Testosterone acetate | Solubility of Things

Identification

Molecular formula

C₂₂H₃₀O₄

CAS number

1045-69-8

IUPAC name

[(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

State

At room temperature, testosterone acetate is in a solid state, specifically as a crystalline powder, often used in pharmaceutical formulations.

Melting point (Celsius)

139.00

Melting point (Kelvin)

412.15

Boiling point (Celsius)

362.90

Boiling point (Kelvin)

636.05

General information

Molecular weight

372.54g/mol

Molar mass

388.5750g/mol

Density

1.1000g/cm³

Appearence

Testosterone acetate appears as a crystalline powder that is white or off-white in color. It is noted for its distinct crystalline structure.

Comment on solubility

Solubility Characteristics

The compound (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl acetate with the chemical formula C₂₂H₃₀O₄ presents unique solubility behaviors that are important for various applications.

In general, the solubility of organic compounds can be influenced by several factors:

Polarity: The presence of hydroxyl groups or other polar functional groups can enhance solubility in polar solvents like water.
Molecular Size: Larger organic molecules often show reduced solubility due to steric hindrance and lower interactions with solvent molecules.
Hydrogen Bonding: Compounds capable of forming hydrogen bonds may exhibit increased solubility in appropriate solvents.

For this specific compound:

The presence of the acetate group suggests potential solubility in organic solvents such as ethanol or acetone.
However, its large hydrocarbon backbone may limit solubility in polar solvents like water.
As a guideline, *"like dissolves like,"* meaning that its solubility will be higher in nonpolar or slightly polar solvents.

Overall, while the compound may exhibit moderate solubility in organic solvents, its overall solubility profile is limited when interacting with highly polar solvents. Understanding these solubility dynamics is crucial for its practical use in chemical formulations.

Interesting facts

Interesting Facts about 17-Acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl Acetate

This compound, known for its unique structural composition, is a fascinating example of a derivative of natural products, often linked with steroid hormones. Here are some engaging aspects of this compound:

Steroidal Influences: Its structure suggests close relations to steroid frameworks, which play a critical role in several physiological processes including metabolism, immune response, and reproductive functions.
Applications in Medicine: Compounds of this type are frequently researched in pharmacology, particularly for their potential use as anti-inflammatory agents or in hormone replacement therapies.
Synthetic Pathways: The synthesis of such complex molecules exemplifies the intricacies of organic chemistry, requiring a mastery of multi-step reactions and an understanding of stereochemistry.
Chiral Centers: This compound features multiple chiral centers, making its stereochemical configuration crucial for its biological activity. The arrangement of atoms in three-dimensional space can drastically influence potency and efficacy.
Natural Sources: Many compounds with similar structures are derived from plant sources, indicating a rich tradition of botanical chemistry and its applications.

As a chemistry student or enthusiast, exploring compounds like this not only sharpens your understanding of organic chemistry but also highlights the interconnectedness of chemistry with biological systems. As noted by many researchers, “Exploring the relationships between structure and activity is the heart of medicinal chemistry.” This compound encapsulates that essence beautifully.

Synonyms

Medroxyprogesterone acetate

71-58-9

Medroxyprogesterone 17-acetate

Provera

Depo-Provera

Metigestrona

Gestapuran

Perlutex

Veramix

Methylacetoxyprogesterone

Medroxyacetate progesterone

Depcorlutin

Supprestral

Clinovir

Deporone

Farlutin

Oragest

Prodasone

Amen

Depo-Promone

Promone-E

Medrosterona

Indivina

Lutopolar

Mepastat

Nadigest

Progestalfa

Progevera

Proverone

Ralovera

Repromix

Sirprogen

Sumiferm

Suprestral

Veraplex

Cykrina

Depocon

Meprate

Nidaxin

Dugen

Depo-Prodasone

Depo-Ralovera

Perlutex Leo

Depot-medroxyprogesterone acetate

Depo-Map

Med-Pro

Aragest 5

MPA-beta

6-alpha-Methyl-17-alpha-acetoxyprogesterone

Cycrin

MPA Hexal

MPA-Noury

Depo-Subq Provera 104

NSC-26386

6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate

Farlutal

MPA GYM

Medroxyprogesteroneacetate

17alpha-Hydroxy-6alpha-methylprogesterone acetate

6alpha-Methyl-17alpha-hydroxyprogesterone acetate

Depo-subq provera

Depo-Medroxyprogesterone acetate

DP150

6alpha-Methyl-4-pregnene-3,20-dion-17alpha-ol acetate

CCRIS 371

17-Acetoxy-6alpha-methylprogesterone

6alpha-Methyl-17-acetoxy progesterone

Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6alpha)-

Depot medroxyprogesterone acetate

Medroxyprogesterone acetate [JAN]

C2QI4IOI2G

Depo-Provera Contraceptive

EINECS 200-757-9

NSC 21171

NSC-21171

Aragest

Hysron

Provera (TN)

Depomedroxyprogesterone acetate

Provera dosepak

Depo-clinovir

BRN 2066112

Depo-provera (TN)

Medroxyprogesterone 17 Acetate

CHEBI:6716

MLS001148217

DTXSID0025527

AI3-60127

(6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione

(6alpha)-6-methyl-3,20-dioxopregn-4-en-17-yl acetate

17-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione acetate

Medroxyprogesteroni acetas

U 8839

Medroxiprogesterone Acetate

Medroxyprogesterone acetate [USP:JAN]

17alpha-Hydroxy-6-alpha-methylprogesterone acetate

TV-46046

6alpha-Methyl-17alpha-acetoxypregn-4-ene-3,20-dione

17alpha-Acetoxy-6-alpha-methylpregn-4-ene-3,20-dione

MLS000069442

DTXCID905527

Depo-subq provera 104 (TN)

(6-alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione

6alpha-Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-

Medroxy Progesterone 17-Acetate

17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione acetate

ONCO-Provera

4-08-00-02212 (Beilstein Handbook Reference)

CBP-1011

NSC21171

NSC26386

Medroxyprogesterone acetate (Standard)

17alpha-Acetoxy-6alpha-methylprogesterone

Clinofem

MEDROXYPROGESTERONE ACETATE [IARC]

Repromap

SMR000059125

MEDROXYPROGESTERONE ACETATE [VANDF]

Pregn-4-ene-3,20-dione, 17-hydroxy-6alpha-methyl-, acetate

Depo-progestin

MEDROXYPROGESTERONE ACETATE [MART.]

Depo-Progevera

MEDROXYPROGESTERONE 17-ACETATE [MI]

MEDROXYPROGESTERONE ACETATE [USP-RS]

MEDROXYPROGESTERONE ACETATE [WHO-DD]

MEDROXYPROGESTERONE ACETATE [WHO-IP]

Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6.alpha.)-

MEDROXYPROGESTERONE ACETATE [ORANGE BOOK]

MEDROXYPROGESTERONE ACETATE [EP MONOGRAPH]

MEDROXYPROGESTERONI ACETAS [WHO-IP LATIN]

Metipregnone

LUNELLE COMPONENT MEDROXYPROGESTERONE ACETATE

MAP (steroid)

MEDROXYPROGESTERONE ACETATE [USP MONOGRAPH]

MEGESTROL ACETATE IMPURITY A [EP IMPURITY]

PREMPRO COMPONENT MEDROXYPROGESTERONE ACETATE

g-Farlutal

PREMPHASE COMPONENT MEDROXYPROGESTERONE ACETATE

Depo-mpa

Sodelut G

DepoProvera

Depo Provera

Medroxyprogesterone acetate (USP:JAN)

CAS-71-58-9

MEDROXYPROGESTERONE ACETATE (IARC)

MEDROXYPROGESTERONE ACETATE (MART.)

MEDROXYPROGESTERONE ACETATE (USP-RS)

17.alpha.-Acetoxy-6.alpha.-methylprogesterone

MEDROXYPROGESTERONE ACETATE (EP MONOGRAPH)

MEDROXYPROGESTERONE ACETATE (USP MONOGRAPH)

MEGESTROL ACETATE IMPURITY A (EP IMPURITY)

UNII-C2QI4IOI2G

6alpha-Methyl-17-acetoxyprogesterone

17-Acetoxy-6-alpha-methylprogesterone

(6.alpha.-Pregn-4-ene-3, 17-(acetyloxy)-6-methyl-

17.alpha.-Hydroxy-6-.alpha.-methylprogesterone acetate

Pregn-4-ene-3, 17-hydroxy-6.alpha.-methyl-, acetate

6-alpha-Methyl-17-acetoxy progesterone

Pregn-4-ene-3, 17-(acetyloxy)-6-methyl-, (6.alpha.)-

Ciclotal

Climanor

Sayana press

Depo Medroxyprogesterone Acetate

Nadigest (vet)

Nidaxin (vet)

17-Acetoxy-6.alpha.-methylprogesterone

6.alpha.-Methyl-17-acetoxyprogesterone

NCGC00094713-01

6-alpha-Methyl-17alpha-hydroxyprogesterone Acetate

Progesterone, 17-hydroxy-6alpha-methyl-, acetate

17-alpha-Hydroxy-6-alpha-methylprogesterone acetate

Farlutal 100

Farlutal 200

Farlutal 250

Farlutal 500

ANOESTRULILN

Depo-provera oncology

17-alpha-Acetoxy-6-alpha-methylpregn-4-ene-3,20-dione

6-alpha-Methyl-17-alpha-acetoxypregn-4-ene-3,20-dione

Progesterone, 17-alpha-hydroxy-6-alpha-methyl-, acetate

Medroxyprogesterone acetate [Progestins]

PROMONE E

6-alpha-Methyl-4-pregnene-3,20-dion-17-alpha-ol acetate

6.alpha.-Methyl-17.alpha.-acetoxyprogesterone

CPD000653524

17-alpha-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dione acetate

Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6a)-

Opera_ID_1110

medroxyprogesterone-acetate

17.alpha.-Hydroxy-6.alpha.-methylprogesterone acetate

6.alpha.-Methyl-17.alpha.-hydroxyprogesterone acetate

CHEMBL717

SCHEMBL4276

6.alpha.-Methyl-17.alpha.-acetoxypregn-4-ene-3,20-dione

Medroxyprogesterone (acetate)

[(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

17.alpha.-Acetoxy-6-.alpha.-methylpregn-4-ene-3,20-dione

6 alpha Methyl 17alpha hydroxyprogesterone Acetate

6.alpha.-Methyl-4-pregnene-3,20-dion-17.alpha.-ol acetate

MLS002207115

Medroxyprogesterone acetic acid

17.alpha.-Hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione acetate

HY-B0469R

(6 alpha)-17-(Acetoxy)-6-methylpregn-4-ene-3,20-dione

Depot-Medroxyprogestereone Acetate

HMS2233O07

HMS2235E05

HMS3259O14

HMS3884B10

(6-alpha)-Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-

(6S,8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

HY-B0469

Tox21_111319

Tox21_200141

BDBM50067678

s2567

AKOS015894870

Tox21_111319_1

AC-2174

CCG-264965

DB00603

FM25036

NC00574

Medroxyprogesterone acetate (JP18/USP)

MRF-0000023

NCGC00022037-03

NCGC00022037-04

NCGC00022037-05

NCGC00022037-07

NCGC00257695-01

NCGC00263480-01

AS-13981

SMR000653524

6-Alpha-methyl-17alpha-acetoxyprogesterone

CS-0694837

NS00006415

6-ALPHA-METHYL-17-ACETOXYPROGESTERONE

C08150

C76275

D00951

AB00384270-14

AB00384270_15

EN300-7480751

Medroxyprogesterone 17-acetate, >=97% (HPLC)

Medroxyprogesterone Acetate Injectable Suspension

17-ALPHA-ACETOXY-6-ALPHA-METHYLPROGESTERONE

6alpha-Methyl-3,20-dioxopregn-4-en-17-yl acetate

Q2823834

17-(Acetyloxy)-6alpha-methylpregn-4-ene-3,20-dione

6.alpha.-Pregn-4-ene-3, 17-(acetyloxy)-6-methyl-

MEDROXYPROGESTERONE ACETATE COMPONENT OF LUNELLE

MEDROXYPROGESTERONE ACETATE COMPONENT OF PREMPRO

MEDROXYPROGESTERONE ACETATE COMPONENT OF PREMPHASE

(6alpha)-17-(Acetyloxy)-6-methylpregn-4-ene-3,20-dione

17-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dione acetate

Medroxyprogesterone-17-acetate 100 microg/mL in Acetonitrile

(6-ALPHA)-17-(ACETYLOXY)-6-METHYLPREGN-4-ENE-3,20-DIONE

17-HYDROXY-6.ALPHA.-METHYLPREGN-4-ENE-3,20-DIONE ACETATE

Medroxyprogesterone 17-acetate, VETRANAL(TM), analytical standard

Medroxyprogesterone acetate, European Pharmacopoeia (EP) Reference Standard

PREGN-4-ENE-3,20-DIONE, 17-(ACETYLOXY)-6-METHYL-, (6-ALPHA)-

PREGN-4-ENE-3,20-DIONE, 17-HYDROXY-6-ALPHA-METHYL-, ACETATE

Pregn-4-ene-3,20-dione, 17-hydroxy-6alpha-methyl-, acetate (8CI)

Medroxyprogesterone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

Medroxyprogesterone acetate, United States Pharmacopeia (USP) Reference Standard

(1R,3aS,3bR,5S,9aR,9bS,11aS)-1-acetyl-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate

(6?)-17-(Acetyloxy)-6-methyl-pregn-4-ene-3,20-dione;17?-Acetoxy-6?-methylpregn-4-ene-3,20-dione;17?-Acetoxy-6?-methylprogesterone

200-757-9

Medroxyprogesterone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard

Medroxyprogesterone acetate for system suitability, European Pharmacopoeia (EP) Reference Standard