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Ceftriaxone

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Identification
Molecular formula
C18H18N8O7S3
CAS number
73384-59-5
IUPAC name
7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, ceftriaxone exists as a solid in the form of a crystalline powder. It is utilized in its powder form for reconstitution into an injectable solution.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.20
Boiling point (Celsius)
-189.35
Boiling point (Kelvin)
83.80
General information
Molecular weight
554.58g/mol
Molar mass
554.5820g/mol
Density
1.7900g/cm3
Appearence

Ceftriaxone appears as a white to yellowish crystalline powder. It is typically odorless and can be soluble in water, forming a clear solution.

Comment on solubility

Solubility of 7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (C18H18N8O7S3)

Understanding the solubility of this complex compound requires analyzing various factors that influence its interaction with solvents. Generally, solubility can be influenced by:

  • Polarity: The compound contains functional groups that can engage in hydrogen bonding, making it likely to show variable solubility in polar solvents such as water.
  • pH: Alterations in pH can affect the ionization of certain components within the compound, potentially enhancing or decreasing its solubility.
  • Temperature: Increasing temperature often enhances solubility, particularly for organic compounds, so testing at different temperatures may yield more insights.
  • Solvent type: The choice of solvent (polar vs. non-polar) can drastically affect solubility; this compound may find better solubility in organic solvents than in water.

In general, compounds of similar structure have shown variable solubility profiles based on these parameters. As stated in many studies, "the solubility behavior is as much about the molecular structure as it is about the environmental conditions." Hence, to gain a comprehensive understanding, it is advisable to perform solubility tests across a spectrum of solvents and conditions.

Overall, the solubility characteristics of this compound are expected to be complex and nuanced, requiring careful investigation to optimize usage in potential applications.

Interesting facts

Interesting Facts about 7-[[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound, known for its complex structure and distinctive features, represents a fascinating area of study in the field of medicinal chemistry. Here are some noteworthy points:

  • Pharmacological Potential: The compound is synthesized for its potential use in antibacterial and antifungal activities, with research indicating it may combat resistant strains of microorganisms.
  • Structural Complexity: The intricate bicyclic structure indicates a unique interaction potential with biological targets, which is vital for developing new therapeutic agents.
  • Amidino Group: The presence of the thiazole moiety contributes to electronic properties that can enhance binding interactions with active sites in pathogen targets.
  • Immunological Implications: Some studies suggest that compounds of this nature may also modulate immune responses, opening avenues for their use in immunotherapies.
  • Research and Development: As part of ongoing medicinal chemistry research, compounds similar to this one are being evaluated for efficacy and safety, showcasing the evolving landscape of drug discovery.

As highlighted by pioneering chemists, "The journey of a compound starts from the laboratory and extends into the realms of life-saving medicines." The continued exploration of compounds like this one exemplifies the fusion of chemistry, biology, and pharmacology in the quest to overcome medical challenges.

Through innovative research and collaboration, the study of such complex compounds holds promise for significant advancements in healthcare and drug formulation.