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6-Nitrobenzimidazole

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Identification
Molecular formula
C7H5N3O2
CAS number
6973-78-0
IUPAC name
6-nitro-1H-benzimidazole
State
State

Solid at room temperature.

Melting point (Celsius)
283.00
Melting point (Kelvin)
556.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
177.15g/mol
Molar mass
177.1530g/mol
Density
1.4600g/cm3
Appearence

6-Nitrobenzimidazole is typically observed as an orange to yellow crystalline powder. It may have a hint of redness depending on purity and particle size.

Comment on solubility

Solubility of 6-nitro-1H-benzimidazole

6-nitro-1H-benzimidazole is an intriguing compound when it comes to its solubility characteristics. Understanding the solubility of this compound can be essential for various applications in both industry and research. Here are some key points regarding its solubility:

  • Solvent Dependence: The solubility of 6-nitro-1H-benzimidazole can vary significantly depending on the solvent used. It is more soluble in polar solvents compared to non-polar solvents.
  • Hydrogen Bonding: The presence of nitrogen atoms in the structure allows for potential hydrogen bonding, which can dramatically affect its solubility in polar solvents like water or alcohols.
  • Temperature Effects: Like many chemical compounds, the solubility of 6-nitro-1H-benzimidazole may increase with temperature, making it important to consider in practical applications.
  • Applications: Its solubility attributes are particularly valuable in organic synthesis and pharmaceutical formulations, where precise solubility characteristics can influence drug delivery efficiency.

In summary, while 6-nitro-1H-benzimidazole exhibits interesting solubility traits, it remains essential to consider factors such as solvent type, temperature, and application requirements when examining its behavior in various environments.

Interesting facts

Exploring 6-Nitro-1H-benzimidazole

6-Nitro-1H-benzimidazole is a fascinating compound known for its unique structure and diverse applications in the fields of chemistry and medicinal science. Here are some intriguing facts about this compound:

  • Chemical Structure: The compound features a benzimidazole ring system that is modified with a nitro group at the 6-position. This structural uniqueness contributes significantly to its chemical reactivity.
  • Biological Significance: 6-Nitro-1H-benzimidazole and its derivatives have been investigated for their potential as pharmaceutical agents. They display various biological activities, including antimicrobial and antitumor properties.
  • Role in Research: This compound has been employed in numerous research studies to explore enzyme inhibition and pharmacological activity, particularly in drug discovery processes revolving around cancer therapeutics.
  • Reactivity: The nitro group is known for enhancing the compound's reactivity, making it suitable for various synthetic chemical reactions, which can lead to the development of novel compounds with varied functionalities.

As noted by researchers in the field, "the modifications made to the benzimidazole framework can significantly alter the biological activity of the compound, paving the way for advancements in medicinal chemistry." The versatility of 6-nitro-1H-benzimidazole truly exemplifies the potential of small organic molecules in addressing critical challenges in health and disease.

In summary, 6-nitro-1H-benzimidazole is not only structurally interesting but also vital for ongoing scientific explorations in pharmacology and organic synthesis. Its role in drug design continues to inspire new avenues for research and application in medicinal chemistry.

Synonyms
5-NITROBENZIMIDAZOLE
94-52-0
6-Nitrobenzimidazole
5-Nitro-1H-benzimidazole
5-nitro-1H-benzo[d]imidazole
1H-Benzimidazole, 5-nitro-
1H-Benzimidazole, 6-nitro-
6-Nitro-1H-benzimidazole
5-nitro-1H-1,3-benzodiazole
5(6)-Nitrobenzimidazole
6-Nitro-benzimidazole
Benzimidazole, 5-nitro-
Benzimidazole, 6-nitro-
NCI-C01912
CCRIS 442
HSDB 2864
5-Nitro-1H-benzoimidazole
NSC 3068
EINECS 202-341-2
A7V95AYT2T
MFCD00005604
NSC 58858
6-nitro-1H-1,3-benzodiazole
DTXSID8020965
AI3-52609
Benzimidazole, 5(or 6)-nitro-
NSC-3068
NSC-58858
DTXCID60965
MLS002637666
CHEMBL164921
5-NITROBENZIMIDAZOLE [HSDB]
benzimidazole, 5(6)-nitro-
WLN: T56 BM DNJ HNW
CAS-94-52-0
UNII-A7V95AYT2T
4msa
6Nitrobenzimidazole
2ZM
5-nitrobenzoimidazol
5-Nitrobenzimidizole
6-Nitrobenzimidizole
5-nitrobenzoimidazole
5Nitro1Hbenzimidazole
5-nitro-benzimidazole
Benzimidazole, 5nitro
Benzimidazole, 6nitro
4n9c
5(6)Nitrobenzimidazole
1HBenzimidazole, 5nitro
1HBenzimidazole, 6nitro
5(6)-nitro-benzimidazole
6-Nitro-1H-benzoimidazole
Oprea1_525754
Oprea1_664147
SCHEMBL271340
Benzimidazole, 5-nitro-(8CI)
MSK5513
NSC3068
HMS3079A05
ALBB-036670
BCP26862
NSC58858
Tox21_201684
Tox21_302828
BDBM50208881
MFCD00040457
STK299272
AKOS000275609
AKOS003790796
AKOS015970456
CS-W010848
FN71154
HY-W010132
s10799
NCGC00091868-01
NCGC00091868-02
NCGC00091868-03
NCGC00091868-04
NCGC00091868-05
NCGC00091868-06
NCGC00256398-01
NCGC00259233-01
AC-11286
AS-46775
SMR001305771
SY003312
DB-057506
Benzimidazole, 5(or 6)-nitro-(6CI,7CI)
EU-0067493
N0152
NS00020041
EN300-34514
AE-641/30196001
AH-357/03464041
SR-01000394488
SR-01000394488-1
Q27273738
F0020-1984
InChI=1/C7H5N3O2/c11-10(12)5-1-2-6-7(3-5)9-4-8-6/h1-4H,(H,8,9
202-341-2