Thiabendazole | Solubility of Things

Identification

Molecular formula

C₁₀H₇N₃O₂S

CAS number

148-79-8

IUPAC name

6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine

State

At room temperature, thiabendazole is found in a solid state. It is usually crystalline in nature and is stable under normal conditions.

Melting point (Celsius)

296.00

Melting point (Kelvin)

569.15

Boiling point (Celsius)

385.00

Boiling point (Kelvin)

658.15

General information

Molecular weight

201.24g/mol

Molar mass

201.2430g/mol

Density

1.3100g/cm³

Appearence

Thiabendazole is a white to off-white crystalline powder. It is typically odorless and displays a bitter taste.

Comment on solubility

Solubility of 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine

The solubility of the compound 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine (C₁₀H₇N₃O₂S) can be influenced by several factors. Its complex structure suggests interesting solubility behavior:

Polar vs. Non-polar Solvents: This compound contains both polar and non-polar characteristics due to the presence of the nitro group as well as the imidazole ring. Thus, it is likely to exhibit:

Solubility in polar solvents, such as water or methanol, due to hydrogen bonding capabilities.
Limited solubility in non-polar solvents, which fail to interact effectively with its molecular structure.

pH Dependency: The solubility might be affected by the pH of the solution:

Acidic conditions could enhance solubility by protonating the nitro group, increasing interaction with solvent molecules.
Basic conditions might lead to precipitation or reduced solubility due to deprotonation effects.

Temperature Influence: Increased temperature generally enhances solubility for many compounds, and it might be an effective method for dissolving this purine derivative.

In conclusion, understanding the solubility profile of 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine is crucial for applications in fields like medicinal chemistry, where solubility can significantly affect bioavailability and efficacy. As a summary:

Expect good solubility in polar solvents.
Monitor pH for optimal solubility conditions.
Consider temperature variations for enhanced dissolution.

Interesting facts

Interesting Facts about 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine

This fascinating compound, known for its unique structural features, is a derivative of purine, which is one of the building blocks of nucleic acids like DNA and RNA. Its complex structure includes both nitro and imidazole groups, which impart interesting chemical properties and biological activity.

Key Highlights:

Biological Relevance: Purine derivatives are significant in cellular processes, making this compound potentially important in pharmacology and biochemistry.
Antimicrobial Potential: Compounds containing imidazole and nitro groups have exhibited antimicrobial properties, potentially paving the way for new antibacterial agents.
Drug Development: The presence of various functional groups suggests that this compound could be a candidate for drug development, especially against resistant pathogens.
Mechanism of Action: This compound’s structure might influence its interaction with biological targets, affecting enzyme activity or cellular signaling pathways.

As noted by researchers, “exploring the multifaceted nature of purine derivatives can lead to groundbreaking discoveries in medicine.” This compound's unique chemical makeup not only attributes to its biological activities but also makes it a key subject of study in medicinal chemistry. The ongoing research on such compounds highlights the significance of understanding chemical interactions at the molecular level.

Overall, the exploration of 6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-7H-purine opens new avenues in both fundamental science and applied medicine, showcasing the ever-evolving relationship between chemistry and health.

Synonyms

azathioprine

446-86-6

Imuran

Azothioprine

Azathioprin

Azamun

Azanin

Azatioprin

Azasan

Ccucol

Imurek

Imurel

Muran

Azathiopurine

Rorasul

Azathioprinum

Azatioprina

NSC-39084

BW 57-322

BW-57-322

6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine

NCI-C03474

NSC 39084

Methylnitroimidazolylmercaptopurine

6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine

Azathioprinum [INN-Latin]

Azatioprina [INN-Spanish]

CCRIS 62

Imuran (TN)

6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine

6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine

6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine

HSDB 7084

6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine

Purine, 6-(1-methyl-4-nitro-5-imidazolylthio)-

1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-

UNII-MRK240IY2L

6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine

6-(Methyl-p-nitro-5-imidazolyl)-thiopurine

EINECS 207-175-4

MRK240IY2L

6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-9H-purine

Azathioprine (Azasan, Imuran)

CHEBI:2948

DTXSID4020119

6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine

AI3-50290

6-(1-Methyl-4-nitroimidazol-5-ylthio)purin

1H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-

Purine, 6-((1-methyl-4-nitroimidazol-5-yl)thio)-

BW 57322

DTXCID00119

Azamun [Czech]

6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine

B. W. 57-322

6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine

NSC39084

6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine

6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-7H-purine

6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine

Azathioprine [USAN:USP:INN:BAN:JAN]

NCGC00015060-06

NCGC00015060-14

CAS-446-86-6

6-(1-Methyl-4-nitroimidazol-5-ylthio)purine

AZATHIOPRINE (IARC)

AZATHIOPRINE [IARC]

Azathioprinum (INN-Latin)

Azatioprina (INN-Spanish)

AZATHIOPRINE (MART.)

AZATHIOPRINE [MART.]

AZATHIOPRINE (USP-RS)

AZATHIOPRINE [USP-RS]

6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine

Azamune

AZATHIOPRINE (EP IMPURITY)

AZATHIOPRINE [EP IMPURITY]

AZATHIOPRINE (EP MONOGRAPH)

AZATHIOPRINE [EP MONOGRAPH]

AZATHIOPRINE (USP MONOGRAPH)

AZATHIOPRINE [USP MONOGRAPH]

1H-PURINE, 6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)

Azathioprine (USAN:USP:INN:BAN:JAN)

6-((1-METHYL-4-NITROIMIDAZOL-5-YL)THIO)PURINE6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)-1H-PURINE

Azasan (TN)

SR-01000075537

Purine, 6-[(1-methyl-4-nitroimidazol-5-yl)thio]-

MFCD00069203

6-(1-methyl-4-nitro-1H-imidazol-5-ylthio)-9H-purine

azanine

6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]

Azothioprin

Jayempi

6-((1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl)-7H-purine

Azoran

Zytrim

Prestwick_41

Azathiopurine,(S)

Jayempi (TN)

[Methyl(nitroimidazolyl)mercaptopurine]

Spectrum_000064

Azathioprine (Standard)

Azathioprine, >=98%

6-(Methyl-p-nitro-5-imidazolyl)thiopurine

Prestwick0_000094

Prestwick1_000094

Prestwick2_000094

Prestwick3_000094

Spectrum2_000068

Spectrum3_000308

Spectrum4_000243

Spectrum5_000848

AZATHIOPRINE [MI]

Lopac-A-4638

ChemDiv1_002659

6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine

AZATHIOPRINE [INN]

AZATHIOPRINE [JAN]

A 4638

AZATHIOPRINE [HSDB]

AZATHIOPRINE [USAN]

Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl)

SCHEMBL4278

AZATHIOPRINE [VANDF]

CHEMBL1542

6-(1-methyl-4-nitro-5-imidazolyl)mercaptopurine

Lopac0_000027

Oprea1_375441

Oprea1_533384

Oprea1_633462

BSPBio_000048

BSPBio_001876

CBDivE_013132

KBioGR_000646

KBioGR_002427

KBioSS_000464

KBioSS_002433

AI-981/34845012

MLS001049307

AZATHIOPRINE [WHO-DD]

AZATHIOPRINE [WHO-IP]

DivK1c_000586

SPECTRUM1500133

SPBio_000255

SPBio_001987

BPBio1_000054

GTPL7120

Azathioprine (JP18/USP/INN)

Azathioprine - Bio-X trade mark

HMS501N08

HMS594I19

HY-B0256R

KBio1_000586

KBio2_000464

KBio2_002427

KBio2_003032

KBio2_004995

KBio2_005600

KBio2_007563

KBio3_001376

KBio3_002906

L04AX01

cMAP_000046

NINDS_000586

AZATHIOPRINE [ORANGE BOOK]

HMS1568C10

HMS1920E17

HMS2091K19

HMS2095C10

HMS2802J03

HMS3259P03

HMS3260E15

HMS3655M04

HMS3712C10

Pharmakon1600-01500133

BCP09492

HY-B0256

Tox21_110074

Tox21_400024

Tox21_500027

AZATHIOPRINUM [WHO-IP LATIN]

BDBM50373919

CCG-16168

CCG-39877

MFCD00055974

NSC755900

s1721

STK831906

AKOS005609209

AKOS028108935

Tox21_110074_1

AC-4230

CCG-220094

DB00993

FA18064

KS-1146

LP00027

NC00614

NSC-755900

SDCCGMLS-0065415.P001

SDCCGSBI-0050016.P005

IDI1_000586

NCGC00015060-01

NCGC00015060-02

NCGC00015060-03

NCGC00015060-04

NCGC00015060-05

NCGC00015060-07

NCGC00015060-08

NCGC00015060-09

NCGC00015060-10

NCGC00015060-11

NCGC00015060-12

NCGC00015060-13

NCGC00015060-15

NCGC00015060-16

NCGC00015060-18

NCGC00015060-19

NCGC00015060-29

NCGC00090836-01

NCGC00090836-02

NCGC00090836-03

NCGC00090836-04

NCGC00090836-05

NCGC00090836-06

NCGC00094593-01

NCGC00094593-02

NCGC00094593-03

NCGC00260712-01

BA166065

SMR000427366

6-1'-Methyl,5'-imidazolyl mercaptopurine

SBI-0050016.P003

Azathioprine 100 microg/mL in Acetonitrile

6-(1-Methyl-4-nitromidazol-5-ylthio)purine

A2069

AB00443544

EU-0100027

NS00004945

SW198560-2

Azathioprine, meets USP testing specifications

C06837

D00238

D70170

EN300-118702

Q18939

AB00443544-03

AB00443544-11

AB00443544_12

AB00443544_13

AG-670/36150031

SR-01000762955

6-(1-Methyl-4-nitro-1H-imidazol-5-ylthio)purine

6-(1-Methyl-4-nitro-5-imidazolythio)-9H-pur-ine

SR-01000075537-1

SR-01000075537-4

SR-01000762955-2

BRD-K32821942-001-05-6

BRD-K32821942-001-10-6

BRD-K32821942-001-20-5

BRD-K32821942-001-21-3

BRD-K60324116-001-01-5

WLN: T56 BM DN FN HNJ IS- ET5N CNJ A1 DNW

Z57063156

6-(3-methyl-5-nitro-imidazol-4-yl)sulfanyl-9H-purine

6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-1H-purine

6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-9H-purine

9H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-

Azathioprine, European Pharmacopoeia (EP) Reference Standard

1H-PURINE, 6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO-

6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-1H-purine #

Azathioprine, United States Pharmacopeia (USP) Reference Standard

6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine;BW-57-322;NSC-39084

Azathioprine, Pharmaceutical Secondary Standard; Certified Reference Material

207-175-4