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Cefaclor

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Identification
Molecular formula
C15H14ClN3O4S
CAS number
53994-73-3
IUPAC name
7-[(2-amino-2-phenyl-acetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
State
State

At room temperature, Cefaclor is typically a solid.

Melting point (Celsius)
177.00
Melting point (Kelvin)
450.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
367.81g/mol
Molar mass
367.8000g/mol
Density
1.6400g/cm3
Appearence

Cefaclor is a white to off-white crystalline powder.

Comment on solubility

Solubility of 7-[(2-amino-2-phenyl-acetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (C15H14ClN3O4S)

This compound presents an intriguing solubility profile due to its unique structural components. Understanding its solubility is vital for applications in pharmaceuticals and biochemistry. Here are some key insights:

  • Polarity: The presence of various functional groups—including carboxylic acid, amine, and chlorine—suggests a level of polarity that may enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The amino and carboxylic acid groups can engage in hydrogen bonding, which may significantly improve solubility in aqueous solutions.
  • pH Dependence: The solubility may vary with pH; for instance, at low pH, the carboxylic acid group may remain protonated, potentially affecting solubility dynamics.
  • Solvent Compatibility: While it may be soluble in aqueous media, solubility in organic solvents (like ethanol or DMSO) could differ; explorations are necessary for a comprehensive understanding.

In conclusion, the solubility of this compound is influenced by its structural features and environmental factors. Further experimentation and analysis will provide a clearer picture of its behavior in different solvents and conditions, paving the way for effective utilization.

Interesting facts

Interesting Facts about 7-[(2-amino-2-phenyl-acetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

This intriguing compound is a member of a class of chemical substances known for their biological activities. It is primarily studied for its potential pharmacological properties, making it an essential subject of research in medicinal chemistry. Here are some fascinating aspects about this compound:

  • Pharmaceutical Applications: The compound has drawn attention for its possible efficacy in treating bacterial infections, similar to other antibiotics. Its unique structure enables it to interact with bacterial ribosomes.
  • Structure-Activity Relationship (SAR): Understanding how the variations in its chemical structure affect its activity is vital for the design of new derivatives that could exhibit improved potency and reduced side effects.
  • Thiazole Moiety: The presence of the thiazole ring plays a crucial role in its biological activity, contributing to the overall stability and reactivity of the molecule.
  • Mechanism of Action: Research indicates that the compound may inhibit bacterial growth by interfering with protein synthesis, providing a pathway for the development of new antibiotics.

The exploration of this compound’s properties and behaviors opens up a world of possibilities for novel therapeutic agents. As experiments continue, scientists aim to enhance efficacy while minimizing potential risks associated with its use. The ongoing research reflects the compound's importance in the larger context of antibiotic discovery and development.

Synonyms
Lilly 99638
Cefaclor Impurity C
7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cefaclor [anhydrous]
SCHEMBL6155629
CHEMBL1474918
GTPL10897
DTXSID80860664
HMS3369E17
HMS3394C11
BCP27696
NCGC00015260-03
NCGC00015260-04
NCGC00094850-01
NCGC00094850-02
SY247820
Ceclor; S 6472; S-6472;S6472
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6alpha,7beta(R*)))-
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, [6R-[6.alpha.,7.beta.(R*)]]-
7-([Amino(phenyl)acetyl]amino)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid #
7-[(aminophenylacetyl)amino]-3-[chloro]-8-oxo-5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid
7-[2-Amino(phenyl)acetamido]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid