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2′,3′-Dideoxyadenosine

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Identification
Molecular formula
C10H13N5O3P
CAS number
30516-87-1
IUPAC name
6-[6-amino-8-(6-aminohexylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
State
State

This compound is typically a solid at room temperature. As a nucleoside analog, it is stable under standard atmospheric conditions. Its crystalline nature allows it to be handled as a typical laboratory solid.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.20
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
251.25g/mol
Molar mass
251.2540g/mol
Density
1.7500g/cm3
Appearence

The compound appears as a white crystalline solid, characteristic of many nucleoside analogs. It is usually sold as a powder and may exhibit a slight yellowish tint if impurities are present. It is odorless and has a bitter taste typical of nucleoside drugs.

Comment on solubility

Solubility Overview

The solubility of the compound 6-[6-amino-8-(6-aminohexylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol (C10H13N5O3P) can be characterized by several key factors:

  • Polarity: The presence of multiple functional groups such as amino (–NH2), hydroxy (–OH), and carbonyl (C=O) indicates a degree of polarity, which enhances its solubility in polar solvents.
  • Hydrogen Bonding: The compound's ability to form hydrogen bonds with water molecules suggests that it may have relatively good solubility in aqueous environments.
  • Chain Length: The aminohexylamino chain could introduce moderate hydrophobic characteristics, influencing the overall solubility depending on its length and interaction with the solvent.

In general, while the factors above highlight potential for reasonable solubility, it is essential to note:

  • The actual solubility may vary based on factors like temperature, pH, and the presence of other solutes.
  • Laboratory testing is often necessary to determine the exact solubility limits in various solvents.

As mentioned, understanding solubility is crucial as it directly impacts the compound's bioavailability and effectiveness in applications. Therefore, careful consideration of the described characteristics should be taken into account when working with this compound.

Interesting facts

Interesting Facts about 6-[6-amino-8-(6-aminohexylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol

This intriguing compound is a derivative of purine and belongs to the class of phosphonates, which are well-known for their versatile biological activities. Here are some fascinating aspects of this compound:

  • Biological Importance: Compounds with structural similarities to purines often exhibit significant biochemical roles, especially in cellular processes such as DNA and RNA synthesis.
  • Potential Therapeutic Applications: This compound could be an important molecule in drug design, particularly in the fields of oncology and virology, as purine derivatives are frequently explored for their anticancer and antiviral properties.
  • Structure-Activity Relationship (SAR): The presence of multiple amino groups and the unique furodioxaphosphinin structure may enhance the efficacy and selectivity of the compound, making it a subject of interest in medicinal chemistry.
  • Synergistic Effects: The interaction of this compound with biological molecules, especially enzymes involved in nucleotide metabolism, could yield synergistic effects that enhance therapeutic outcomes.

In the words of a famous chemist: "The beauty of chemistry lies in the unexpected relationships between simple molecules that can lead to profound biological effects." This compound exemplifies that beauty, showcasing potential innovations in pharmaceuticals.

Furthermore, the phosphinate moiety suggests promising properties such as stability and bioavailability, which are critical for pharmaceutical applications. Research into this compound could unravel new pathways for treatment development. Thus, it emphasizes the importance of exploring complex molecules in the quest for novel therapies!

Synonyms
8-AHA-cAMP
39824-30-1
SCHEMBL21581235
WCWLOZYNRVLFOG-UHFFFAOYSA-N
8-(6-aminohexyl)amino-cyclic AMP
8-[(6-Aminohexyl)amino]adenosine cyclic 3',5'-monophosphate