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Berberine hydrochloride

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Identification
Molecular formula
C20H18ClNO4
CAS number
633-65-8
IUPAC name
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride
State
State

At room temperature, berberine hydrochloride is typically found as a solid substance. It maintains its structural integrity as a crystalline powder under standard conditions.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
371.83g/mol
Molar mass
371.8300g/mol
Density
1.3800g/cm3
Appearence

Berberine hydrochloride appears as a yellow crystalline powder, often utilized for its aesthetic and chemical properties. This compound is known for its vibrant color, which is a deep yellow, and its crystalline nature.

Comment on solubility

Solubility of (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride

The solubility characteristics of the compound (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride can be quite intricate due to its structural complexity. Analyzing the solubility of this hydrochloride salt involves several factors:

  • Polarity: The presence of hydroxyl (-OH) groups often increases the polarity of a compound, enhancing its solubility in polar solvents, particularly water.
  • Salt formation: As a hydrochloride salt, this compound may exhibit higher solubility in aqueous solutions compared to its free base form due to greater ionization.
  • Functional groups: The overall molecular structure suggests that it contains both aromatic and non-aromatic regions, which can create a balance between solubility in organic solvents and water.
  • Temperature dependency: Solubility may increase with temperature, making it potentially more soluble when heated.

In summary, the solubility of (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride can be expected to be moderate to high in polar solvents like water, particularly at elevated temperatures, allowing it to engage in various chemical processes effectively.

Interesting facts

Interesting Facts About (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride

This intriguing compound belongs to the class of dibenzoquinolines, which are known for their complex structures and diverse biological activities. Here are some noteworthy points about this compound:

  • Pharmacological Potential: Many dibenzoquinoline derivatives are investigated for their potential use in medicine, especially in treating various neurological disorders and cancers.
  • Synthesis Challenges: The synthesis of such multi-ring systems poses significant challenges in organic chemistry, often requiring advanced techniques and careful manipulation of reaction conditions.
  • Stereochemistry Matters: The specific stereochemistry of this compound, particularly the (6aR) configuration, is crucial for its biological activity and properties. Understanding this can lead to insights into how similar compounds can be optimized for therapeutic use.
  • Analytical Techniques: Characterizing such a complex structure often involves advanced spectroscopic methods, including NMR and mass spectrometry, which provide detailed information about molecular configuration.
  • Historical Context: Dibenzoquinolines have intrigued chemists since the mid-20th century, and studying them has expanded our understanding of polycyclic compounds.

In summary, the study of (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride not only exemplifies the complexity of synthetic organic chemistry but also holds potential significance in pharmacological applications. The interplay between its structure, stereochemistry, and biological activity remains a rich field of study for both chemists and pharmacologists alike.

Synonyms
Apomorphine hydrochloride
314-19-2
Apomorphine HCl
Apomorphine chloride
(R)-(-)-Apomorphine hydrochloride
Apokyn
Apomorphinium chloride
Apomorphine SL
(-)-Apomorphine hydrochloride
Apomorphine hydrochloride anhydrous
Uprima
N-Methylnorapomorphine hydrochloride
Apomorphin hydrochlorid
pomorphini hydrochloridum
Apomorphinum hydrochloricum
(-)-Apomorphinium hydrochloride
9K13MD7A0D
Apomorphine.HCl
EINECS 206-243-0
NSC 11442
UNII-9K13MD7A0D
NSC-11442
6a-beta-Aporphine-10,11-diol, hydrochloride
41372-20-7
6abeta-Noraporphine-10,11-diol, 6-methyl-, hydrochloride
6a-beta-Noraporphine-10,11-diol, 6-methyl-, hydrochloride
6abeta-Aporphine-10,11-diol, hydrochloride
5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo(de,g)chinolin-10,11-diol hydrochlorid
Apokinon
Britaject
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)-
Anhydrous Apomorphine Hydrochloride
NSC11442
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (6aR)-
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (R)-
(R)-Apomorphine hydrochloride
apomorphine-hcl
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride
Prestwick_28
4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)-
(6AR)-5,6,6A,7-TETRAHYDRO-6-METHYL-4H-DIBENZO(DE,G)QUINOLINE-10,11-DIOL HYDROCHLORIDE
R-(-)-apomorphine HCl
SCHEMBL8524
(R)-(-)-apomorphine HCl
DTXSID5040598
Apomorphine hydrochloride (R,-)
APOMORPHINE, HYDROCHLORIDE
R-(-)-Apomorphine hydrochloride
APOMORPHINE HYDROCHLORIDE [MI]
6a.beta.-Aporphine-10, hydrochloride
AKOS024456928
FA31759
SR-01000597777
Apomorphine.HCl, 1mg/ml in Methanol (as free base)
SR-01000597777-1
6A.BETA.-APORPHINE-10,11-DIOL HYDROCHLORIDE
6a.beta.-Noraporphine-10, 6-methyl-, hydrochloride
Q27272658
WLN: T C6666 1A Q KN & TT & J DQ EQ K1 & GH
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride
4H-Dibenzo[de,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (R)-
(6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride;6a-b-Aporphine-10,11-diol hydrochloride;(-)-10