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Buspirone

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Identification
Molecular formula
C21H31N5O2
CAS number
36505-84-7
IUPAC name
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3,5-trimethyl-pyrimidine-2,4-dione
State
State

Buspirone is usually found in a solid state, particularly as a powder, at room temperature.

Melting point (Celsius)
190.50
Melting point (Kelvin)
463.65
Boiling point (Celsius)
544.49
Boiling point (Kelvin)
817.64
General information
Molecular weight
385.51g/mol
Molar mass
385.5050g/mol
Density
1.0996g/cm3
Appearence

Buspirone is a white, crystalline powder that is sparingly soluble in water and very soluble in methanol and in chloroform. It appears as an off-white to beige solid.

Comment on solubility

Solubility of 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3,5-trimethyl-pyrimidine-2,4-dione

The solubility of the compound with the formula C21H31N5O2 can be understood through several key factors:

  • Polar and Nonpolar Characteristics: This compound contains both polar functional groups, such as the amine and carbonyl groups, and nonpolar hydrocarbon chains. This dual nature suggests that it might display varying levels of solubility in different solvents.
  • Solvent Interactions: Due to the presence of the piperazine and methoxyphenyl groups, it is likely to be more soluble in polar solvents like water and alcohols, while possibly exhibiting lower solubility in nonpolar solvents like hexane or toluene.
  • Temperature Influence: Like many organic compounds, its solubility can be affected by temperature. Generally, an increase in temperature tends to improve solubility, so analyzing its behavior under various thermal conditions is essential.
  • pH Effects: The solubility of this compound may vary with changes in pH due to potential protonation of amine groups, which can enhance water solubility in acidic conditions.

In summary, the solubility of this compound is dependent on its structural features, the solvent's properties, and external conditions, making it an intriguing subject for further study. Such investigations are vital for understanding its behavior in biological and chemical environments.

Interesting facts

Interesting Facts about 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3,5-trimethyl-pyrimidine-2,4-dione

This compound represents a fascinating intersection of organic chemistry and medicinal science. Its complex structure is characterized by the presence of multiple functional groups, making it a valuable subject for investigation.

Key Features:

  • Pyrimidine Core: This compound contains a pyrimidine ring, a six-membered ring with two nitrogen atoms, which is often found in various biologically active molecules.
  • Diverse Functionalities: The incorporation of a piperazine moiety suggests potential for neuropharmacological activity, as piperazine derivatives are frequently utilized in drug discovery for treating mental health conditions.
  • Phenyl Substitution: The methoxyphenyl group enhances the lipophilicity of the compound, which can influence its interaction with biological membranes and potentially affect its pharmacokinetics.

This compound is particularly noteworthy in the realm of drug development. The following aspects can be considered:

Applications in Research:

  • Potential Therapeutic Uses: Compounds of this nature may exhibit promise in treating various conditions such as anxiety, depression, or other neurological disorders.
  • Mechanistic Insights: Studying derivatives like this offers insights into how modifications in chemical structure can influence biological activity and efficacy.
  • Pharmacodynamics and Pharmacokinetics: Understanding how this compound behaves in biological systems could lead to valuable knowledge in the design of future therapeutics.

As one researcher articulated, “The exploration of complex pharmaceutical compounds not only broadens our understanding of chemistry but also illuminates new pathways to healing.” This highlights the significance of investigating such compounds further.

In conclusion, the unique composition and potential applications of 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3,5-trimethyl-pyrimidine-2,4-dione make it a compelling candidate for research and development in modern medicinal chemistry.

Synonyms
5-Methylurapidil
34661-85-3
5-Methyl-urapidil
Urapidil, 5-Methyl-
5 Methylurapidil
Urapidil-5-methyl
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3,5-trimethylpyrimidine-2,4-dione
UNII-1HLS600135
1HLS600135
CHEMBL420060
6-((3-(4-(2-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3,5-trimethyl-
5-METHYL-6((3-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)PROPYL)-AMINO)-1,3-DIMETHYLURACIL
6-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propylamino)-1,3,5-trimethylpyrimidine-2,4-dione
Lopac-U-101
Lopac0_001275
GTPL489
URAPIDIL 5-METHYL-
MLS000860044
SCHEMBL6375436
DTXSID60956150
HIHZDNKKIUQQSC-UHFFFAOYSA-N
HMS2232C19
HMS3263P12
HMS3373B21
Tox21_501275
BDBM50033112
MFCD00078602
PDSP1_001618
PDSP2_001602
AKOS040747631
CCG-205348
LP01275
SDCCGSBI-0051241.P002
5-methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
NCGC00016067-01
NCGC00016067-02
NCGC00016067-03
NCGC00016067-04
NCGC00016067-05
NCGC00016067-07
NCGC00094511-01
NCGC00094511-02
NCGC00094511-03
NCGC00261960-01
DA-70239
SMR000326902
HY-120296
CS-0077509
EU-0101275
U-101
L000080
SR-01000075287
SR-01000075287-1
Q27073993
5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]-propyl]-amino]-1,3-dimethyluracil
5-Methyl-6[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propylamino}-1,3,5-trimethyl-1H-pyrimidine-2,4-dione