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A-366

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Identification
Molecular formula
C12H9N3O
CAS number
1602734-58-4
IUPAC name
6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile
State
State

At room temperature, A-366 is in a solid state. It is known to form a stable crystalline powder that remains solid under normal laboratory conditions, making it suitable for various experimental applications.

Melting point (Celsius)
257.00
Melting point (Kelvin)
530.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
237.25g/mol
Molar mass
237.2470g/mol
Density
1.2700g/cm3
Appearence

A-366 appears as a crystalline solid that typically ranges in color from white to off-white or pale yellow. It has a solid and particulate form, indicative of its crystalline nature, and it is usually provided as a powder for laboratory use.

Comment on solubility

Solubility of 6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile

The solubility of 6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile (C12H9N3O) exhibits some unique characteristics due to its chemical structure. Here are several key points to consider:

  • Polarity: The presence of a carbonitrile group (–C≡N) and a carbonyl function (–C=O) often contributes to increased polarity, which can enhance solubility in polar solvents.
  • Solvent Dependence: This compound is likely soluble in polar organic solvents such as dichloromethane, dMSO, and ethanol, but may have limited solubility in nonpolar solvents like hexane.
  • Hydrogen Bonding: Its structure allows for potential hydrogen bonding interactions, thus improving solubility in solvents capable of donating or accepting hydrogen bonds.
  • pH Influence: If the compound is ionizable, the solubility may also vary with pH levels, which can be important in various chemical and biological contexts.

In conclusion, the solubility of 6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile is dictated by its polar functional groups and structural properties, presenting interesting implications for its use in pharmaceutical applications where solubility is crucial.

Interesting facts

Exploring 6-Methyl-2-Oxo-5-(4-Pyridyl)-1H-Pyridine-3-Carbonitrile

The compound known as 6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile is a fascinating example of a heterocyclic organic compound, notable for its intriguing structure and potential applications. Here are some key points about this interesting compound:

  • Heterocyclic Nature: This compound contains a pyridine ring, which is a six-membered aromatic ring featuring one nitrogen atom. Pyridine derivatives are essential in medicinal chemistry.
  • Biological Activity: Many compounds with similar structures have shown promising pharmacological properties, including antimicrobial and anti-inflammatory effects, making this compound a subject of interest for further exploration.
  • Structural Features: The presence of a carbonitrile group and a ketone functionality in its structure suggests it could serve as a valuable intermediate in organic synthesis.
  • Potential Uses: Heterocyclic compounds like this are often studied for their roles in the design of new drugs or agricultural chemicals, as they can modulate biological activities.
  • Research Opportunities: Given its complex structure, this compound may serve as a model for studies in molecular interactions, paving the way for innovations in drug discovery.

In the words of a renowned chemist, "The beauty of chemistry lies in its ability to create molecules that can change lives." This compound exemplifies that beauty, revealing a world of possibilities for scientific investigation and product development.

Overall, the exploration of 6-methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carbonitrile could lead to many exciting advancements in the field of chemistry!

Synonyms
milrinone
78415-72-2
Primacor
Milrinona
Milrinonum
Milrila
Milrinonum [Latin]
Win-47203-2
6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile
1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
MFCD00133539
YM 018
CCRIS 3795
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
UNII-JU9YAX04C7
2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile
EINECS 278-903-6
JU9YAX04C7
WIN 47203
NSC-760072
BRN 3546821
1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
DTXSID5023324
WIN 47,203-2
CHEBI:50693
Corotrope
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
CHEMBL189
(3,4'-BIPYRIDINE)-5-CARBONITRILE, 1,6-DIHYDRO-2-METHYL-6-OXO-
DTXCID103324
(3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-
Milrinone [USAN:USP:INN:BAN]
Milrinonum (Latin)
NSC 760072
NCGC00015675-08
NCGC00164390-01
Milrinona [Spanish]
[3,4'-Bipyridine]-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo-
CAS-78415-72-2
MILRINONE (MART.)
MILRINONE [MART.]
MILRINONE (USP-RS)
MILRINONE [USP-RS]
2-hydroxy-6-methyl-5-pyridin-4-ylpyridine-3-carbonitrile
MILRINONE (USP MONOGRAPH)
MILRINONE [USP MONOGRAPH]
Milrinone (USAN:USP:INN:BAN)
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
SMR000058475
Milrila (TN)
WIN 47203-2
SR-01000075524
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
Milrinone?
1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile;Corotrope;Milrila
Milrinone(Primacor)
6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
Milrinone (Primacor)
Milrinone (Standard)
Tocris-1504
111GE027
MILRINONE [INN]
MILRINONE [JAN]
MILRINONE [MI]
MILRINONE [USAN]
1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)NICOTINONITRILE
Prestwick0_001065
Prestwick1_001065
Prestwick2_001065
Prestwick3_001065
Lopac-M-4659
MILRINONE [VANDF]
M1663
2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile (Milrinone)
M 4659
MILRINONE [WHO-DD]
Milrinone (JAN/USP/INN)
Lopac0_000737
SCHEMBL36947
BSPBio_001050
MLS000028818
MLS001424052
MLS006011946
BIDD:GT0197
Milrinone - Bio-X trade mark
SPBio_002965
BPBio1_001156
GTPL5225
SCHEMBL8309385
BDBM15296
C01CE02
HMS1571E12
HMS2051L10
HMS2090J14
HMS2098E12
HMS2234A23
HMS3262C16
HMS3267P12
HMS3370H18
HMS3393L10
HMS3656G06
HMS3715E12
HMS3742G09
Pharmakon1600-01505489
BCP02956
Tox21_112113
Tox21_400069
Tox21_500737
HY-14252R
Milrinone, >=97% (TLC), powder
NSC760072
s2484
Milrinone - CAS 78415-72-2
AKOS015836135
Tox21_112113_1
AC-4730
BCP9000926
CCG-101020
CCG-204822
CS-1367
DB00235
FM26007
KS-1440
LP00737
NC00270
SDCCGSBI-0050715.P002
NCGC00015675-01
NCGC00015675-02
NCGC00015675-03
NCGC00015675-04
NCGC00015675-05
NCGC00015675-06
NCGC00015675-07
NCGC00015675-09
NCGC00015675-11
NCGC00015675-24
NCGC00025189-01
NCGC00025189-02
NCGC00025189-03
NCGC00261422-01
BM164671
HY-14252
SMR004703527
SY028050
BCP0726000256
AB00514027
EU-0100737
NS00007740
SW197308-3
C07224
D00417
EN300-117244
AB00514027-02
AB00514027-03
AB00514027_04
AB00514027_05
AB00597139-08
A839417
Q847399
SR-01000075524-1
SR-01000075524-3
SR-01000075524-4
SR-01000075524-6
BRD-K67080878-001-05-5
BRD-K67080878-001-15-4
BRD-K67080878-001-16-2
Z1501480412
1,2-dihydro-6-methyl-2-oxo-5-(4 -pyridinyl)nicotinonitrile
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Milrinone, United States Pharmacopeia (USP) Reference Standard
1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)-NICOTINONITRILE
6-methyl-2-oxidanylidene-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
1,6-Dihydro-2-methyl-6-oxo-(3,4 inverted exclamation mark -bipyridine)-5-carbonitrile
278-903-6