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Coenzyme A

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Identification
Molecular formula
C21H36N7O16P3S
CAS number
85-61-0
IUPAC name
7-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxo-heptanoic acid
State
State

At room temperature, coenzyme A is typically found as a solid in its pure form. It is usually handled as a powder or crystalline solid.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
767.53g/mol
Molar mass
767.5340g/mol
Density
1.1200g/cm3
Appearence

Coenzyme A is a white to off-white crystalline powder. It is often supplied as a sodium or lithium salt, and it is hygroscopic, meaning it readily absorbs moisture from the air.

Comment on solubility

Solubility of 7-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxo-heptanoic acid

The solubility of the compound C21H36N7O16P3S can be described by considering a few essential aspects:

  • Hydrophilicity vs. Hydrophobicity: This compound contains multiple phosphono and hydroxy groups that enhance its hydrophilic character, which may facilitate solubility in aqueous environments.
  • Structural Complexity: The extensive structure includes both a purine base and a hydrophobic alkyl chain, which can lead to variances in solubility depending on the solution condition.
  • pH Dependence: The solubility may be influenced by the pH of the solution, as the presence of protonable functional groups (such as amino groups) can alter the molecular state, affecting solubility.
  • Salt Formation: The ability to form salts with various counterions might improve its solubility profile in certain solvents.

In conclusion, while the compound’s numerous functional groups suggest potential for high solubility in polar solvents, the actual solubility can vary significantly based on factors such as the solvent used, temperature, and pH. Testing in a specific context is crucial for understanding its solubility behavior.

Interesting facts

Interesting Facts about 7-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxo-heptanoic acid

This complex chemical compound is an intriguing example of biomolecular design featuring a variety of functional groups that can interact in unique ways. It is particularly noteworthy due to its role in biochemistry and pharmacology. Here are some key points about this fascinating compound:

  • Multifunctionality: The presence of multiple phosphonate and amino groups suggests that this compound may play a significant role in metabolic pathways, potentially serving as a substrate or co-factor in enzymatic reactions.
  • Diverse Structure: The structure incorporates a variety of components such as purines, amino acids, and phosphate groups, showcasing a rich chemistry often seen in nucleotides and their derivatives.
  • Biological Applications: Similar compounds are often explored for their potential medicinal properties, including antibacterial, antiviral, and anticancer activities, making them of great interest in pharmaceutical research.
  • Synthetic Challenges: The complexity of synthesizing this compound reflects the challenges chemists face when working with multi-functional molecules. The synthetic pathways often require advanced techniques to ensure the stability and reactivity of different functional groups.
  • Research Significance: The unique structure provides insights into biochemical processes, and ongoing studies may shed light on how these types of compounds interact with biological systems.

As a testament to its complexity, the name itself reveals the intricate arrangement of various chemical moieties. Understanding compounds like this not only enhances our knowledge of chemical interactions but also fuels innovation in drug design and development. In the words of renowned chemist Linus Pauling, “The best way to have a good idea is to have a lot of ideas.” This compound serves as a prime example of just how innovative and multifaceted chemical science can be.

Synonyms
SCHEMBL15984379