Skip to main content

Tenofovir disoproxil

ADVERTISEMENT
Identification
Molecular formula
C19H30N5O10P
CAS number
201341-05-1
IUPAC name
[6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
State
State

At room temperature, Tenofovir disoproxil is in solid state, often available in the form of tablets or as part of combination pills for oral administration.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
519.45g/mol
Molar mass
519.4540g/mol
Density
1.5000g/cm3
Appearence

Tenofovir disoproxil is typically a white to off-white crystalline powder. It is highly soluble in water and also in some organic solvents making it suitable for formulation in different pharmaceutical products.

Comment on solubility

Solubility of [6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate

The solubility of the compound with the formula C19H30N5O10P is influenced by various factors, including its complex structure. Here are some key points to consider regarding its solubility:

  • Polar Nature: The presence of multiple functional groups such as amino and carbonyl groups may enhance the compound's solubility in polar solvents.
  • Hydrophobic Interactions: The butanoyl chain could introduce hydrophobic character, possibly limiting solubility in water while favoring organic solvents.
  • pH Dependency: The solubility might vary with pH, especially due to potential ionization of the amino groups.
  • Temperature Effects: Higher temperatures typically increase solubility for many compounds, which might be relevant in certain applications.
  • Solvent Selection: It is crucial to select appropriate solvents; for instance, dimethyl sulfoxide (DMSO) or other polar aprotic solvents could yield better solubility than water.

Due to its intricate chemical structure, detailed solubility studies would be essential to precisely determine the behavior of this compound in various solvents.

Interesting facts

Interesting Facts about 6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butanoate

This fascinating compound, often explored within the realm of organic chemistry and biochemistry, boasts a unique structure that captures the attention of researchers and students alike. Here are some intriguing aspects:

  • Complex Structure: The compound features a remarkable combination of purine, furan, and phosphinin moieties. This complexity allows it to engage in various chemical interactions, making it a subject of interest in synthetic chemistry.
  • Biological Significance: Due to its purine component, this compound could potentially mimic nucleic acids, which might offer pathways for new pharmaceuticals or bioactive materials. Research indicates that purine derivatives are crucial in numerous biochemical activities, such as energy transfer and signaling.
  • Potential Applications: Compounds like this one can be key players in the development of novel drugs or therapies targeted at metabolic disorders or cancer. The presence of the butanoylamino group may enhance its bioavailability or interaction with biological targets.
  • Phosphorus Chemistry: The dioxaphosphinin structure incorporates phosphorus, an element vital in a myriad of biological processes, including DNA synthesis and energy metabolism. Investigating phosphorus-containing compounds often leads to insights in agricultural and medicinal chemistry.
  • Research Frontier: As scientists continue to unravel the complexities of compound interactions within biological systems, compounds like this one contribute to the expanding library of potential therapeutic agents. The evolution of understanding regarding its mechanisms can lead to groundbreaking discoveries in molecular pharmacology.

The compound's multifaceted nature demonstrates the beautiful interplay between structure and function, allowing it to be a valuable subject for ongoing research and academic inquiry. As we broaden our understanding of such compounds, we embrace the potential for transformative advancements in science and medicine.