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6-Nitro-2-(piperazin-1-yl)quinoline

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Identification
Molecular formula
C13H14N4O2
CAS number
78024-04-1
IUPAC name
6-nitro-2-piperazin-1-yl-quinoline
State
State
At room temperature, 6-Nitro-2-(piperazin-1-yl)quinoline is a solid. It does not easily vaporize and remains stable in its crystalline form under normal atmospheric conditions.
Melting point (Celsius)
209.00
Melting point (Kelvin)
482.15
Boiling point (Celsius)
496.70
Boiling point (Kelvin)
769.90
General information
Molecular weight
272.29g/mol
Molar mass
272.2950g/mol
Density
1.2904g/cm3
Appearence

6-Nitro-2-(piperazin-1-yl)quinoline typically presents as a yellow crystalline powder or solid. The intensity of the yellow color can vary depending on the purity and specific form it appears in. The crystalline structure may be well-defined under a microscope.

Comment on solubility

Solubility of 6-nitro-2-piperazin-1-yl-quinoline

6-nitro-2-piperazin-1-yl-quinoline (C13H14N4O2) exhibits a notable range of solubility characteristics that are determined by its molecular structure and functional groups. Here are some key points regarding its solubility:

  • Solvent Dependence: The solubility of this compound varies significantly depending on the solvent used. It tends to be more soluble in polar solvents such as methanol and dimethyl sulfoxide (DMSO), which can stabilize the polar functional groups.
  • Water Solubility: Its solubility in water is limited and considered low, primarily due to the presence of aromatic rings that contribute to hydrophobic interactions.
  • Effect of Temperature: As with many organic compounds, an increase in temperature can enhance solubility, making it more favorable in higher-temperature conditions.
  • pH Sensitivity: The solubility can be affected by pH variations. For instance, in acidic conditions, protonation of the piperazine group may enhance solubility due to the increased hydrophilicity.

In summary, the solubility of 6-nitro-2-piperazin-1-yl-quinoline is multifaceted and influenced by various environmental factors. Understanding these properties is essential for its practical applications in pharmaceutical and chemical research. Always keep in mind the importance of considering solvent choice and conditions when assessing solubility, as highlighted by the phrase, "Solubility is the key to potential!"

Interesting facts

6-Nitro-2-piperazin-1-yl-quinoline

6-Nitro-2-piperazin-1-yl-quinoline is a fascinating compound that has captured the attention of researchers due to its potential applications in medicinal chemistry. Here are some interesting facts about this unique molecule:

  • Pharmacological Potential: This compound has been investigated for its antimicrobial and antiparasitic properties, making it a candidate for treating various infectious diseases.
  • Chemical Structure: The presence of both a quinoline and a piperazine ring in its structure contributes to the compound's unique chemical reactivity and biological activity.
  • Nitro Group Influence: The nitro group (-NO2) present at the 6-position of the quinoline ring is known to enhance the compound's lipophilicity, aiding its ability to penetrate cell membranes and improve bioavailability.
  • Research Applications: Beyond its potential therapeutic uses, this compound is also studied in the fields of material science and fluorescent labeling due to its interesting photophysical properties.
  • Structural Analogues: The design of analogues of 6-nitro-2-piperazin-1-yl-quinoline can lead to the development of even more potent drugs by modifying functional groups or altering the ring structures, allowing scientists to explore a wide spectrum of biological activity.

In summary, 6-nitro-2-piperazin-1-yl-quinoline serves as an exemplary molecule that bridges the fields of chemistry and biology. Its unique structure prompts ongoing research, aimed at uncovering new therapeutic leads.

Synonyms
6-nitroquipazine
77372-73-7
6-Nitro-2-piperazin-1-yl-quinoline
6-nitro-2-(piperazin-1-yl)quinoline
DU-24565
6-nitro-2-piperazin-1-ylquinoline
6-Nitro,2-(1-piperazinyl)quinoline
DU 24565
UNII-28M0X094BH
Quinoline, 6-nitro-2-(1-piperazinyl)-
CHEMBL41140
DTXSID7044001
28M0X094BH
6-Nitro-2-(1-piperazinyl)quinoline maleate salt
C13H14N4O2
MFCD04115271
Lopac-Q-109
Biomol-NT_000101
Lopac0_001010
SCHEMBL401156
BPBio1_001389
DTXCID5024001
CHEBI:104164
GGDBEAVVGFNWIA-UHFFFAOYSA-N
6-nitro-2-(1-piperazinyl)quinoline
BDBM50063266
MFCD00153868
AKOS009510172
AB19843
CCG-205090
SDCCGSBI-0050983.P002
NCGC00015868-01
NCGC00015868-02
NCGC00015868-03
NCGC00015868-04
NCGC00015868-06
NCGC00162315-01
NCGC00162315-02
PD092963
DB-075299
CS-0136860
Q4641548
BRD-K95821857-001-01-2