6-Ethoxy-1,3-benzothiazole-2-sulfonamide

Identification

Molecular formula

C₉H₁₀N₂O₃S₂

CAS number

2971-99-7

IUPAC name

6-ethoxy-1,3-benzothiazole-2-sulfonamide

State

At room temperature, 6-Ethoxy-1,3-benzothiazole-2-sulfonamide is a solid. It is stable under normal conditions, and its resistance to decomposition or reaction makes it useful in a variety of chemical applications, particularly where controlled solubility or reactivity is desired.

Melting point (Celsius)

137.00

Melting point (Kelvin)

410.15

Boiling point (Celsius)

341.00

Boiling point (Kelvin)

614.15

General information

Molecular weight

258.31g/mol

Molar mass

258.3100g/mol

Density

1.5020g/cm³

Appearence

6-Ethoxy-1,3-benzothiazole-2-sulfonamide appears as a crystalline solid, typically in a white to off-white color. This compound is usually supplied in powder form and may exhibit slight yellow or beige tones depending on purity and storage conditions. It is notable for its fine particulate nature and may exhibit a slight aromatic odor.

Comment on solubility

Solubility of 6-ethoxy-1,3-benzothiazole-2-sulfonamide

The solubility of 6-ethoxy-1,3-benzothiazole-2-sulfonamide (C₉H₁₀N₂O₃S₂) is an important aspect to consider in both pharmaceutical and environmental contexts. Here are several key points regarding its solubility:

Aqueous Solubility: This compound exhibits moderate solubility in water, which can be attributed to the presence of the sulfonamide group that generally enhances solubility due to its polar nature.
Solvent Dependency: The solubility may vary significantly depending on the solvent used, showing higher solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO).
pH Sensitivity: The solubility can be influenced by the pH of the solution; in more acidic conditions, the sulfonamide group may protonate, enhancing its solubility.
Pharmaceutical Relevance: Its solubility profile is particularly important for drug formulation, ensuring adequate bioavailability when administered.

Understanding the solubility characteristics of such compounds allows for better predictive modeling in both pharmacokinetics and toxicology.

Interesting facts

Interesting Facts about 6-Ethoxy-1,3-benzothiazole-2-sulfonamide

6-Ethoxy-1,3-benzothiazole-2-sulfonamide is a fascinating compound that sits at the intersection of organic chemistry and medicinal applications. Here are some intriguing insights about this compound:

Versatile Structure: The compound features a unique benzothiazole moiety that is recognized for its potential bioactivity. The presence of both sulfonamide and ethoxy groups contributes to its versatility in various chemical reactions.
Biological Relevance: Sulfonamides are well-known in the pharmaceutical world due to their antibacterial properties. This compound's structure could suggest similar bioactivity, making it a candidate for further medicinal investigation.
Research Potential: Compounds like this have been studied in various contexts, including in vitro assays, to explore their effects on certain biological pathways and diseases, particularly those involving bacterial infections.
Accessibility through Synthesis: The synthesis of 6-ethoxy-1,3-benzothiazole-2-sulfonamide can be achieved through several methods in organic synthesis, providing opportunities for students and researchers to explore synthetic routes and reaction mechanisms.
Chemical Modifications: Scientists may explore further modifications of this compound to enhance its pharmacological properties, potentially leading to the development of new therapeutic agents.

As an interesting side note, sulfur-containing compounds play a crucial role in many biological systems, especially in enzyme function and the synthesis of important biomolecules. The study of compounds like 6-ethoxy-1,3-benzothiazole-2-sulfonamide can provide deeper insights into the chemistry of life.

In conclusion, the exploration of this compound not only deepens our understanding of organic chemistry but also paves the way for potential advances in medical treatments. Its blend of biological relevance and synthetic intrigue makes it a subject worth investigating further!

Synonyms

ethoxzolamide

452-35-7

6-Ethoxy-2-benzothiazolesulfonamide

Ethoxyzolamide

Ethoxazolamide

Ethamide

Cardrase

Etoxzolamide

6-Ethoxy-1,3-benzothiazole-2-sulfonamide

Glaucotensil

Diuretic C

Mingoral

2-Benzothiazolesulfonamide, 6-ethoxy-

6-Ethoxyzolamide

6-Ethoxybenzo[d]thiazole-2-sulfonamide

6-Ethoxybenzothiazole-2-sulfonamide

U-4191

NSC 10679

HSDB 3268

EINECS 207-199-5

NSC-10679

UNII-Z52H4811WX

BRN 0212240

Ethoxzolamide [USP]

DTXSID1023021

AI3-50805

CHEBI:101096

Z52H4811WX

6-Ethoxy-benzothiazole-2-sulfonic acid amide

CHEMBL18

MFCD00057089

Redupresin;L-643786;PNU-4191

MLS000028637

DTXCID303021

4-27-00-04404 (Beilstein Handbook Reference)

NSC10679

Ethoxzolamide (USP)

NCGC00018249-04

Redupresin

SMR000059148

6-Ethoxybenzothiazole-2-sulphonamide

Cardrase (TN)

CAS-452-35-7

EZL

Athamid

3caj

3dcw

3mdz

Ethoxzolamide, EZM

6-Ethoxy-2-benzothiazole8ulfonamide

3dd0

Opera_ID_1207

ETHOXZOLAMIDE [MI]

6-(ethyloxy)-1,3-benzothiazole-2-sulfonamide

ETHOXZOLAMIDE [HSDB]

SCHEMBL63941

MLS001077357

6-Ethoxyzolamide;Ethoxzolamide

ETHOXZOLAMIDE [WHO-DD]

GTPL6814

BDBM10882

HMS2093J03

HMS2094M03

HMS2233N09

HMS3373K15

HMS3715F20

HMS3746M15

Pharmakon1600-01505426

ETHOXZOLAMIDE [ORANGE BOOK]

BCP24088

HY-B1480

Tox21_110848

6-ethoxy-2-benzothiazole sulfonamide

NSC759129

WLN: T56 BN DSJ CSZW GO2

AKOS015915628

Tox21_110848_1

CCG-213432

CS-7836

DB00311

FE61560

NSC-759129

VS-0126

Benzothiazole, 6-ethoxy-2-sulfonamide-

NCGC00018249-01

NCGC00018249-02

NCGC00018249-03

NCGC00018249-05

NCGC00022533-04

NCGC00186657-01

6-Ethoxy-2-benzothiazolesulfonamide, 97%

SBI-0206851.P001

DB-369276

6-Ethoxy-1,3-benzothiazole-2-sulfonamide #

NS00031505

SW220095-1

D02441

G12146

AB00383049_12

AB00383049_13

Q265352

SR-01000000236

SR-01000000236-2

BRD-K18131774-001-10-1

BRD-K18131774-001-17-6

BRD-K18131774-001-18-4

Z995241886

Ethoxzolamide, United States Pharmacopeia (USP) Reference Standard

207-199-5

InChI=1/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13