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Spiramycin

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Identification
Molecular formula
C43H74N2O14
CAS number
8025-81-8
IUPAC name
[6-[5-(5-acetoxy-4-hydroxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-10-[5-(dimethylamino)-6-methyl-tetrahydropyran-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] acetate
State
State

At room temperature, spiramycin is typically in a solid state.

Melting point (Celsius)
108.00
Melting point (Kelvin)
381.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
843.04g/mol
Molar mass
843.0390g/mol
Density
1.2000g/cm3
Appearence

Spiramycin generally appears as a white or slightly yellow, crystalline powder.

Comment on solubility

Solubility Overview

The compound 6-[5-(5-acetoxy-4-hydroxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-10-[5-(dimethylamino)-6-methyl-tetrahydropyran-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] acetate (C43H74N2O14) presents a complex structure that influences its solubility profile significantly.

Key Factors Influencing Solubility

Several aspects affect its solubility:

  • Polarity: The presence of hydroxyl (-OH) and dimethylamino groups enhances its ability to interact with polar solvents, suggesting possible solubility in water and alcohols.
  • Hydrophobic Regions: The larger hydrocarbon-like portions may contribute to lower solubility in polar solvents while being more compatible with nonpolar solvents such as hexane.
  • This Substitution Pattern: Multiple ether and ester functional groups can also impact solubility by altering solvation energy and sterics.

Expected Solubility Behavior

In general, one might expect:

  • High solubility in organic solvents like ethanol and acetone.
  • Variable solubility in water, likely moderate due to its amphiphilic characteristics.
  • Limited solubility in purely nonpolar solvents due to the presence of polar groups.

Overall, while this compound has potential solubility in a range of solvents, the actual solubility would need to be empirically determined to account for the complexities of its molecular interactions.

Interesting facts

Interesting Facts about 6-[5-(5-acetoxy-4-hydroxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-10-[5-(dimethylamino)-6-methyl-tetrahydropyran-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] acetate

This compound represents a fascinating area of research in organic chemistry, particularly due to its complex structure that includes various functional groups and stereochemical configurations. Here are some interesting aspects about it:

  • Diverse Functionalities: The compound is characterized by multiple tetrahydropyran units, which are bicyclic structures known for their roles in the synthesis of various bioactive molecules.
  • Potential Biological Activities: Structures like this compound often exhibit important biological activities, leading them to be researched for uses in pharmaceuticals, especially in targeted therapies.
  • Complex Synthesis Pathways: Synthesizing such a multi-substituted molecule poses interesting challenges, encouraging chemists to develop innovative synthetic strategies and utilize multi-step synthesis techniques.
  • Structure-Activity Relationships (SAR): Understanding how the modifications of the tetrahydropyran and acetate moieties affect the biological activity of the compound is key in medicinal chemistry research.
  • Applications in Research: This compound, because of its structural complexity, can serve as a valuable reference in comparative studies to investigate the interactions and dynamics of similar novel compounds in biological systems.

In conclusion, 6-[5-(5-acetoxy-4-hydroxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-10-[5-(dimethylamino)-6-methyl-tetrahydropyran-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] acetate embodies a remarkable blend of complexity and potential, making it an intriguing subject for ongoing scientific exploration.