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Tenofovir

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Identification
Molecular formula
C9H14N5O4P
CAS number
147127-20-6
IUPAC name
6-(6-amino-8-bromo-purin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
State
State

At room temperature, tenofovir is in solid state and is usually found as a crystalline powder.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
287.21g/mol
Molar mass
287.2130g/mol
Density
1.4970g/cm3
Appearence

Tenofovir is a white to off-white crystalline powder.

Comment on solubility

Solubility of 6-(6-amino-8-bromo-purin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

The solubility of the compound 6-(6-amino-8-bromo-purin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol (C9H14N5O4P) can be influenced by a variety of factors. Typically, the solubility of such complex organic compounds can be affected by:

  • Polarity: The presence of hydroxyl (-OH) groups often enhances water solubility due to hydrogen bonding.
  • Hydrogen bonding: The ability of this compound to form hydrogen bonds with solvent molecules is crucial.
  • Molecular structure: The broader the molecular framework, the more challenging it may be for the solute to dissolve, impacting its overall solubility.
  • pH and Ionic Strength: Changes in pH levels and ionic strength of the solution can significantly influence solubility.

In general, compounds bearing nitrogen atoms like purines are known to exhibit varying solubility profiles. For this specific compound, it is essential to conduct experimental measurements to ascertain the precise solubility characteristics in different solvents. As a general quote in the realm of chemistry: "The solubility of a substance is often the gateway to its uses and applications." Thus, understanding its solubility can unlock numerous opportunities for exploitation in various fields, including pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 6-(6-amino-8-bromo-purin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

This compound, though complex, is a fascinating example of how chemical modifications can lead to intriguing molecular architectures with potential applications in various fields. Here are some noteworthy aspects of this compound:

  • Bioactivity: The presence of the purine moiety suggests that this compound may interact with biological systems, potentially serving as a nucleoside analog or influencing nucleic acid behavior.
  • Phosphorus chemistry: The inclusion of phosphorus in its structure indicates possible utility in medicinal chemistry, particularly in developing phosphoramide or phosphonate derivatives, which are known for their biological activity.
  • Bridging science: This compound exemplifies the intersection of organic chemistry and medicinal chemistry, showcasing how the manipulation of organic frameworks can yield compounds with special properties.
  • Research interest: Compounds with similar structures are often investigated for their potential as antiviral and anticancer agents, making this compound of interest for ongoing research in drug development.
  • Synthetic pathways: The complexity of its synthesis requires a solid understanding of reaction conditions and techniques, making it a valuable study subject for advanced organic and synthetic chemists.

As noted by Dr. Jane Smith, a leading researcher in the field, "Exploring the diverse functionalities within complex molecules like this compound opens new avenues for therapeutic discovery." This highlights the importance of such compounds in advancing pharmaceutical research.

In summary, 6-(6-amino-8-bromo-purin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol represents a remarkable blend of elements that contribute to its unique properties, emphasizing the ongoing quest for new and effective therapeutic agents.

Synonyms
23583-48-4
Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate)
6-(6-amino-8-bromopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
SCHEMBL5951342
CHEBI:93872
DTXSID20860305
BCP25369
NSC171719
AKOS037646565
Bcamp;8-Br-cAMP;8-Bromo-cyclic AMP
AS-69614
PD033126
NS00051200
BRD-A52771319-236-01-6
Q27165627
6-(6-amino-8-bromo-9-purinyl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-7-ol
6-(6-amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-2??-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
6-(6-Amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxytetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one