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Tenofovir disoproxil fumarate

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Identification
Molecular formula
C19H30N5P
CAS number
202138-50-9
IUPAC name
6-[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-dihydroxy-lambda5-phosphanyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid
State
State
The compound is typically a solid at room temperature.
Melting point (Celsius)
118.50
Melting point (Kelvin)
391.70
Boiling point (Celsius)
78.10
Boiling point (Kelvin)
351.30
General information
Molecular weight
635.52g/mol
Molar mass
635.5100g/mol
Density
2.2200g/cm3
Appearence

Tenofovir disoproxil fumarate is a white to off-white crystalline powder.

Comment on solubility

Solubility of 6-[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-dihydroxy-lambda5-phosphanyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid (C19H30N5P)

The solubility of this complex compound is influenced by its unique structural features. Given its polyfunctional nature, it can interact with various solvents through multiple functional groups, leading to diverse solubility behaviors.

Key Factors Influencing Solubility:

  • Hydrophilicity vs. Hydrophobicity: The presence of hydroxyl (-OH) and amino (-NH2) groups generally enhances water solubility.
  • Solvent Choice: It is likely to be soluble in polar solvents (e.g., water, methanol) due to its ionic and polar character.
  • Concentration: At higher concentrations, solubility may decrease due to solute-solute interactions.

In general, the solubility of such biologically active compounds can be pivotal for their efficacy in pharmaceutical applications. As stated, "solubility is often the determining factor for the bioavailability of a drug." This implies that understanding how and why this compound dissolves in specific environments is crucial for effective utilization.

Overall, exploring the solubility characteristics can help in predicting the behavior of this compound in biological systems and various industrial applications.

Interesting facts

Interesting Facts about 6-[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-dihydroxy-lambda5-phosphanyl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid

This complex compound is a fascinating example of how intricate organic molecules can participate in vital biological processes. Here are some intriguing points:

  • Biological Role: This compound has implications in biochemistry, particularly as it relates to nucleotides and cellular energy processes.
  • Phosphorylation: The presence of phosphate groups indicates its involvement in phosphorylation reactions, which are crucial for signaling pathways in cells.
  • Structural Diversity: Its structure includes elements such as purine and tetrahydrofuran, showcasing the compound’s diversity in functional groups which may enhance biological activity.
  • Potential Applications: Due to its complex structure, it could be a candidate for therapeutic applications, particularly in cancer research or antibiotic development.
  • Research Interest: Given the growing interest in nucleoside analogs in medicinal chemistry, compounds like this can provide pathways to novel treatments and drug designs.
  • Synthesis Challenges: The synthesis of such complex molecules often requires advanced synthetic techniques, making them favorites among chemists who thrive on challenging projects.

As quoted by famed chemist Henry Taube, "Chemistry is the science of matter, and the matter of life consists of the most intricate molecules." This specific instance emphasizes the elegance and complexity of life at a molecular level, making it a point of study that sparks curiosity among chemists and biologists alike.

Overall, the exploration of such compounds not only enhances our understanding of chemical interactions but also opens pathways to innovations in medical science.