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Atorvastatin

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Identification
Molecular formula
C33H35FN2O5
CAS number
134523-00-5
IUPAC name
6-[4-(4-fluorophenyl)phenyl]-4-[[3-methyl-1-(phenylcarbamoyl)butyl]carbamoyl]-2-[4-(1-oxoisoindolin-2-yl)butyl]hexanoic acid
State
State

At room temperature, atorvastatin is typically found in its solid form. Being a crystalline compound, it retains its shape and firmness under standard conditions.

Melting point (Celsius)
159.50
Melting point (Kelvin)
432.65
Boiling point (Celsius)
778.30
Boiling point (Kelvin)
1 051.45
General information
Molecular weight
558.65g/mol
Molar mass
1 209.4200g/mol
Density
1.1000g/cm3
Appearence

Atorvastatin commonly appears as a white or off-white crystalline powder. It is not significantly hygroscopic, making it suitable for pharmaceutical use.

Comment on solubility

Solubility of 6-[4-(4-fluorophenyl)phenyl]-4-[[3-methyl-1-(phenylcarbamoyl)butyl]carbamoyl]-2-[4-(1-oxoisoindolin-2-yl)butyl]hexanoic acid

The solubility of the compound with the formula C33H35FN2O5 is characterized by a complex interplay of molecular features that influence how it interacts with solvents. Understanding its solubility can be crucial for applications involving drug formulations, chemical reactions, and environmental science.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups, such as the carbamoyl and carboxylic acid moieties, suggests that the compound may exhibit some degree of solubility in polar solvents like water and methanol.
  • Hydrophobic Regions: With a large hydrophobic structure primarily composed of aromatic rings, this compound's solubility might be considerably higher in non-polar solvents such as dichloromethane or hexane.
  • Temperature Effects: Increased temperature typically enhances solubility for many organic compounds; hence, one might expect this compound to dissolve better at elevated temperatures.
  • pH Levels: The carboxylic acid functionality implies that solubility can also be affected by changes in pH, notably becoming more soluble in a basic environment due to deprotonation.

In summary, the solubility of this compound is influenced by its heterogenous structure, with both hydrophilic and hydrophobic characteristics at play. This duality can lead to unpredictable solubility behaviors, making qualitative and quantitative assessments essential for practical applications. As the saying goes, "Like dissolves like," and understanding the balance of polar and non-polar portions is key to predicting its solubility in various solvents.

Interesting facts

Interesting Facts about 6-[4-(4-fluorophenyl)phenyl]-4-[[3-methyl-1-(phenylcarbamoyl)butyl]carbamoyl]-2-[4-(1-oxoisoindolin-2-yl)butyl]hexanoic acid

This fascinating compound, often referenced in the context of medicinal chemistry, showcases the intricate relationship between chemical structure and biological activity. Here are some notable aspects:

  • Pharmacological Potential: The compound features several functional groups that may interact with biological targets, making it a subject of interest in drug development.
  • Fluorine Atoms: The presence of a fluorine atom in its structure can significantly enhance the compound's metabolic stability and lipophilicity, which are crucial for pharmacokinetics.
  • Complex Architecture: The multi-ring structure, which includes isoindole moieties and various carbon chains, suggests that this molecule could exhibit unique mechanisms of action.
  • Carbamoyl Groups: The carbamoyl units may contribute to the ability of the compound to form hydrogen bonds, enhancing its reactivity and interaction with enzymes or receptors in the body.
  • Potential Applications: Such compounds can be evaluated for various therapeutic applications including anti-cancer activity, anti-inflammatory properties, and central nervous system effects.

As noted by chemists, "The properties of a compound are defined not only by its components but also by how they are arranged." This principle holds true for this compound, as its detailed structure suggests a wealth of possibilities for exploration in both synthetic and applied chemistry.

In conclusion, 6-[4-(4-fluorophenyl)phenyl]-4-[[3-methyl-1-(phenylcarbamoyl)butyl]carbamoyl]-2-[4-(1-oxoisoindolin-2-yl)butyl]hexanoic acid epitomizes the exciting challenge that chemists face: unraveling the mysteries of complex organic molecules in the quest for meaningful applications in health and technology.