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6,7-dimethoxy-N-phenylquinazolin-4-amine

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Identification
Molecular formula
C16H15N3O2
CAS number
75719-39-4
IUPAC name
6,7-dimethoxy-N-phenyl-quinazolin-4-amine
State
State

This compound is typically in a solid state at room temperature. Due to its crystalline nature, it is commonly found in powder or small chunk form.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
498.35
Boiling point (Kelvin)
771.50
General information
Molecular weight
281.32g/mol
Molar mass
281.3190g/mol
Density
1.2620g/cm3
Appearence

This compound appears as a solid crystalline substance which can vary in color from white to light gray or pale yellow, depending on purity and handling conditions. It is usually odorless, but specific impurities could affect its appearance and smell.

Comment on solubility

Solubility of 6,7-dimethoxy-N-phenyl-quinazolin-4-amine

The solubility of 6,7-dimethoxy-N-phenyl-quinazolin-4-amine (C16H15N3O2) is an important aspect to consider for its application in pharmaceuticals and chemical research. While specific solubility data may vary based on factors such as temperature and solvent choice, there are some general expectations based on its structure:

  • Polar vs. Non-polar Solvents: The presence of methoxy groups and an amine functional group suggests that this compound may exhibit moderate solubility in polar solvents, such as water and alcohol.
  • Temperature Dependence: Solubility can significantly increase with temperature, particularly in organic solvents, allowing for better dissolution.
  • Hydrogen Bonding: The ability of the amine group to form hydrogen bonds could enhance solubility in polar environments, facilitating interaction with other molecules and solvents.
  • Crystallinity: The crystal structure and morphology of the compound could also impact its solubility, with more crystalline forms typically being less soluble.

In summary, while more precise solubility values would require experimental determination, it’s reasonable to suggest that 6,7-dimethoxy-N-phenyl-quinazolin-4-amine shows promising solubility characteristics, particularly in polar solvents. The interplay of functional groups in its structure plays a crucial role in determining its overall solubility profile.

Interesting facts

6,7-Dimethoxy-N-phenyl-quinazolin-4-amine: A Fascinating Compound

6,7-Dimethoxy-N-phenyl-quinazolin-4-amine is a remarkable compound that belongs to the quinazoline family, a group of heterocyclic compounds known for their diverse biological activities. This compound is particularly interesting due to its unique structure, which includes:

  • Two methoxy groups that enhance its solubility and influence its chemical reactivity.
  • A phenyl group that adds to its aromatic character, making it a potential candidate for various pharmacological applications.
  • A quinazolin-4-amine core, which is known for its role in numerous medicinal chemistry pursuits.

Many scientists are drawn to quinazoline derivatives due to their promising therapeutic potential. Research has shown that compounds similar to 6,7-dimethoxy-N-phenyl-quinazolin-4-amine may exhibit:

  • Anticancer properties, particularly in targeting specific cancer cell lines.
  • Antimicrobial activity that could provide new avenues for treating bacterial infections.
  • Anti-inflammatory effects that may be beneficial in managing chronic inflammatory conditions.

One of the exciting aspects of studying this compound is the potential for structure-activity relationship (SAR) explorations, where small modifications to its structure can lead to vastly different biological activities. As researchers continue to investigate its properties, it could pave the way for the development of new therapeutic agents.

In conclusion, 6,7-dimethoxy-N-phenyl-quinazolin-4-amine serves as a prime example of how small changes in a chemical structure can lead to profound effects in biological activity and medicinal chemistry. It's a compound that invites further exploration and a deeper understanding of its potential applications in science and medicine.

Synonyms
21561-09-1
WHI-P258
6,7-dimethoxy-N-phenylquinazolin-4-amine
4-Phenylamino-6,7-dimethoxyquinazoline
4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-
6,7-dimethoxy-N-phenyl-4-quinazolinamine
CHEMBL94191
MFCD01815294
Oprea1_506594
BDBM3530
SCHEMBL1257431
WHI-P 258
WHI-P258?
DTXSID80274409
HMS1662N04
BCP15149
EX-A1237
s6521
AKOS002350879
AC-38050
DA-68697
HY-108419
4-(phenyl)-amino-6,7-dimethoxy-quinazoline
CS-0028609
11N-058
SR-02000000179
SR-02000000179-1