Skip to main content

Atorvastatin

ADVERTISEMENT
Identification
Molecular formula
C33H35FN2O5
CAS number
134523-00-5
IUPAC name
7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid
State
State

Atorvastatin is typically a solid at room temperature in its pure form.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
205.00
Boiling point (Kelvin)
478.15
General information
Molecular weight
558.64g/mol
Molar mass
558.6440g/mol
Density
1.2000g/cm3
Appearence

Atorvastatin usually appears as a white to off-white crystalline powder. Its exact appearance can depend on how it's processed, but it typically has a fine crystalline texture.

Comment on solubility

Solubility of 7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid

The solubility of the compound C33H35FN2O5 can be quite intricate due to its complex structure. This molecule, featuring multiple functional groups such as hydroxyls and a fluorophenyl moiety, suggests that solubility can vary significantly depending on the solvent. Here are some points to consider:

  • Hydrophilic Characteristics: The presence of dihydroxy groups may contribute to solubility in polar solvents, particularly in water.
  • Hydrophobic Regions: The long aliphatic chain and various phenyl groups indicate poor solubility in polar solvents, making organic solvents like ethanol or dimethyl sulfoxide (DMSO) more favorable.
  • Influence of Fluorine: The fluorophenyl part can impact solubility and partitioning behavior, potentially enhancing lipophilicity.
  • pH Sensitivity: The acid functional group may affect solubility under different pH conditions, exhibiting better solubility in either acidic or basic media depending on the ionization state.

In summary, the solubility of this compound is expected to be influenced by its unique molecular composition, leading to diverse solubility characteristics based on the medium used. Understanding these solubility properties is essential for applications in pharmaceuticals and material science.

Interesting facts

Interesting Facts about 7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid

This intriguing compound, known for its complex structure and diverse applications, presents a wealth of fascinating characteristics that captivate both chemists and biologists alike.

Pharmacological Significance

One of the standout features of this compound is its potential in medicinal chemistry. Its unique structure allows it to interact with biological systems in novel ways. Here are some key points:

  • Anticancer Activity: Preliminary studies suggest that compounds like this one may possess anticancer properties, making them a subject of interest in tumor research.
  • Targeted Treatment: With its complex targeting ability, it holds promise for selective interaction with certain types of cancer cells.

Chemical Structure Features

The intricate molecular architecture of this compound incorporates various functional groups that offer unique reactivity:

  • Fluorine Atom: The presence of fluorine enhances bioactivity, potentially impacting the pharmacokinetics.
  • Pyrrole Ring: This five-membered ring is notable for its stability and versatility in forming biological compounds.
  • Multiple Hydroxy Groups: The dihydroxy structure suggests applications in areas such as antioxidant activities.

Research Interest

Chemists and biochemists are particularly interested in this compound due to its multi-functional capabilities. As researchers delve into the potential modifications of its structure, they may discover:

  • New Derivatives: There is ample opportunity for synthesis of derivatives that could exhibit enhanced therapeutic efficacy or reduced side effects.
  • Mechanism of Action: Understanding how this compound interacts at the molecular level can lead to breakthroughs in drug design.

In conclusion, the study of 7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid is a testament to the intricate interplay between chemistry and biology. With ongoing research, this compound could pave the way for groundbreaking treatments in pharmacology.

Synonyms
Atorvastatin(Relative)
110862-48-1
842103-12-2
7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3S,5R)-atorvastatin
Atorvastatin EP Impurity B
MLS006011909
SCHEMBL537781
CHEBI:94450
BCP22976
STL301805
AKOS022101059
FF59474
IA182307
LS-15342
SMR004703512
DS-012595
BRD-A82307304-001-01-8
Q27166314
(3R,5R)-7-[2-(4-FLUOROPHENYL)-3-PHENYL-4-(PHENYLCARBAMOYL)-5-PROPAN-2-YL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (?R,?R)-
2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid
7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
7-[4-[anilino(oxo)methyl]-2-(4-fluorophenyl)-3-phenyl-5-propan-2-yl-1-pyrrolyl]-3,5-dihydroxyheptanoic acid