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ABT-199 (Venetoclax)

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Identification
Molecular formula
C45H50N7O4
CAS number
1257044-40-8
IUPAC name
7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine
State
State

Venetoclax is typically found as a solid at room temperature.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
499.15
Boiling point (Kelvin)
772.30
General information
Molecular weight
868.44g/mol
Molar mass
868.4410g/mol
Density
1.2954g/cm3
Appearence

Venetoclax appears as a white to off-white, crystalline powder. It is relatively stable under normal conditions and is practically insoluble in water but soluble in some organic solvents.

Comment on solubility

Solubility of 7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine

The solubility characteristics of 7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine (C45H50N7O4) can be understood by considering several factors:

  • Molecular Structure: The extensive carbon (C) and nitrogen (N) backbone along with the presence of functional groups contribute to its interactions with solvents.
  • Polarity: Due to its considerable size and specific functional groups, this compound is likely to exhibit a moderate polarity, influencing its solubility in different solvents.
  • Solvent Compatibility: It may show solubility in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Acetone
    • Chloroform
  • Water Solubility: Given its complex structure and probable large hydrophobic regions, it is expected that this compound is poorly soluble in water.
  • Temperature Influence: Solubility can also vary with temperature; generally, increased temperatures can lead to improved solubility in organic solvents.

In summary, *7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine* demonstrates selective solubility profiles that are typical for large organic compounds, emphasizing the importance of molecular structure in determining solubility.

Interesting facts

Interesting Facts about 7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine

7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine is a fascinating compound that intrigues chemists and pharmacologists alike, primarily due to its potential applications in medicinal chemistry. Below are some compelling insights about this unique compound:

  • Unique Structure: This compound features a complex aromatic structure that includes both a pyrrolo and a quinazoline moiety, which can influence its reactivity and biological activity. The presence of various functional groups in its structure contributes to diverse chemical properties.
  • Potential Biological Activity: Compounds with similar structural frameworks are often investigated for their pharmacological properties, including anticancer and antimicrobial activities. The presence of the amino groups suggests potential as enzyme inhibitors.
  • Design and Synthesis: The synthesis of pyrroloquinazolines presents interesting challenges. Chemists often employ multi-step synthetic routes to construct such intricate structures, requiring creativity and precision.
  • Research Interest: This particular compound is potentially of interest in drug discovery, with researchers exploring its impact on specific biological pathways. As such, it represents a candidate for further exploration in the quest for novel therapies.
  • Interdisciplinary Relevance: The study of such compounds often bridges chemistry, pharmacology, and biology, showing how advancements in one field can significantly impact others, especially in drug development.

In conclusion, 7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine captivates the interest of scientists for its complex structure and potential therapeutic effects. Continued exploration of this compound may lead to significant advancements in medicinal chemistry.

Synonyms
7-(1-ethyl-propyl)-7h-pyrrolo-[3,2-f]quinazoline-1,3-diamine
GW345
CHEMBL318721
7-(pentan-3-yl)-7h-pyrrolo[3,2-f]quinazoline-1,3-diamine
7-(pentan-3-yl)-7H-pyrrolo(3,2-f)quinazoline-1,3-diamine
7-(1-ETHYL-PROPYL)-7H-PYRROLO-(3,2-F)QUINAZOLINE-1,3-DIAMINE
GW3
SCHEMBL9568542
BDBM18043
DB07862
PD004943
NS00068159
3-Diethylmethylpyrrolo[3,2-f]quinazoline-7,9-diamine
Q27097073
7-(1-ethylpropyl)pyrrolo[3,2-f]quinazoline-1,3-diamine
7-(1-ethylpropyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
7-(1-ethylpropyl)7h-pyrrolo-[3,2-f]quinazoline-1,3-diamine
1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QUINAZOLINE
5-(pentan-3-yl)-5,10,12-triazatricyclo[7.4.0.0;{2,6}]trideca-1(13),2(6),3,7,9,11-hexaene-11,13-diamine