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Tenofovir disoproxil

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Identification
Molecular formula
C9H14N5O4P
CAS number
201341-05-1
IUPAC name
[6-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
State
State

Tenofovir disoproxil is generally in a solid state at room temperature. It is supplied in tablet or powder form for oral administration.

Melting point (Celsius)
113.50
Melting point (Kelvin)
386.65
Boiling point (Celsius)
117.50
Boiling point (Kelvin)
390.65
General information
Molecular weight
519.25g/mol
Molar mass
519.2450g/mol
Density
1.4900g/cm3
Appearence

Tenofovir disoproxil is typically a white to off-white crystalline powder.

Comment on solubility

Solubility Profile

The compound [6-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate with the molecular formula C9H14N5O4P exhibits interesting solubility characteristics that can depend on several factors such as pH, temperature, and the presence of solvents.

Generally, its solubility can be summarized as follows:

  • Solvent Compatibility: This compound may be more soluble in polar solvents due to the presence of functional groups, such as amino and hydroxyl groups, which can engage in hydrogen bonding.
  • Influence of pH: The solubility of this compound might significantly vary with changes in pH, especially since it contains nitrogenous bases that can protonate or deprotonate.
  • Temperature Dependence: Increased temperature may enhance solubility, as higher temperatures generally provide more kinetic energy to the solute and solvent molecules.

To quote a relevant observation, “Solubility is not just a property, but rather a transformative capability, influenced by environmental conditions.” Thus, for specific applications, empirical testing is recommended to determine precise solubility under desired conditions.

In conclusion, while the solubility of [6-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate might present challenges, understanding the underlying factors can lead to effectively harnessing its properties in various chemical applications.

Interesting facts

Exploring 6-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butanoate

This compound represents a fascinating intersection of organic chemistry and biochemistry, particularly given its intricate structure and functional groups. Here are some interesting aspects:

  • Phosphorus and Organic Chemistry: This compound contains a phosphorus atom in its structure, which is notable for its role in biological systems, specifically in the formation of DNA and RNA. Phosphorus-containing compounds are essential for cellular processes.
  • Purine Derivative: Known for being part of vital biomolecules, purine derivatives like this one play a significant role in the genetic code. Their structures often facilitate interactions with enzymes and nucleic acids, making them of great interest in medicinal chemistry.
  • Potential Biological Activity: Compounds like this may exhibit biological activities that can be harnessed in pharmaceuticals. Investigating their behavior in biological systems can lead to breakthroughs in drug development.
  • Versatile Functional Groups: The presence of amino and carbonyl groups in the structure enhances its reactivity. Such functionalities can potentially lead to various chemical transformations and applications in organic syntheses.
  • Synthesis and Applications: The complexity of this compound may result in challenging synthetic pathways, but these challenges are what drive innovation in chemical synthesis methodologies. Its potential applications span from pharmaceuticals to agrochemicals.

As we delve deeper into understanding this compound, we might find new applications and insights into its mechanism of action in biological contexts. Exploring the intricacies of its structure could pave the way for future research breakthroughs.

In conclusion, studying 6-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butanoate not only enriches our understanding of chemical compounds but also illustrates the profound connection between chemistry and life sciences.

Synonyms
Cyclic dibutyryl AMP
Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate)2'-butanoate
NCGC00021144-02
N6,5'-phosphate
N6,5'-monophosphate
N6,5'-cyclic AMP
N6,5'-monophosphoric acid
N6,5'-cyclic monophosphate
N6,5'-(hydrogen phosphate)
SCHEMBL163105
3',5'-Dibutyryl cyclic AMP
Dibutyryl cyclic 3',5'-AMP
N6,5'-adenosine monophosphate
CHEMBL1371908
CHEBI:91494
N6,5'-AMP
DTXSID40859352
BCP10476
NSC143108
N6,5'-cyclic adenosine monophosphate
AKOS015896463
NCGC00021144-03
NCGC00094988-01
NCGC00094988-02
NCI60_000948
Dibutyryl 3',5'-cyclic adenosine monophosphate
BRD-A04706586-236-01-7
Q27163331
Butyramide, 2'-butyrate cyclic 3',5'-(hydrogen phosphate)
Butyramide, cyclic 3',5'-(hydrogen phosphate) 2'-butyrate
Bucladesine;3',5'-Cyclic AMP dibutyrate;Cyclic AMP dibutyrate;Dibutyryl 3',5'-Cyclic AMP
6-(6-Butanamido-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butanoate
butanoic acid [2-hydroxy-2-oxo-6-[6-(1-oxobutylamino)-9-purinyl]-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-7-yl] ester