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Tenaofovir Alafenamide

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Identification
Molecular formula
C21H28N5O3P
CAS number
379270-37-8
IUPAC name
6-(6-amino-8-bromo-purin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
State
State

At room temperature, Tenofovir Alafenamide is a solid. It is stable under normal conditions and is typically handled in its solid form during pharmaceutical formulations.

Melting point (Celsius)
82.50
Melting point (Kelvin)
355.65
Boiling point (Celsius)
427.00
Boiling point (Kelvin)
700.15
General information
Molecular weight
476.35g/mol
Molar mass
476.3460g/mol
Density
1.6700g/cm3
Appearence

Tenofovir Alafenamide is a white to off-white powder. It is often used in a solid state as part of oral pharmaceutical preparations.

Comment on solubility

Solubility of 6-(6-amino-8-bromo-purin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

The solubility of the compound with the formula C21H28N5O3P is influenced by various factors including its molecular structure and functional groups. Let's explore key aspects of its solubility:

  • Polarity: The presence of polar functional groups, such as -OH (hydroxyl) and -N (amine), generally enhances solubility in polar solvents like water.

  • Perception of Solubility: Compounds with multiple heteroatoms (like nitrogen in purines and phosphorus) can often exhibit varied solubility characteristics.

  • Solvent Interaction: Understanding how this compound interacts with solvents can give insights into its solubility; it is likely to be soluble in protic solvents while having limited solubility in non-polar solvents due to its overall structure.

  • Temperature Influence: Higher temperatures may increase solubility, a common behavior seen in many organic compounds.

In conclusion, while a specific solubility value for this compound may not be readily accessible, its solubility profile is expected to reflect typical behaviors of similar structured compounds, notably showing increased solubility in polar environments due to its functional groups.

Interesting facts

Interesting Facts about 6-(6-Amino-8-bromo-purin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

This fascinating compound belongs to a unique class of chemical entities known for their diverse applications in biochemistry and medicinal chemistry. Here are several intriguing aspects about it:

  • Structure Complexity: The compound features an elaborate structure, including purine rings and a phosphinate moiety, making it a subject of interest for chemists studying heterocyclic compounds.
  • Potential Applications: It may play a role in drug development, particularly as an inhibitor of certain biological pathways, which could lead to therapeutic benefits in treating various diseases.
  • Pharmacological Interest: Compounds with similar structures are often explored for their potential as anti-cancer or anti-viral agents, highlighting the importance of this compound in pharmaceutical research.
  • Research Opportunities: The presence of multiple functional groups opens up avenues for further functionalization, which could enhance its biological activity or selectivity.
  • Multidisciplinary Relevance: Chemists, biochemists, and pharmacologists can all find value in studying this compound, reflecting the interdisciplinary nature of modern chemistry.

In summary, the exploration of compounds like this one encapsulates the continuous quest for new medicinal agents and the intricate beauty of chemical structures. As noted by a renowned chemist, "The essence of chemistry lies in the diversity of compounds and their transformative potential." This compound surely exemplifies that statement.