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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
State
State
Tenofovir is a solid at room temperature. It is typically found in powder form and is considered stable under ambient conditions.
Melting point (Celsius)
276.00
Melting point (Kelvin)
549.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
287.21g/mol
Molar mass
287.2090g/mol
Density
1.4900g/cm3
Appearence

Tenofovir appears as a white to off-white powder. It may have a crystalline texture and appears relatively stable under standard conditions of temperature and pressure.

Comment on solubility

Solubility of 6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol (C9H14N5O4P)

The solubility of 6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol is an intriguing and complex topic, primarily influenced by its molecular structure and functional groups. Here are some key points to consider:

  • Polarity: This compound possesses several polar functional groups, including hydroxyl (-OH) and amine (-NH2) groups, which can interact favorably with water molecules, suggesting potential solubility in aqueous environments.
  • Hydrogen Bonding: The presence of hydroxyl groups indicates that it can form hydrogen bonds, which typically enhances solubility in polar solvents.
  • Structural Complexity: The intricate structure may affect the solubility behavior. Compounds with complex ring systems may display varied solubility characteristics based on their conformation and steric hindrance.
  • Solvent Interaction: This compound may exhibit different solubility profiles in organic solvents versus water, emphasizing the importance of the solvent choice in experimental settings.

In summary, while some aspects of solubility suggest that this compound could be more soluble in polar solvents, further experimental data would be essential to accurately characterize its solubility behavior across various media.

Interesting facts

Interesting Facts about 6-(6-Aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

This intriguing compound presents a fascinating intersection of medicinal chemistry and biochemistry, showcasing properties that might have significant implications in drug development and therapeutic applications.

Key Highlights:

  • Aminopurine Derivative: It is derived from the purine base adenine, a crucial component of DNA and RNA, emphasizing its potential biological relevance.
  • Unique Structural Features: The presence of the furo[3,2-d][1,3,2]dioxaphosphinin structure introduces intriguing chemical behavior that can impact the compound's interaction with biological systems.
  • Phosphorus Content: This compound contains phosphorus, which is essential in biological systems and could facilitate its role in biochemical pathways.
  • Therapeutic Potential: Due to its complex structure, it may act as a modulator in biochemical processes, potentially paving the way for novel therapeutic agents in the treatment of cancer, viral infections, or metabolic disorders.
  • Research Interest: Scientists are continuously exploring similar compounds for their pharmacological properties, with a focus on developing more effective and selective drugs.

As a student of chemistry, delving into the properties and applications of such compounds not only enhances your understanding of chemical interactions but also highlights the profound impact that molecular architecture can have on pharmacology and medicinal chemistry. The intricate design of this compound exemplifies the ongoing quest for new therapeutic agents that are safer and more effective in managing diseases. Every step in exploring compounds like this is a step towards unlocking new possibilities in the realm of science.

Synonyms
Acrasin
NSC94017
24493-93-4
6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
Cyclic 9 beta-D-arabinosyladenine 3',5'-monophosphate
Adenosine-3',5'-cyclic phosphate
NSC-94017
Probes1_000341
Probes2_000489
CHEMBL9871
SCHEMBL35371
DTXSID90859044
IVOMOUWHDPKRLL-UHFFFAOYSA-N
Adenosine,5'-(hydrogen phosphate)
BCP19737
NSC127975
AKOS015961067
NSC-127975
AC-12821
NCI60_042098
SY066620
NS00013344
BRD-A41840684-001-01-8
Adenosine 3',5'-cyclophosphate; Cyclic 3',5'-monophosphate adenosine; cAMP
Adenosine 3 inverted exclamation mark ,5 inverted exclamation mark -Cyclic Monophosphate
85187-54-8
86594-34-5