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Clotrimazole

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Identification
Molecular formula
C22H17Cl1N2S
CAS number
23593-75-1
IUPAC name
6-chloro-11-methyl-10-(3-methylbut-2-enyl)-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-2-thiol
State
State

At room temperature, clotrimazole is in a solid state. It is typically found as a crystalline powder, which makes it suitable for formulation into creams, lotions, and other pharmaceutical dosage forms.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
395.95g/mol
Molar mass
237.7520g/mol
Density
1.0800g/cm3
Appearence

Clotrimazole appears as a white to pale yellow crystalline powder. It is odorless or may have a slight odor. Its solid form makes it suitable for various pharmaceutical applications, including topical formulations.

Comment on solubility

Solubility of 6-chloro-11-methyl-10-(3-methylbut-2-enyl)-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-2-thiol (C22H17Cl1N2S)

The solubility of the compound C22H17Cl1N2S, also known as 6-chloro-11-methyl-10-(3-methylbut-2-enyl)-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-2-thiol, is quite intriguing due to its complex molecular structure. Several factors affect its solubility:

  • Polarity: The presence of the thiol group (-SH) can contribute to some degree of polarity, which may enhance solubility in polar solvents like water or alcohols.
  • Hydrophobic characteristics: However, the large hydrophobic tricyclic structure may limit its solubility in water, meaning it is likely more soluble in organic solvents such as chloroform or hexane.
  • Temperature effects: Solubility can also vary significantly with temperature; generally, solubility tends to increase with rising temperatures in most solvents.

Experimentation is key, as the actual solubility will depend on the specific conditions under which it is measured. For practical applications and theoretical evaluations, a comprehensive solubility profile can be essential for understanding this compound's behavior in various environments. Thus, it is recommended to perform solubility tests under different conditions for accurate determination.

Interesting facts

Interesting Facts about 6-Chloro-11-methyl-10-(3-methylbut-2-enyl)-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-2-thiol

This fascinating compound is notable for its unique structural features and potential applications in various fields. Here are some interesting facts:

  • Structural Complexity: The compound exhibits a complex tricyclic structure characterized by multiple rings and a triazine moiety, which contributes to its stability and reactivity.
  • Chlorine Substitution: The presence of chlorine in its structure introduces interesting reactivity patterns, which can be exploited for further chemical modifications or in synthesizing related compounds.
  • Thiol Group: The thiol (-SH) functional group is of particular interest in biochemistry. It plays a key role in enzyme activity and can participate in various biochemical processes, making this compound a potential candidate for research in medicinal chemistry.
  • Potential Applications: Due to its unique functional groups, this compound could have implications in anti-cancer research, as many triazine derivatives have shown promising results in therapeutic applications.
  • Versatile Chemistry: The allylic substituent (3-methylbut-2-enyl) opens up avenues for further transformations, making it a useful intermediate in synthetic organic chemistry.

In summary, 6-chloro-11-methyl-10-(3-methylbut-2-enyl)-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-2-thiol is more than just a chemical structure; it represents a blend of complexity and potential that captivates scientists and chemists alike. Future studies could unveil even more exciting properties and applications, keeping this compound at the forefront of chemical research.