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Cloxacillin

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Identification
Molecular formula
C19H17Cl2N3O5S
CAS number
61-72-3
IUPAC name
6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

At room temperature, cloxacillin is a solid compound.

Melting point (Celsius)
178.50
Melting point (Kelvin)
451.65
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
476.32g/mol
Molar mass
476.8870g/mol
Density
1.4900g/cm3
Appearence

Cloxacillin appears as a white to off-white crystalline powder. It is practically odorless and has a bitter taste.

Comment on solubility

Solubility of 6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of the compound C19H17Cl2N3O5S is influenced by various factors due to its complex structure. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple polar functional groups, such as carboxylic acid and amine moieties, suggests that the compound may exhibit solubility in polar solvents like water.
  • Hydrophobic Regions: The dichlorophenyl ring contributes hydrophobic characteristics, potentially limiting solubility in purely aqueous environments.
  • Solvent Interaction: Solubility could be enhanced in mixed solvents that include both polar and non-polar components, allowing for better interaction with the hydrophobic segments.
  • pH Dependence: The carboxylic acid group in the compound could ionize in basic conditions, further promoting solubility in alkaline solutions.

In summary, while the compound may likely dissolve in polar solvents due to its functional groups, the overall solubility is a balance between its polar and non-polar characteristics. Understanding these interactions is essential for predicting its behavior in various environments.

Interesting facts

Interesting Facts about 6-[[3-(2,6-Dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This compound is a fascinating member of the family of isoxazole derivatives, known for their diverse biological activities and potential applications in pharmaceutical chemistry. Here are some intriguing aspects:

  • Pharmacological Properties: Compounds like this one are often investigated for their therapeutic potentials, particularly in the realm of anti-inflammatory and antimicrobial agents.
  • Structural Complexity: The structure showcases a unique bicyclic framework fused with a thiazolidine ring. This specific arrangement contributes to the compound's potential efficacy and interaction with biological targets.
  • Chlorine Substituents: The presence of dichloro groups at specific positions has been correlated with enhanced biological activity, making the study of chlorinated compounds crucial in medicinal chemistry.
  • Isoxazole Ring: Isoxazole derivatives are known for their ability to mimic natural biochemicals, which may provide insights into drug design and synthesis.
  • Synthetic Pathways: The synthesis of this compound typically involves intricate organic transformation techniques, showcasing the depth of knowledge required in modern synthetic chemistry.

As we explore the realms of organic synthesis, it's important to recognize the potential of such compounds not just for their existing applications, but for future discoveries in medicinal chemistry and drug development. Each new compound represents a pathway to understanding complex biological systems and potential therapeutic breakthroughs.

In the words of notable chemists, "The essence of chemistry is not in the molecules we create, but in the stories they tell through their interactions."

Synonyms
Maclicine
Oprea1_227571
CHEMBL1616891
R 13423
SCHEMBL11407716
DTXSID20859794
YFAGHNZHGGCZAX-UHFFFAOYSA-N
DB-047980
NS00009446
[2S-[2.alpha.,5.alpha.,6.beta.]]-6-[[[3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2.alpha.,5.alpha.,6.beta.)]-
6-(([3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid #
6-{[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid