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6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

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Identification
Molecular formula
C11H11BrN2S
CAS number
141445-25-6
IUPAC name
6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
State
State

At room temperature, this compound is typically in a solid state.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
270.19g/mol
Molar mass
270.1870g/mol
Density
1.4800g/cm3
Appearence

The compound presents as a white to off-white solid in pure form. It may be crystalline in nature depending on its method of synthesis and purification.

Comment on solubility

Solubility of 6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (C11H11BrN2S)

The solubility of chemical compounds can vastly influence their application in various fields, particularly in pharmaceuticals and materials science. For 6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole, the solubility characteristics can be summarized as follows:

  • Polar vs. Nonpolar Solvents: Compounds like this one, which possess a bromine atom and a thiazole ring, are typically more soluble in polar organic solvents compared to nonpolar solvents.
  • Influence of Bromine: The presence of the bromine atom may enhance solubility in certain solvents due to its electronegative properties, which can influence intermolecular interactions.
  • Hydrophilicity vs. Hydrophobicity: The balance between the hydrophilic (water-attracting) and hydrophobic (water-repelling) portions of the molecule affects its solubility. This compound may exhibit low to moderate solubility in water, primarily due to its hydrophobic characteristics.
  • Crystallization: Crystallization tendencies can also be affected by the solubility profile. A low solubility can suggest that the compound may readily crystallize in certain conditions, impacting its bioavailability.

In conclusion, the solubility of 6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole can largely be predicted by evaluating its molecular structure and the nature of its substituents. As always, direct experimental measurements are recommended to ascertain the precise solubility parameters in relevant solvents.

Interesting facts

Interesting Facts about 6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

This compound, known as 6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole, is an intriguing member of the imidazothiazole class. Its complex structure contains both imidazole and thiazole rings, making it a subject of interest for researchers in medicinal chemistry.

Chemical Properties and Applications

  • Pharmacological Potential: Compounds similar to this structure have been studied for their biological activities, including anti-cancer and anti-inflammatory properties.
  • Role in Research: This compound can serve as a pharmacophore in drug design, giving rise to new derivatives with optimized biological activity.
  • Industries: Beyond pharmaceuticals, derivatives of imidazothiazoles are also explored in agrochemicals and materials science.

Structural Features

The presence of bromine on the phenyl group enhances the compound’s reactivity, enabling it to engage in various chemical reactions, which can lead to the creation of novel compounds with varied applications. Moreover, the tetrahydro configuration contributes to its unique three-dimensional arrangement, impacting its interactions at the molecular level.

Historical Significance

The exploration of thiazole derivatives dates back several decades, and compounds like 6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole contribute to our ongoing understanding of heterocyclic chemistry.

As scientists continue to unveil the vast potentials of such intricate compounds, the bridge between structure and biological activity remains a critical focal point in the development of new therapeutic agents.

Synonyms
6646-46-4
4-bromotetramisole
6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
imidazo[2,1-b]thiazole, 6-(4-bromophenyl)-2,3,5,6-tetrahydro-
6-(4-bromophenyl)-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole
6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
6-Bromolevamisole
V3Q75W2536
Imidazo(2,1-b)thiazole, 6-(4-bromophenyl)-2,3,5,6-tetrahydro-
p-Bromotetramisole
D-4-Bromotetramisole
L-4-Bromotetramisole
1-(para-Bromotetramisole)
6-(4-bromophenyl)-2H,3H,5H,6H-imidazo(2,1-b)(1,3)thiazole
(+/-)-4-bromotetramisole
SCHEMBL9281894
CHEMBL3302525
UNII-V3Q75W2536
DTXSID20985103
HTHGAIADRJRJOY-UHFFFAOYSA-N
(+/-)-P-BROMOTETRAMISOLE
GAA64646
AKOS015961829
4-BROMOTETRAMISOLE, (+/-)-
AC-14900
EN300-191712
Q27291499
Z1509589658
871-234-6