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Sunitinib

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Identification
Molecular formula
C22H27N3O4
CAS number
557795-19-4
IUPAC name
6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
State
State

Sunitinib is in a solid state at room temperature.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
785.30
Boiling point (Kelvin)
1 058.45
General information
Molecular weight
398.48g/mol
Molar mass
398.4750g/mol
Density
1.3830g/cm3
Appearence

Sunitinib is typically a yellow to orange crystalline solid.

Comment on solubility

Solubility of 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one

The solubility of the compound 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one (C22H27N3O4) can be influenced by several factors, including its structure and the nature of the functional groups present.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups, such as the methoxy groups, can enhance solubility in polar solvents like water.
  • Molecular Size: The relatively large molecular size may limit solubility in some solvents due to steric hindrance.
  • Hydrogen Bonding: The potential for hydrogen bonding can play a crucial role in solubility, allowing interactions with solvent molecules.

With regard to the **solvent systems**, this compound is expected to demonstrate variable solubility characteristics:

  • Readily soluble in alcohols and organic solvents due to hydrophobic regions.
  • Limited solubility in non-polar solvents, reflecting its partly polar nature.
  • *Highly soluble* in aqueous solutions, especially when exposed to environmental conditions that promote ionization.

In conclusion, the solubility of 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one is contingent upon both its molecular architecture and the environmental conditions. As stated, "Understanding solubility behavior is essential for optimizing the performance and application of chemical compounds."

Interesting facts

Interesting Facts about 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one

This compound is a fascinating member of the quinoline family, which is known for its diverse biological activities. The structural complexity of this compound lends itself to a myriad of intriguing properties and potential applications in various fields.

Key Features

  • Pharmacological Potential: Quinoline derivatives have been extensively studied for their pharmacological properties, including their roles as potential anti-cancer agents, anti-inflammatory drugs, and anti-viral compounds.
  • Structural Motifs: The inclusion of a piperazine moiety is noteworthy as this structural feature is often found in many pharmacologically active compounds, enhancing receptor binding and biological activity.
  • Dimethoxy Group: The 3,4-dimethoxybenzoyl group contributes to the lipophilicity of the compound, which can significantly influence its absorption and distribution in biological systems.

Applications in Research

Given its intricate molecular architecture, this compound is often explored in:

  • Drug Discovery: Researchers are particularly interested in derivatives of this compound for developing new therapeutic agents.
  • Medicinal Chemistry: Its unique structure serves as a valuable template for the synthesis of new ligand analogs that may exhibit enhanced biological activities.

Quote to Consider

As stated by a prominent chemist, "The beauty of medicinal chemistry lies in the endless possibilities of modification and the resulting diversity in function." This compound exemplifies this philosophy.

In conclusion, 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one stands as a testament to the intricate interplay between structure and function in the realm of chemical compounds. Its ongoing study is essential for advancing knowledge in both chemistry and pharmacology.

Synonyms
vesnarinone
81840-15-5
Arkin-Z
OPC-8212
Piteranometozine
Vesnarinona
Arkin
Vesnarinonum
Vesnarinonum [Latin]
Vesnarinona [Spanish]
Arkin Z
6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
Vesnarinone [USAN:INN:JAN]
CCRIS 1451
DRG-0210
5COW40EV8M
BRN 5644229
Arkin Z (TN)
VESNARINONE [MI]
VESNARINONE [INN]
VESNARINONE [JAN]
VESNARINONE [USAN]
VESNARINONE [VANDF]
VESNARINONE [MART.]
6-(4-(3,4-dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one
6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1h)-quinolinone
VESNARINONE [WHO-DD]
CHEMBL17423
DTXSID80231411
1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone
Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-
Vesnarinonum (Latin)
VESNARINONE (MART.)
pieranometazine
OPC 8212
6-{4-[(3,4-dimethoxyphenyl)carbonyl]piperazin-1-yl}-1,2,3,4-tetrahydroquinolin-2-one
UNII-5COW40EV8M
6-(4-((3,4-dimethoxyphenyl)carbonyl)piperazin-1-yl)-1,2,3,4-tetrahydroquinolin-2-one
MFCD00867124
Arkin (TN)
1-(1,2,3,4-Tetrahydro-2-oxo-6-quinolyl)-4-veratroylpiperazine
6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-
Vesnarinone(OPC8212)?
3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinone
SCHEMBL50993
Vesnarinone (JAN/USAN/INN)
CHEBI:31237
DTXCID80153902
EX-A718
GLXC-03078
BCP15943
BDBM50016980
OPC-8212; Piteranometozine; Arkin
6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-quinolone
AKOS027475338
CS-5387
DB12082
NCGC00510509-02
HY-15297
MS-26657
DB-056556
NS00069189
OPC 8212;OPC-8212;OPC8212
D01690
Q7923264
BRD-K13414800-001-01-3
6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril
[4-(3,4-Dihydro-quinolin-6-yl)-piperazin-1-yl]-(3,4-dimethoxy-phenyl)-methanone
3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip-erazinyl)-2(1H)-quinolinone
3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2-(1H)-quinolinone
6-[4-(3,4-Dimethoxy-benzoyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
6-[4-(3,4-Dimethoxy-benzoyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one(OPC-8212)
Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydr-o-2-oxo-6-quinolinyl)