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Amoxicillin

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Identification
Molecular formula
C16H19N3O5S
CAS number
26787-78-0
IUPAC name
6-[(2-amino-2-phenyl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
State
State
At room temperature, amoxicillin is typically in a solid state, appearing as a white crystalline powder. It is generally stable in this form when kept in proper storage conditions to avoid degradation.
Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
365.41g/mol
Molar mass
365.4050g/mol
Density
1.6000g/cm3
Appearence

Amoxicillin appears as a white crystalline powder. It is slightly soluble in water and ethanol, and has no significant odor. The high polymorphism of its crystalline structure can lead to varying degrees of hydration, affecting the powder's specific appearance and texture.

Comment on solubility

Solubility of 6-[(2-amino-2-phenyl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

The solubility of this compound, C16H19N3O5S, can be influenced by various factors including its structural properties and the nature of solvents used. Understanding solubility is essential for applications in fields such as pharmaceuticals and biochemistry.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups such as -COOH and -NH2 suggests increased solubility in polar solvents, particularly water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility; this compound's structure likely allows for such interactions.
  • Temperature: Solubility can also vary with temperature—typically, an increase in temperature may increase solubility for solids.

In terms of practical application, one might observe that:

  • It could exhibit higher solubility in aqueous or alcohol solutions due to the presence of polar functional groups.
  • On the other hand, solubility in non-polar solvents may be limited as a result of its chemical structure.

In conclusion, the solubility of 6-[(2-amino-2-phenyl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid is expected to be influenced by its structural characteristics and the surrounding environment. As solubility is a critical parameter affecting biological and chemical behavior, it warrants careful consideration in both research and application domains.

Interesting facts

Exploring 6-[(2-amino-2-phenyl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

This fascinating compound, a member of the broad class of bicyclic compounds, stands out due to its unique structure and potential applications in medicinal chemistry. Here are some key points to consider:

  • Structural Complexity: The compound features a bicyclic structure which is important in drug design, providing multiple points of interaction with biological targets.
  • Thia Component: The presence of sulfur within the bicyclic framework introduces interesting electronic and steric properties that can enhance pharmacological activity.
  • Functional Groups: Notably, it incorporates both amino and carboxylic acid functional groups, which are crucial for biological activity and solubility in physiological environments.
  • Potential Applications: Compounds with such structural characteristics are often investigated for their potential as antibiotics or inhibitors, offering promising avenues in treating infections or diseases.
  • Analog Development: Scientists actively study analogs of this compound to further explore its biological capabilities and optimize the therapeutic effects while minimizing side effects.

As stated by eminent chemist Linus Pauling, “The best way to have a good idea is to have a lot of ideas.” In the spirit of innovation, compounds like this one offer rich fields for exploration. The interplay between its complex structure and potential applications in pharmacology reinforces the significance of ongoing research in chemical synthesis and drug discovery. Whether through enhancing existing molecules or designing new ones, the journey of uncovering the secrets held within such compounds remains one of the most exciting frontiers in chemistry.

Synonyms
Alpen
Guicitrine
Deripen
Wypicil
6-{[amino(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Ampen
AMPI
D-(-)-.alpha.-Aminobenzylpenicillin
Ampipenin, nt3
NCGC00018160-02
Pen A Oral
P 50
.alpha.-Aminobenzylpenicillin
SCHEMBL242460
CHEMBL1617921
D-(-)-.alpha.-Aminopenicillin
CHEBI:94334
DTXSID20859077
BCP25420
BHC17365
BBL016496
STK803647
AKOS000641681
AKOS022060556
6-[(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
LS-14499
NCI60_004295
SY076914
NS00000689
SR-01000318615
SR-01000318615-1
WLN: T45 ANV ESTJ CMVYZR& F1 F1 GVQ -D
6-D(-)-.alpha.-Aminophenylacetamido-penicillanic acid
BRD-A16754160-001-01-5
BRD-A16754160-236-01-7
Q27166159
6-(D-(-)-.alpha.-Aminophenylacetamido)penicillanic acid
Ampicillin acid;Aminobenzylpenicillin;Piperacillin EP Impurity A
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-dimethyl-7-oxo-, D-(-)-
D-(-)-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-dimethyl-7-oxo-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-dimethyl-7-oxo-, [2S-[2.alpha.,5.alpha.,6.beta.(S )]]-
6-[(2-amino-1-oxo-2-phenylethyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
7-(2-amino-2-phenyl-acetyl)amino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4carboxylic acid
856649-99-5
D-(-)-6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid