Skip to main content

Flucloxacillin

ADVERTISEMENT
Identification
Molecular formula
C19H17ClFN3O5S
CAS number
1847-24-1
IUPAC name
6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State

At room temperature, flucloxacillin is a solid, particularly in its pure form as a crystalline powder. When formulated for pharmaceutical use, it may be found in solid forms such as tablets or capsules for oral administration, or as a powder for solution for injection or infusion.

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
453.87g/mol
Molar mass
453.9100g/mol
Density
1.5600g/cm3
Appearence

Flucloxacillin typically appears as a white or almost white crystalline powder. It may also be presented in the form of capsules or tablets, which are solid. The powder is characterized by its fine texture and lack of odor.

Comment on solubility

Solubility of 6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of a compound in a solvent is an important aspect that determines its behavior in various chemical processes. When examining the solubility of the compound C19H17ClFN3O5S, several factors come into play:

  • Polarity: The presence of functional groups such as amine and carboxylic acid often increases the polarity, allowing for potential solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvent molecules can significantly affect solubility. For this compound, both the amino and carboxylic groups may facilitate such interactions.
  • Structural Complexity: The bicyclic structure may affect how well the compound can interact with solvent molecules, potentially hindering solubility in some cases.
  • Substituent Effects: The presence of halogens, such as chlorine and fluorine, can affect the overall solubility due to their electronegative nature, which may influence the interactions between the compound and solvent.

It is essential to consider the surrounding environmental conditions, such as temperature and pH, as they can also play a critical role in the solubility profile of this compound.

In summary, while predicting solubility can be complex, the interactions between the compound’s functional groups and the solvent are key determinants. As with many other compounds, the solubility of this specific compound will likely showcase a range of behaviors depending on the solvent chosen.

Interesting facts

Interesting Facts about 6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This compound is a fascinating example of synthetic organic chemistry, illustrating the complexity and diversity of compound structures that can be created. Here are some engaging insights into this intriguing molecule:

  • Mechanism of Action: The unique structure of this compound suggests potential bioactivity, particularly in medicinal chemistry. The incorporation of both isoxazole and bicyclic elements implies interesting interactions with biological targets, potentially influencing enzyme activity or receptor binding.
  • Chirality: The compound includes chiral features, meaning that it can exist in different spatial arrangements. This chirality can affect how the compound interacts with biological systems, highlighting the importance of stereochemistry in drug design.
  • Fluorine Substituent: The presence of fluorine atoms, particularly in the context of pharmaceuticals, is well-known to enhance metabolic stability and bioavailability. This can lead to more effective therapeutic agents with reduced rates of degradation.
  • Isoxazole Ring: Isoxazole derivatives are recognized for their activity in various fields ranging from agriculture to medicine. The isoxazole ring contributes to the biological profile of this compound and can provide unique reactivity due to its electron-withdrawing nature.
  • Research Opportunities: The compound represents a potential subject for further research. Scientists may explore its synthesis, biological evaluation, and applications in drug development. Such investigations can lead to the discovery of novel therapeutic agents.

The combination of these features makes 6-[[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid an exciting subject for study, bridging both the realms of organic synthesis and pharmacology. As we continue to explore such compounds, we get closer to understanding their potential uses and mechanisms of action in various applications.

Synonyms
CHEMBL1622855
SCHEMBL14126462
DTXSID70859683
AKOS030241643
NS00001654
6-(((3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-{[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid