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Thiafurin

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Identification
Molecular formula
C10H11NO4S2
CAS number
22410-44-2
IUPAC name
6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide
State
State

At room temperature, Thiafurin is typically found in a solid state. It is handled as a solid under standard laboratory conditions and stored in a dry environment to prevent any degradation or reaction with atmospheric moisture or other components.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
271.35g/mol
Molar mass
271.3460g/mol
Density
1.5000g/cm3
Appearence

Thiafurin typically appears as a white to off-white powder. Its appearance is crystalline and can be further described depending on the specific grade or purity level used in laboratory or industrial settings.

Comment on solubility

Solubility of 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide

The solubility of 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide (C10H11NO4S2) can be influenced by several factors due to its unique structural characteristics. Here's what you need to know:

  • Polarity: The presence of sulfonamide and carbonyl groups in the molecule contributes to its polarity, suggesting that the compound may be soluble in polar solvents.
  • Hydrogen Bonding: The chance to form hydrogen bonds due to functional groups can enhance solubility in water and other polar solvents.
  • Solvent Compatibility: A good solvent choice for this compound may be dimethyl sulfoxide (DMSO) or dimethylformamide (DMF), known for their ability to dissolve organic compounds with similar structures.

However, it's important to note that the solubility may vary significantly with changes in temperature and pH. For optimal solubility assessment, empirical methods should be employed. As a rule of thumb, like dissolves like; hence, its solubility profile aligns more with non-polar solvents despite its functional characteristics.

In practice, the determination of solubility often requires experimental validation. Thus, when working with this compound, consult relevant solubility data to ensure effective formulation.

Interesting facts

Interesting Facts about 6-Methyl-1,1-Dioxo-3,4-Dihydro-2H-Thiochromene-7-Sulfonamide

The compound 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide is a fascinating example of a thiochromene derivative, which showcases the diversity of chemical structures and their respective functionalities. This complex organic compound is notable for its unique structure, which includes:

  • Thiochromene core: This core structure contributes to the compound's reactivity and potential applications in medicinal chemistry.
  • Methyl group: The presence of the methyl group at position 6 may enhance its lipophilicity, altering its bioactive profile.
  • Dioxo and sulfonamide functionalities: These functional groups are often associated with biological activity, making this compound a candidate for pharmaceutical development.

Biological Significance

The incorporation of a sulfonamide group not only increases the potential for interactions with biological targets but may also lead to important medicinal properties. Sulfonamides have historically been used as:

  • Antimicrobial agents
  • Diuretics
  • Anti-inflammatory compounds

As a result, derivatives such as this one are of particular interest in drug discovery and development efforts aimed at treating various diseases.

Research Potential

Scientists continue to explore compounds like 6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide for their potential:

  • To serve as lead compounds in the search for novel therapeutics.
  • To provide insights into structure-activity relationships (SAR) in medicinal chemistry.
  • To contribute to the design of inhibitors or modulators affecting specific biological pathways.

In summary, the unique arrangement of atoms in this compound presents a rich opportunity for both academic and pharmaceutical research, underscoring the importance of thiochromene derivatives in the broader field of organic chemistry.

Synonyms
meticrane
1084-65-7
Arresten
Fontiliz
Meticrano
Meticranum [INN-Latin]
6-Methylthiochroman-7-sulfonamide 1,1-dioxide
Meticranum
Meticrano [INN-Spanish]
SD 17102
Meticrane [INN:DCF:JAN]
6-methyl-1,1-dioxo-3,4-dihydro-2H-thiochromene-7-sulfonamide
EINECS 214-112-4
Arresten (TN)
NSC-759309
E-103-E
I7EKN1924Q
DTXSID9045346
2H-1-Benzothiopyran-7-sulfonamide, 3,4-dihydro-6-methyl-, 1,1-dioxide
METICRANE [INN]
METICRANE [JAN]
METICRANE [MI]
6-Methyl-7-sulfamido-thiochroman-1,1-dioxide
METICRANE [MART.]
METICRANE [WHO-DD]
Thiochroman-7-sulfonamide, 6-methyl-, 1,1-dioxide
SD-17102
DTXCID7025346
6-methylthiochromane-7-sulfonamide 1,1-dioxide
6-Methyl-3,4-dihydro-2H-1-benzothiopyran-7-sulfonamide 1,1-dioxide
NSC 759309
NCGC00016561-01
CAS-1084-65-7
Meticranum (INN-Latin)
Meticrano (INN-Spanish)
METICRANE (MART.)
2H-1-Benzothiopyran-7-sulfonamide, 3,4-dihydro-6-methyl-, 1,1-dioxide (9CI)
6-Methylthiochroman-7-sulphonamide 1,1-dioxide;6-Methylthiochroman-7-sulfonamide 1,1-dioxide
SR-01000838874
UNII-I7EKN1924Q
Prestwick_881
MFCD00079454
Meticrane (Standard)
Prestwick0_000011
Prestwick1_000011
Prestwick2_000011
Prestwick3_000011
Meticrane (JP18/INN)
SCHEMBL49070
BSPBio_000041
MLS002154170
Meticrane, analytical standard
SPBio_001962
BPBio1_000047
CHEMBL1318341
CHEBI:31839
HY-B0908R
C03BA09
HMS1568C03
HMS2095C03
HMS2235D06
HMS3371D22
HMS3712C03
Pharmakon1600-01506077
HY-B0908
Tox21 110495
Tox21_110495
NSC759309
s4339
6-Methyl-1-thia-1,2,3,4-tetrahydronaphthalene-7-sulfonamide 1,1-dioxide
AKOS016014038
Tox21_110495_1
CCG-214046
DB13284
NCGC00016561-02
NCGC00016561-05
BS-14410
DA-75511
SMR001233468
SBI-0207038.P001
NS00023502
SW197003-3
D01605
E75872
EN300-25597120
Q6824077
SR-01000838874-2
SR-01000838874-3
BRD-K58265391-001-03-6
BRD-K58265391-001-06-9
BRD-K58265391-001-11-9
BRD-K58265391-001-12-7
6-Methyl-3,4-dihydro-2H-thiochromene-7-sulfonamide 1,1-dioxide
3,4-Dihydro-6-methyl-2H-1-benzothiopyran-7-sulfonamide 1,1-dioxide
6-methyl-1,1-dioxo-3,4-dihydro-2H-1??-benzothiopyran-7-sulfonamide
6-methyl-1,1-dioxo-3,4-dihydro-2H-1lambda6-benzothiopyran-7-sulfonamide
214-112-4