Skip to main content

Papaverine

ADVERTISEMENT
Identification
Molecular formula
C20H21NO4
CAS number
58-74-2
IUPAC name
6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
State
State

At room temperature, papaverine is in a solid state. It exists as a crystalline powder and is stable under standard temperature and pressure conditions. It is known for its moderate solubility in water but is more soluble in organic solvents such as ethanol and chloroform.

Melting point (Celsius)
147.50
Melting point (Kelvin)
420.65
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
339.37g/mol
Molar mass
339.3700g/mol
Density
1.3600g/cm3
Appearence

Papaverine is a white to off-white crystalline powder. It is generally odorless but may have a slight odor. Its crystalline structure is an indication of purity and proper crystallization. This compound can form needles or plates when crystallized from solvents such as alcohol or ether.

Comment on solubility

Solubility of 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol (C20H21NO4)

The solubility of 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol in various solvents can significantly affect its applications in both research and industry. Understanding its solubility behavior is crucial for effective utilization.

Key Points on Solubility:

  • Solvent Compatibility: This compound is likely to exhibit variable solubility in different solvents. Polar solvents such as water and alcohols may dissolve it to a certain extent, while non-polar solvents could show limited solubility.
  • pH Sensitivity: The solubility may also depend on the pH of the solvent, given the presence of hydroxyl (–OH) groups that can engage in hydrogen bonding.
  • Temperature Influence: Generally, an increase in temperature tends to enhance solubility for many organic compounds; hence, testing at elevated temperatures might reveal a greater solubility profile.

In summary, it is essential to perform detailed solubility studies to ascertain the specific conditions under which 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol exhibits optimal solubility. This can help in tailoring processes for extraction, formulation, and application of this intriguing compound.

Interesting facts

Interesting Facts about 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol

The compound 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol, often referred to as a complex alkaloid, exhibits fascinating properties and structural intricacies. Here are some noteworthy aspects of this compound:

  • Structural Diversity: This compound belongs to the isoquinoline family, which is known for its diverse range of biological activities and pharmacological properties. The presence of a dioxolo moiety enhances its structural complexity.
  • Biological Significance: Compounds of this type have been studied for their potential therapeutic effects, including anti-inflammatory and neuroprotective activities. Research into alkaloids often uncovers novel mechanisms that can lead to new drug discoveries.
  • Synthetic Pathways: The synthesis of isoquinoline derivatives poses interesting challenges for chemists. Understanding the synthetic routes can lead to breakthroughs in organic synthesis techniques and improve the efficiency of creating other complex molecules.
  • Natural Sources: Many isoquinoline derivatives, including related compounds, are found in various plants, providing a rich source for natural product chemistry. Their isolation and characterization can reveal insights into plant defense mechanisms.
  • Cultural References: Alkaloids like this one have permeated various aspects of culture and history, often being associated with traditional medicine practices across different civilizations.

In conclusion, 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol is more than just a chemical compound; it represents the intricate tapestry of chemistry, biology, and cultural history. Each study of such compounds opens a door to new questions and discoveries, making the field of chemistry as dynamic as it is essential.

Synonyms
hydrastinine
6592-85-4
Hydraztinine
6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
V1I0L48X6E
1,3-Dioxolo[4,5-g]isoquinolin-5-ol, 5,6,7,8-tetrahydro-6-methyl-
5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-ol
5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol
NSC-755892
1,3-DIOXOLO(4,5-g)ISOQUINOLIN-5-OL, 5,6,7,8-TETRAHYDRO-6-METHYL-
EINECS 229-533-9
BRN 0014208
UNII-V1I0L48X6E
Hydrastinin
Spectrum_000377
Prestwick0_000195
Prestwick1_000195
Prestwick2_000195
Spectrum2_000742
Spectrum3_001149
Spectrum4_001762
Spectrum5_000343
HYDRASTININE [MI]
NCIOpen2_005877
Oprea1_843481
BSPBio_002677
KBioGR_002243
KBioSS_000857
4-27-00-06396 (Beilstein Handbook Reference)
DivK1c_000897
HYDRASTININE [WHO-DD]
SCHEMBL308521
SPBio_000724
SPBio_002070
CHEMBL1623232
DTXSID3048073
HY-B1181A
KBio1_000897
KBio2_000857
KBio2_003425
KBio2_005993
KBio3_002177
YOJQZPVUNUQTDF-UHFFFAOYSA-
NINDS_000897
1,3-Dioxolo(4,5-g)isoquinolin-5-ol, 5,6,7,8-tetrahyro-6-methyl-
1-hydroxy-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
AKOS040758263
NSC 755892
IDI1_000897
NCGC00178535-02
DA-64312
MS-23130
SBI-0051895.P003
SBI-0051895.P004
1ST181209
CS-0108783
NS00005375
1,3-DIOXOLO(4,5-G)ISOQUINOLIN-5-OL
F82493
AB00053699_03
AB00053699_04
Q905844
BRD-A57900429-003-05-8
BRD-A57900429-003-06-6
6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol #
InChI=1/C11H13NO3/c1-12-3-2-7-4-9-10(15-6-14-9)5-8(7)11(12)13/h4-5,11,13H,2-3,6H2,1H3