxyl groups (-OH) within its structure suggests that the compound may exhibit hydrophilic properties, potentially enhancing its solubility in water.
  • Functional Groups: The amino and methoxy groups also influence solubility. Generally, compounds with amino groups tend to be more soluble in polar solvents.
  • Solvent Interaction: The solubility in organic solvents can vary significantly. For instance, the aromatic nature of the tetracene derivative suggests possible solubility in non-polar solvents such as hexane or toluene, although this may decrease due to the larger polar substituents.
  • Concentration and Temperature: Like many organic compounds, solubility can be affected by concentration and temperature. Increased temperature can often enhance solubility, making it crucial to consider these factors in practical applications.

In summary, while it seems that C42H53NO15 may have a tendency to be soluble in polar solvents due to its hydroxyl and amino functionalities, the overall solubility behavior could be quite variable depending on specific conditions and the choice of solvent.

Interesting facts

Interesting Facts about 7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

This compound, a complex derivative of tetracene, is of significant interest in both organic chemistry and materials science due to its intriguing structural features and potential applications. Here are some notable points:

  • Structure Complexity: The compound features several functional groups including amino, hydroxy, and methoxy groups which are responsible for its chemical reactivity and potential biological activity.
  • Potential Biological Applications: With its rich array of hydroxyl groups, this compound may exhibit interesting interactions in biological systems, potentially acting as a scaffold for drug development or as a probe in biological studies.
  • Optoelectronic Properties: As a derivative of tetracene, it is expected to show remarkable photophysical properties, which could be harnessed in organic electronic devices, such as organic light-emitting diodes (OLEDs) or organic solar cells.
  • Synthetic Pathways: The synthesis of such complex molecules often involves several steps, highlighting the ingenuity required in organic synthesis and the use of protective groups and selective reactions.
  • Multifunctionality: The presence of multiple hydroxy groups can provide sites for further functionalization, allowing chemists to tailor the compound's properties for specific applications.

As a scientist studying this compound, one might reflect on the words of chemist Linus Pauling: "The best way to have a good idea is to have lots of ideas." The intricate structure of this compound certainly presents a wealth of ideas for further exploration and application in various fields.

In conclusion, the study of 7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione not only underscores the beauty of organic chemistry but also points towards exciting future directions in research and technology.

Synonyms
Triferric doxorubicin
NSC169534
GNF-Pf-2453
NSC-169534
5, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-, mixt. with native calf thymus DNA
ADR (Salt/Mix)
FI-106
Adriamycin Fe3Cl10 H
DOX HCl (Salt/Mix)
Neuro_000057
Neuro_000121
Adriamycin-DNA hydrochloride
7-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
SCHEMBL233853
CHEMBL263733
CHEBI:91872
AOJJSUZBOXZQNB-UHFFFAOYSA-N
(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
ADM
Adriamycin hydrochloride (Salt/Mix)
Doxorubicin hydrochloride (Salt/Mix)
MFCD00869292
NSC267703
NSC272332
NSC272707
NSC272708
NSC302662
NSC303830
NSC303831
NSC307242
NSC307243
NSC321796
STK397071
STL484194
AKOS005434002
NSC-272332
NSC-272707
NSC-272708
NSC-302662
NSC-303830
NSC-303831
NSC-307242
NSC-307243
NSC-321796
SY224845
BRD-A76941896-001-01-6
BRD-A76941896-003-01-2
BRD-A76941896-003-02-0
Q27163668
(8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
3,6,11-trihydroxy-3-(hydroxyacetyl)-10-methoxy-5,12-dioxo-1,2,3,4,5,12-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside
3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-L-lyxo-hexopyranoside, (1S,3S)-
3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-naphthacenyl 3-amino-2,3,6-trideoxyhexopyranoside
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
7-[(4-amino-5-hydroxy-6-methyl-2-oxanyl)oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
Dextran,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
Ferrate (1-),3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione]decachlorotri-, hydrogen, (8S-cis)
Ferrate(1-),3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione]decachlorotri-, hydrogen, (8S-cis)-
Nucleic acid, sodium salt, compound with (8S-cis)-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride