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Abacavir

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Identification
Molecular formula
C14H18N6O
CAS number
136470-78-5
IUPAC name
7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
State
State

Abacavir is typically a solid at room temperature and is used as a medication in the form of tablets or oral solution.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
365.00
Boiling point (Kelvin)
638.15
General information
Molecular weight
286.33g/mol
Molar mass
286.3310g/mol
Density
1.3700g/cm3
Appearence

Abacavir is a white to off-white solid powder that is very slightly soluble in water. It is usually provided in a crystalline form.

Comment on solubility

Solubility of 7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one (C14H18N6O)

The solubility of 7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one exhibits interesting properties that stem from its complex structure. Understanding its solubility can reveal valuable information about its potential applications in various environments. Key points regarding the solubility of this compound include:

  • Polar components: The presence of multiple hydroxyl (-OH) groups within the molecular structure indicates a tendency for hydrogen bonding, which generally enhances solubility in polar solvents such as water.
  • Non-polar characteristics: The hydrophobic regions in the compound may lead to decreased solubility in highly non-polar solvents, creating a balance between polar and non-polar interactions.
  • pH Sensitivity: The solubility can be influenced by pH levels, especially due to the amine functionalities that may become protonated, thereby increasing solubility in acidic environments.

This compound's solubility characteristics emphasize the importance of considering environmental factors when determining its behavior in different solutions. Comprehensive studies on the solubility of such compounds are crucial for understanding their biological and chemical reactivity.

Interesting facts

Interesting Facts about 7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one

This intriguing compound is a member of the pyrrolopyrimidine class, which is known for its biological significance and diverse applications in medicinal chemistry. Below are some fascinating aspects of this compound:

  • Biological Activity: Many compounds within the pyrrolopyrimidine family, including this one, exhibit notable biological activities, often functioning as potent inhibitors for various enzymes and receptors.
  • Potential Drug Development: Compounds similar to this one have shown promise in drug development processes, particularly in targeting cancer and other disease pathways due to their ability to modulate cellular functions.
  • Sugar Moiety: The incorporation of a sugar-like structure, specifically the tetrahydrofuran unit in this compound, enhances solubility and bioavailability, which are crucial for pharmacological efficacy.
  • Structure-Activity Relationship (SAR): The distinct functional groups present, such as the hydroxymethyl and hydroxyl groups, contribute to the overall reactivity and selectivity of the compound, making it a key target in SAR studies.
  • Versatile Functionalization: The presence of multiple functional groups allows for possible modifications, which can help in fine-tuning the compound's therapeutic profile and reducing side effects.

In conclusion, the structural complexity and potential biological roles of 7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one make it a fascinating subject of study in the realms of organic and medicinal chemistry. With ongoing research, compounds like this could lead to the discovery of novel therapeutic agents.