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Zolpidem

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Identification
Molecular formula
C16H17ClN4O
CAS number
82626-48-0
IUPAC name
6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
State
State
Zolpidem is a solid at room temperature. It is typically formulated into tablets for pharmaceutical use, and in its pure form, usually appears as a crystalline powder. The compound is used medically for its sedative effects.
Melting point (Celsius)
196.50
Melting point (Kelvin)
469.65
Boiling point (Celsius)
506.30
Boiling point (Kelvin)
779.45
General information
Molecular weight
307.79g/mol
Molar mass
307.7890g/mol
Density
1.3900g/cm3
Appearence

Zolpidem is typically found as a white to off-white crystalline powder. This compound is often supplied in tablet form in pharmaceuticals and has no significant odour.

Comment on solubility

Solubility of 6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

The solubility of 6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one (C16H17ClN4O) can be influenced by various factors, particularly its structural characteristics and molecular interactions.

Generally, we can highlight the following aspects regarding its solubility:

  • Polarity: The presence of chlorine and nitrogen atoms can contribute to a certain degree of polarity, which may enhance its solubility in polar solvents.
  • Solvent Compatibility: This compound is likely more soluble in polar organic solvents such as methanol or dimethyl sulfoxide (DMSO) compared to non-polar solvents due to its molecular structure.
  • Hydrogen Bonding: It may have the capacity to engage in hydrogen bonding, further affecting its solubility profile and interaction with various solvents.

In the realm of drug design and formulation, understanding the solubility characteristics of such compounds is crucial, as it often correlates with their bioavailability and therapeutic efficacy. As stated in studies, “The solubility of a drug substantially affects its absorption and distribution within biological systems.”

Understanding the solubility of 6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one is essential for its practical applications in pharmaceutical formulations, underscoring the importance of further experimental analysis to determine its precise solubility metrics.

Interesting facts

Interesting Facts about 6-Chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

This fascinating compound, 6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one, is a member of the imidazoquinazolinone family, which is known for its diverse range of biological activities. Here are some intriguing points regarding this compound:

  • Biological significance: Many compounds in the imidazoquinazolinone class exhibit potential antitumor and antiviral properties, making them subjects of intensive research in medicinal chemistry.
  • Structure: The unique bicyclic structure encompassing both the imidazole and quinazoline rings allows for interesting interactions in biological systems, particularly in enzyme inhibition and receptor binding.
  • Synthetic pathways: The synthesis of this compound often involves innovative strategies in organic synthesis, such as cyclization reactions and the use of various reactive intermediates to achieve the desired molecular architecture.
  • Drug discovery: Compounds like this one are often evaluated in drug discovery programs aimed at developing new therapeutic agents for conditions such as cancer and infectious diseases.
  • Potential challenges: Like many synthesized pharmaceutical compounds, 6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one can present challenges related to stability and solubility in drug formulation, which must be optimized for effective therapeutic use.

In summary, the study of 6-chloro-3-methyl-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one reflects the intricate interplay between chemical structure and biological function, highlighting the importance of this compound in ongoing pharmaceutical research.