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Amoxicillin

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Identification
Molecular formula
C16H19N3O5S
CAS number
26787-78-0
IUPAC name
7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
State
State

At room temperature, amoxicillin exists as a solid. It is most commonly encountered in the form of capsules or tablets for oral administration. Amoxicillin is water-soluble, allowing it to be used in various aqueous formulations as well.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
3.00
Boiling point (Kelvin)
3.00
General information
Molecular weight
365.41g/mol
Molar mass
365.4050g/mol
Density
1.6000g/cm3
Appearence

Amoxicillin typically appears as a white to off-white crystalline powder. It is usually supplied in the form of a trihydrate that can exist in amorphous or crystalline form. The crystalline powder may have a mild odor.

Comment on solubility

Solubility of 7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

This compound, with the chemical formula C16H19N3O5S, presents a unique solubility profile that is largely influenced by its complex structure. Generally, the solubility of such compounds can be assessed based on the following factors:

  • Functional Groups: The presence of various functional groups such as amino, hydroxyl, and carboxylic acid enhances hydrophilicity, potentially increasing water solubility.
  • Polarity: The overall polarity of the molecule, which is determined by the arrangement of electronegative atoms, plays a crucial role in its solubility in polar solvents.
  • Hydrogen Bonding: Molecules capable of forming hydrogen bonds tend to have improved solubility in water compared to non-hydrogen bonding molecules.

As a result, it's anticipated that this compound exhibits a moderate to high solubility in aqueous solutions, which can be particularly useful in pharmaceutical applications where drug bioavailability is a key consideration. However, detailed solubility studies would provide more definitive insights into its behavior in various solvents.

In conclusion, while the specific solubility constant is not provided here, factors such as structure, functional groups, and intermolecular interactions are critical in determining how this compound will behave in different chemical environments.

Interesting facts

Interesting Facts about 7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

This compound is a fascinating example of a complex molecule that showcases the intricate beauty of medicinal chemistry. Here are several interesting aspects to consider:

  • Structural Complexity: The molecule features a bicyclic structure, which is indicative of how nature creates diverse chemical scaffolds. This specific arrangement allows for various interactions with biological targets, making it an interesting subject in drug design.
  • Potential Biological Activity: Compounds like this one are often investigated for their potential as pharmaceutical agents. The presence of a thia (sulfur-containing) ring and an amino acid moiety suggests that it may have unique mechanisms of action, particularly against bacterial infections.
  • Role of Hydroxy Groups: The hydroxyphenyl group in the structure contributes to the compound's biological activity. Hydroxyl groups can interact with enzymes and receptors through hydrogen bonding, potentially enhancing therapeutic effects.
  • Importance in Drug Development: The compound embodies the typical features of many antibiotics, making it crucial in ongoing research to combat antibiotic resistance. As scientists investigate new derivatives, there’s a continuous effort to optimize efficacy and minimize side effects.

In conclusion, much like a puzzle waiting to be solved, this compound's structure offers a window into the intricate world of biochemical interactions. As chemists and students delve deeper into such molecules, they uncover new possibilities for innovative therapies.

Synonyms
Oracefal
1181570-19-3
7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
BL-S 578
7-((2-Amino-2-(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
CHEMBL1555813
SCHEMBL13698957
DTXSID90860610
NCGC00094609-01
NCGC00094609-02
AS-13773
DB-051762
EN300-23549743
7-[2-Amino(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid