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Halofantrine

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Identification
Molecular formula
C26H30ClNO2
CAS number
69756-53-2
IUPAC name
(6-methoxy-4-quinolyl)-(5-vinyl-2-bicyclo[2.2.2]octanyl)methanol
State
State

At room temperature, Halofantrine is typically in a solid state.

Melting point (Celsius)
144.00
Melting point (Kelvin)
417.15
Boiling point (Celsius)
150.00
Boiling point (Kelvin)
423.15
General information
Molecular weight
502.98g/mol
Molar mass
502.6490g/mol
Density
1.2300g/cm3
Appearence

Halofantrine is a white or almost white crystalline powder. It is odorless and is used as an antimalarial agent.

Comment on solubility

Solubility of (6-methoxy-4-quinolyl)-(5-vinyl-2-bicyclo[2.2.2]octanyl)methanol

The solubility of the compound (6-methoxy-4-quinolyl)-(5-vinyl-2-bicyclo[2.2.2]octanyl)methanol, with the chemical formula C26H30ClNO2, can be influenced by several factors, including its molecular structure and the presence of functional groups. Generally, compounds with complex structures such as this one can exhibit varied solubility in different solvents. Here are some key points regarding its solubility:

  • Polar Solvents: The methanol group in the compound may enhance its solubility in polar solvents due to hydrogen bonding capabilities.
  • Non-Polar Solvents: The bicyclic and quinoline components could render this compound more soluble in non-polar solvents, given the potential for hydrophobic interactions.
  • pH Dependency: Solubility can also vary with pH, especially if the molecule can either donate or accept protons, affecting ionization.

In practical applications, understanding the solubility characteristics is vital as they play a crucial role in bioavailability and pharmaceutical applications. As stated by some researchers, "the solubility of a compound can dictate its effectiveness and usability in various formulations." Therefore, this compound's solubility profile is essential for its effective use in medicinal chemistry and related fields.

Interesting facts

Interesting Facts about (6-methoxy-4-quinolyl)-(5-vinyl-2-bicyclo[2.2.2]octanyl)methanol

(6-methoxy-4-quinolyl)-(5-vinyl-2-bicyclo[2.2.2]octanyl)methanol is a fascinating compound that intertwines the rich chemistry of quinoline structures with unique bicyclic frameworks. Here are some intriguing points to consider:

  • Quinoline Derivative: The compound features a quinoline ring, which is known for its diverse applications in medicinal chemistry. Quinoline derivatives are often investigated for their antimicrobial and anticancer properties.
  • Bicyclic Structures: The reference to a bicyclo[2.2.2]octane system within the molecular framework indicates a level of complexity that can influence the compound's reactivity and interactions. Bicyclic compounds are often characterized by their unusual strain and interesting rotational freedom, leading to unique stereochemistry.
  • Functional Groups: The incorporation of the methoxy group (–OCH3) provides strong electronic influence and can enhance solubility and bioactivity, potentially making this compound suitable for drug development.
  • Potential Applications: Given the structural features of this compound, it may show promise in applications related to pharmaceuticals, particularly in drug design. Its ability to modify biological pathways through the interaction of the quinoline moiety could be key to developing new therapeutic agents.
  • Innovative Synthesis: The synthetic routes to prepare such a compound often involve advanced techniques in organic chemistry, such as C-H activation or cross-coupling reactions, showcasing the ingenuity of modern chemical synthesis.

Overall, the structural complexity and the chemical functionality of (6-methoxy-4-quinolyl)-(5-vinyl-2-bicyclo[2.2.2]octanyl)methanol open a distinctive avenue for research and exploration in both organic synthesis and medicinal chemistry. As a chemistry student or researcher, one can appreciate how such compounds can bridge theoretical knowledge and practical applications.