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Buspirone

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Identification
Molecular formula
C21H31N5O2
CAS number
36505-84-7
IUPAC name
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione
State
State

At room temperature, Buspirone is in a solid state. Typically manufactured as medication in tablet form, it remains stable and effective in solid form under normal conditions.

Melting point (Celsius)
213.00
Melting point (Kelvin)
486.15
Boiling point (Celsius)
596.50
Boiling point (Kelvin)
869.65
General information
Molecular weight
385.51g/mol
Molar mass
385.5000g/mol
Density
1.2950g/cm3
Appearence

Buspirone typically appears as a white, crystalline powder. It is usually odorless and is often presented in tablet form for medicinal uses. The powder is fine and can be compressed into solid doses.

Comment on solubility

Solubility of 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione

The solubility of the compound 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione (C21H31N5O2) can be assessed based on its structural features and chemical properties. Generally, solubility in solvents may vary considerably due to:

  • Polarity: This compound contains both hydrophobic (the methoxyphenyl group) and hydrophilic (the amino group) components, suggesting it might have moderate solubility in polar solvents like water.
  • Functional Groups: The presence of multiple nitrogen atoms typically enhances solubility in polar solvents.
  • Conformation: The spatial arrangement of the piperazine ring can affect the overall solubility as well.

As a result, its solubility profile is likely to show:

  1. Better solubility in organic solvents: Such as alcohols, due to the non-polar characteristics of the aromatic system.
  2. Limited solubility in water: This might be observed, but further empirical testing is essential to define exact values.

In conclusion, while the solubility behavior of C21H31N5O2 is hypothesized based on its functional groups, definitive solubility data must be obtained through experimental analysis to better understand its practical applications.

Interesting facts

Exciting Facts about 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione

This compound is a fascinating example of a synthetic organic molecule with potential biological significance. Here are a few highlights that showcase its importance:


  • Pharmacological Potential: Compounds like this one often belong to a class of drugs known as antidepressants or anxiolytics, indicating they may interact with neurotransmitter systems in the brain.
  • Structural Complexity: The molecule is rich in functional groups, making it a great example of how different moieties can be combined to achieve specific biological effects. Its structural design includes a piperazine ring, which is common in pharmaceutical chemistry.
  • Synthetic Routes: The synthesis of such compounds often involves multi-step reactions that can be quite intricate, emphasizing the skillful manipulation of organic reactions in the lab.
  • Research Applications: This compound is likely to attract attention in the field of medicinal chemistry and pharmacology, where researchers are keen to discover new lead compounds for drug development.

In conclusion, 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione represents a promising chemical entity with intriguing possibilities in therapeutic applications. As one delves deeper into its chemistry and biological interactions, it can provide a gateway to understanding how subtle changes in chemical structure can lead to profound effects in biological systems.

Synonyms
urapidil
34661-75-1
Ebrantil
Eupressyl
Mediatensyl
Uraprene
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
B-66256
NSC 310405
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
NSC-310405
A78GF17HJS
6-(3-(4-(o-Methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil
MLS003115907
DTXSID9021425
NCGC00016066-07
Ebrantil (TN)
6-((3-(4-(o-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyluracil
2,4(1H,3H)-Pyrimidinedione, 6-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl-
Urapidilum
Urapidilum [INN-Latin]
6-[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
6-[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propylamino]-1,3-dimethyluracil
2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-
6-((3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
EINECS 252-130-4
CAS-64887-14-5
UNII-A78GF17HJS
Urapidil [INN:BAN:JAN]
BRN 0725782
Urapidil,(S)
6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
MFCD00133908
Urapidil (Standard)
Spectrum_001360
Tocris-1772
SpecPlus_000683
Lopac-U-100
URAPIDIL [INN]
URAPIDIL [JAN]
URAPIDIL [MI]
Prestwick0_000905
Prestwick1_000905
Prestwick2_000905
Prestwick3_000905
Spectrum2_001172
Spectrum3_001557
Spectrum4_000233
Spectrum5_001611
Urapidil (JP17/INN)
URAPIDIL [MART.]
URAPIDIL [WHO-DD]
2,4(1H,3H)-dione
Lopac0_001265
SCHEMBL48992
BSPBio_000750
BSPBio_003034
KBioGR_000925
KBioSS_001840
5-25-15-00402 (Beilstein Handbook Reference)
DivK1c_006779
SPECTRUM1503100
SPBio_001183
SPBio_002949
BPBio1_000826
CHEMBL279229
DTXCID501425
CHEBI:32278
GTPL13357
HY-B0716R
KBio1_001723
KBio2_001840
KBio2_004408
KBio2_006976
KBio3_002534
BCPP000025
HMS1922E11
BCP02494
HY-B0716
Tox21_110298
BDBM50237617
CCG-40329
NSC310405
s5965
STL454353
propylamino)-1,3-dimethylpyrimidine-
AKOS015896920
AC-8246
DB12661
FU34927
KS-5208
SDCCGSBI-0051232.P004
URACIL, 1,3-DIMETHYL-6-(3-(4-(o-METHOXYPHENYL)-1-PIPERAZINYL)PROPPYLAMINO)-
NCGC00016066-01
NCGC00016066-02
NCGC00016066-03
NCGC00016066-04
NCGC00016066-05
NCGC00016066-06
NCGC00016066-08
NCGC00016066-09
NCGC00016066-10
NCGC00016066-11
NCGC00016066-16
NCGC00016066-22
NCGC00025290-01
NCGC00025290-02
NCGC00025290-03
NCGC00025290-04
NCGC00025290-05
NCGC00178336-01
NCGC00178336-02
1,3-dimethyl-6-[(3-{4-[2-(methyloxy)phenyl]piperazin-1-yl}propyl)amino]pyrimidine-2,4(1H,3H)-dione
6-((3-(4-(2-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
SMR001831470
BCP0726000257
SBI-0051232.P003
CAS-34661-75-1
AB00514699
CS-0009600
NS00009232
U0085
6-(3-(4-(2-methoxyphenyl)piperazin-1-yl)
B66256
D01333
F15008
AB00053328_10
AB00053328_11
B 66256
L005359
Q418922
BRD-K73196317-001-02-7
BRD-K73196317-003-03-1
BRD-K73196317-003-07-2
BRD-K73196317-003-13-0
BRD-K73196317-003-14-8
BRD-K73196317-003-15-5
6-[3-[4-(2-Methoxyphenyl)piperazinyl]propylamino]-1,3-dimethyluracil
Uracil,3-dimethyl-6-[3-[4-(o-methoxyphenyl)-1-piperazinyl]proppylamino]-
Uracil, 1,3-dimethyl-6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-
2,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-
6-((3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione #
6-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Ebrantil, 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]- amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione