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Montelukast

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Identification
Molecular formula
C35H36ClNO3S
CAS number
151767-02-1
IUPAC name
7-[3-[[2-(phenylcarbamoyl)hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
State
State

At room temperature, montelukast is typically in a solid state manifesting as a powder.

Melting point (Celsius)
137.00
Melting point (Kelvin)
410.15
Boiling point (Celsius)
130.00
Boiling point (Kelvin)
403.15
General information
Molecular weight
586.18g/mol
Molar mass
608.1840g/mol
Density
1.2456g/cm3
Appearence

Montelukast is a white to off-white powder. It is practically insoluble in water and freely soluble in ethanol, methanol, and dimethyl sulfoxide.

Comment on solubility

Solubility of 7-[3-[[2-(phenylcarbamoyl)hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid (C35H36ClNO3S)

The solubility of the compound 7-[3-[[2-(phenylcarbamoyl)hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid can be intriguing given its complex structure. Understanding its solubility profile reveals important insights into its behavior in various solvents:

  • Polar vs. Non-Polar Solvents: This compound may exhibit unique solubility characteristics in polar solvents such as water, methanol, and ethanol due to its hydrophilic functional groups, while being less soluble in non-polar solvents.
  • pH Dependency: The solubility can also be influenced by the pH of the solution, as acidic or basic conditions can alter the ionization of functional groups, potentially increasing solubility.
  • Temperature Influence: Temperature may play a significant role; generally, an increase in temperature can enhance solubility for many organic compounds.
  • Concentration and Solid State: The compound's crystalline form affects its solubility; modifications in purity and particle size can lead to variations in how well it dissolves.

As noted in the literature, “the solubility of a compound is not just a trivial property but a fundamental aspect that influences its applications.” This underscores the necessity to evaluate the solubility in specific contexts, especially when considering formulations or biological interactions.

In summary, while specific solubility data for this compound may be limited, its overall behavior can be anticipated through careful analysis of the factors mentioned above.

Interesting facts

Interesting Facts about 7-[3-[[2-(phenylcarbamoyl)hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid

This compound is a fascinating example of organic chemistry due to its complex structure and potential applications. Here are some intriguing aspects:

  • Structural Complexity: This compound features a bicyclic framework, which is significant in medicinal chemistry as it can mimic natural compounds found in biological systems.
  • Pharmacological Potential: The presence of the phenylcarbamoyl and hydrazino functional groups hints at possible biological activities, making it a candidate for drug development. Many hydrazone derivatives show promising results in anticancer and antimicrobial research.
  • Synthetic Challenges: Synthesis of such a complex structure often involves multiple steps and challenges. Creative strategies and advanced techniques in organic synthesis are required, showcasing the ingenuity of chemists.
  • Multi-functional Groups: The integration of various functional groups, such as carboxylic acids and amines, allow for extensive chemical modifications, which can lead to the development of novel derivatives with enhanced properties.
  • Historical Context: Compounds like this one are crucial in the evolution of synthetic drugs, illustrating how chemists explore and modify natural substances to improve therapeutic efficacy and minimize side effects.

As we continue to explore and understand such compounds, they serve as reminders of the intersection between chemistry and life sciences. The potential for new discoveries remains vast!

Synonyms
SQ-29548
98672-91-4
7-[3-[[2-(phenylcarbamoyl)hydrazinyl]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
KBioGR_000248
KBioSS_000248
KBio2_000248
KBio2_002816
KBio2_005384
KBio3_000495
KBio3_000496
Bio2_000248
Bio2_000728
7-(3-((2-((Phenylamino)carbonyl)hydrazino)methyl)-7-oxabicyclo(2.2.1)hept-2-yl)-5-heptenoic acid
98299-61-7
Q27163752
7-[3-[[[anilino(oxo)methyl]hydrazo]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]-5-heptenoic acid