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Quinacrine

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Identification
Molecular formula
C23H30ClN3O
CAS number
83-89-6
IUPAC name
(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol
State
State

At room temperature, Quinacrine is in a solid state, characterized by its crystalline appearance and yellow color.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
469.00
Boiling point (Kelvin)
742.15
General information
Molecular weight
343.96g/mol
Molar mass
343.4390g/mol
Density
1.2660g/cm3
Appearence

Quinacrine typically appears as a yellow crystalline solid at room temperature. It may also be available in other forms such as powders or pills when used for its pharmaceutical applications.

Comment on solubility

Solubility of (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol

The solubility of the compound (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol, with the chemical formula C23H30ClN3O, can be characterized by several important features:

  • Polar vs. Nonpolar: The presence of functional groups such as the methanol group suggests that the compound may have some polar characteristics, which can influence its solubility in different solvents.
  • Solvent Compatibility: Generally, compounds with significant nonpolar characteristics tend to have better solubility in nonpolar solvents (e.g., hexane), while those with polar characteristics are more soluble in polar solvents (like water and alcohols).
  • Effect of Substituents: The various substituents, such as the methoxy and vinyl groups, can also affect the overall solubility profile, often increasing solubility in organic solvents due to steric effects and electronic interactions.

In summary, for health-related applications or chemical analysis, understanding the solubility of (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol is essential. It is advisable to conduct solubility tests under specified conditions to evaluate the practical applications of this compound.

Interesting facts

Interesting Facts about (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol

(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol is a compound that exemplifies the fascinating intersection of organic synthesis, medicinal chemistry, and neuropharmacology. Here are some key insights:

  • Diverse Applications: This compound belongs to a class of molecules that have shown potential in various therapeutic areas, including neurological disorders and psychiatric conditions. Its structure allows it to interact with various neurotransmitter systems.
  • Complex Structure: Featuring a quinoline and quinuclidine moiety, the intricate design of this molecule not only demonstrates synthetic ingenuity but also broadens the scope for structural diversity in drug discovery.
  • Mechanism of Action: Compounds similar to (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol often modulate receptors in the brain, potentially acting as ligands that can influence the pathways associated with mood regulation and cognitive function.
  • Synthetic Chemistry: The synthesis of this compound typically involves multiple steps, showcasing reactions such as amination, vinylation, and methylation, highlighting the creativity and skill involved in organic chemistry.
  • Research Potential: Given its unique properties, this compound is an exciting candidate for further scientific investigation. It opens avenues for understanding drug-receptor interactions and could lead to the development of new therapeutic agents.

In conclusion, (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol represents not just a single molecule, but a gateway to understanding more complex biological systems and inspiring future research in medicinal chemistry. As always, the balance between structure and function remains a core principle in the pursuit of pharmaceutical innovation.

Synonyms
9-epi-Quinine
6'-Methoxycinchonan-9-ol
(8alpha,9S)-6'-Methoxycinchonan-9-ol
(6-methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol
Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-
936694-43-8
(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
Quinidine anhydrous
GNF-PF-5473
[5-Ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(6-methoxyquinolin-4-yl)methanol
(5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
(+)-Chinidin
SCHEMBL25528
(R)-(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol
CHEMBL15088
2-Quinuclidinemethanol, .alpha.-(6-methoxy-4-quinolyl)-5-vinyl-
CHEBI:94416
DTXSID40903283
HMS3369K22
HMS3373C19
HMS3751O13
(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
BCP18339
NSC131458
STL356793
AKOS015909346
NSC-131458
PB48768
(1R)((2S,4S,5R)-5-vinylquinuclidin-2-yl)(6-methoxy(4-quinolyl))methan-1-ol
NCGC00015871-03
NCI60_004320
SY014630
SY017339
DB-062785
NS00078016
EN300-717637
L001278
WLN: T66 BNJ HO1 EYQ-DT66 A B CNTJ A1U1
Chinidin; Pitayine; (+)-Quinidine; Quinidex; Chinidin
(6-Methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methanol
.alpha.-(6-Methoxy-4-quinoyl)-5-vinyl-2-quinclidinemethanol