Skip to main content

Thymidine

ADVERTISEMENT
Identification
Molecular formula
C10H14N2O5
CAS number
50-89-5
IUPAC name
6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione
State
State

At room temperature, thymidine exists as a solid.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
504.00
Boiling point (Kelvin)
777.15
General information
Molecular weight
242.23g/mol
Molar mass
242.2280g/mol
Density
1.1800g/cm3
Appearence

Thymidine appears as a white, crystalline powder. It is generally odorless.

Comment on solubility

Solubility of 6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione

The solubility of the compound 6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione (C10H14N2O5) is influenced by several key factors:

  • Polarity: The presence of hydroxyl (-OH) groups increases the polarity of the molecule, potentially enhancing solubility in polar solvents such as water.
  • Hydrogen Bonding: The compound can engage in hydrogen bonding due to its hydroxyl groups, which usually improves solubility in aqueous solutions.
  • Molecular Weight: With a molecular formula that suggests a moderate molecular weight, the compound's solubility may be affected by its overall structure and the distribution of hydrophilic and hydrophobic regions.
  • Temperature Dependency: Like many organic compounds, solubility can vary with temperature; thus, higher temperatures might increase the solubility of this compound in various solvents.

In summary, while specific data on the solubility of 6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione is limited, the compound's structure suggests a potential for good solubility in polar solvents. As with many organic compounds, the interactions with solvent molecules will play a crucial role in determining its solubility behavior.

Interesting facts

Interesting Facts about 6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione

6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione is a fascinating compound with diverse applications in the field of chemistry and medicine. This compound belongs to the pyrimidine class, which is a vital structure in numerous biological systems and pharmaceuticals. Here are some engaging aspects of this compound:

  • Biological Significance: Pyrimidine derivatives are essential components of nucleic acids, making compounds like this one critical for DNA and RNA synthesis. They play a pivotal role in genetic information transfer.
  • Pharmaceutical Applications: Many compounds similar in structure to this one have been explored for their anti-cancer and anti-viral properties. This prompts further research which could lead to new therapeutic agents.
  • Synthetic Utility: The hydroxypropyl group present in this molecule enhances its solubility and bioavailability, suggesting potential for formulation in drug delivery systems.
  • Structure-Activity Relationships (SAR): Understanding how structural changes influence the activity of compounds in this category is crucial. This compound serves as a model for studying the effects of substituents on biological activity.
  • Unexplored Potential: Despite its interesting properties, the full potential of this compound remains under investigation, indicating a rich avenue for future research in drug design and discovery.

As a future chemist, delving into the world of pyrimidines offers a window into the interconnectedness of structure, function, and application, showcasing how subtle changes in molecular architecture can lead to significant differences in biological activity and therapeutic potential.

Synonyms
6-hydroxypropylthymine
6-(3-hydroxypropyl)thymine
6-(3-hydroxypropyl)-5-methylpyrimidine-2,4(1H,3H)-dione
E5AK9SKZ52
CHEBI:43299
6-(3-hydroxypropyl)-5-methyl-1H-pyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione, 6-(3-hydroxypropyl)-5-methyl-
156569-47-0
SCHEMBL4315838
DB04139
PD006936
NS00068868
Q27094979
5-Methyl-6-(3-oxidanylpropyl)-1H-pyrimidine-2,4-dione
6-(3-Hydroxypropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione