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5,7-Dichloro-8-hydroxyquinoline

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Identification
Molecular formula
C9H5Cl2NO
CAS number
130-16-5
IUPAC name
5,7-dichloroquinolin-8-ol
State
State

At room temperature, 5,7-Dichloro-8-hydroxyquinoline exists as a solid. Its crystalline nature and stability in solid form make it suitable for various industrial and pharmaceutical applications.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
441.00
Boiling point (Kelvin)
714.15
General information
Molecular weight
230.06g/mol
Molar mass
230.0560g/mol
Density
1.6450g/cm3
Appearence

5,7-Dichloro-8-hydroxyquinoline typically appears as a pale yellow to light brown crystalline solid. It is characterized by its powder form and distinct chemical structure, which includes two chlorine atoms and a hydroxyl group attached to a quinoline backbone.

Comment on solubility

Solubility of 5,7-Dichloroquinolin-8-ol (C9H5Cl2NO)

The solubility of 5,7-dichloroquinolin-8-ol, an intriguing compound with applications in various fields, can be characterized as follows:

  • Solvent Compatibility: This compound tends to exhibit variable solubility depending on the solvent used. It is generally soluble in organic solvents such as ethanol, dichloromethane, and dimethyl sulfoxide (DMSO).
  • Water Solubility: Its solubility in water is quite limited, making it relatively insoluble in aqueous solutions. This property may limit certain applications requiring aqueous formulations.
  • Influence of pH: The solubility can be affected by the pH of the solution. For example, acidic or basic conditions might enhance its solubility through protonation or deprotonation of functional groups.
  • Temperature Effects: As with many organic compounds, increasing the temperature may improve solubility, allowing better dissolution in solvents.

In summary, while 5,7-dichloroquinolin-8-ol does show promising solubility in various organic solvents, its limited solubility in water is a notable characteristic. Understanding these solubility properties is crucial for optimizing its use in research and industry applications.

Interesting facts

Interesting Facts about 5,7-Dichloroquinolin-8-ol

5,7-Dichloroquinolin-8-ol is a fascinating compound with a variety of applications and attributes that make it notable in the field of chemistry. This organic compound belongs to the class of quinolines, which are bicyclic aromatic compounds derived from benzopyridines. Here are some interesting aspects to consider:

  • Pharmaceutical Relevance: Quinolines, including 5,7-dichloroquinolin-8-ol, have shown potential in pharmaceuticals, particularly in the development of anti-malarial and anti-cancer drugs. The structure of this compound contributes to its biological activity.
  • Structure and Reactivity: The presence of chlorine atoms at the 5 and 7 positions of the quinoline ring enhances the electron-withdrawing properties of the compound, which can affect its reactivity and interactions with other molecules.
  • Research Applications: Scientists are interested in synthesizing derivatives of 5,7-dichloroquinolin-8-ol to explore new medicinal properties. Research on quinoline derivatives often aims at improving efficacy and reducing side effects in therapeutic contexts.
  • Environmental Considerations: Compounds such as 5,7-dichloroquinolin-8-ol also draw attention regarding their environmental impact. Understanding the degradation pathways of such chlorinated compounds is crucial for assessing their ecological footprint.
  • Analytical Techniques: Due to its aromatic character, this compound can be analyzed using various techniques, including chromatography and spectroscopy. Such methods help chemists understand its purity and concentration in various formulations.

In summary, 5,7-dichloroquinolin-8-ol is not just another chemical formula; it embodies a realm of research potential and application in modern science. As emphasized by numerous studies, the pursuit of exploring such compounds could lead to breakthroughs in medicine and environmental science.

Synonyms
chloroxine
773-76-2
5,7-Dichloroquinolin-8-ol
5,7-Dichloro-8-hydroxyquinoline
5,7-Dichloro-8-quinolinol
Capitrol
Chlorquinol
Dichloroxin
Quixalin
Chloroxyquinoline
Dichloroquinolinol
Dikhloroskin
Clofuzid
Endiaron
Dichlorohydroxyquinoline
Chlofucid
Quinolor
Quesyl
5,7-Dichlorooxine
5,7-Dichloroxine
8-QUINOLINOL, 5,7-DICHLORO-
Chlorohydroxyquinoline
5,7-Dichloro-8-oxyquinoline
Chloroxine [USAN]
5,7-Dichlor-8-hydroxychinolin
NSC 3904
CCRIS 5751
CHQ
NSC-3904
EINECS 212-258-3
UNII-2I8BD50I8B
MFCD00006786
BRN 0153606
2I8BD50I8B
DTXSID5022801
SQ 16401
CHEBI:59477
NSC3904
DTXCID202801
5,7-Dichloro-8-hydroquinoline
5-21-03-00286 (Beilstein Handbook Reference)
Chloroxine (USAN)
AS-229
dichloroquine
NCGC00095264-01
CHLOROXINE (MART.)
CHLOROXINE [MART.]
CAS-773-76-2
Capitrol Cream Shampoo
SR-01000747474
5,7-Dichlor-8-hydroxychinolin [German]
5,7-Dichloroquinolin-8-ol; Clioquinol Imp. B (EP); Clioquinol Impurity B
Capitrol (TN)
Spectrum_001434
CHLOROXINE [MI]
5,7-Dichloro-8-oxine
Spectrum2_000687
Spectrum3_001156
Spectrum4_000744
Spectrum5_001444
CHLOROXINE [VANDF]
8-Quinolinol,7-dichloro-
cid_2722
SCHEMBL3350
CHLOROXINE [WHO-DD]
Oprea1_486275
REGID_for_CID_2722
BSPBio_002711
KBioGR_001068
KBioSS_001914
MLS000681736
BIDD:GT0763
DivK1c_000578
SPECTRUM1503202
SPBio_000813
CHEMBL1200596
CHLOROXINE [ORANGE BOOK]
BDBM32147
HMS501M20
KBio1_000578
KBio2_001914
KBio2_004482
KBio2_007050
KBio3_002211
NINDS_000578
HMS1923K05
HMS2092N04
HMS2609A16
HMS3259E17
HMS3655G16
HMS3712O06
Pharmakon1600-01503202
Capitrol Cream Shampoo (Salt/Mix)
component of Capitrol Cream Shampoo
HY-B0295
5,7-Dichloro-8-quinolinol, 99%
Tox21_111494
AC9195
CCG-40039
NSC758398
s1839
STK075368
quinoline, 5,7-dichloro-8-hydroxy-
AKOS000271338
Tox21_111494_1
AC-4820
DB01243
FD34633
FH34160
NC00505
NSC-758398
IDI1_000578
UPCMLD0ENAT5752182:001
NCGC00095264-02
NCGC00095264-03
NCGC00095264-04
NCGC00095264-05
DA-62285
SMR000312779
SY016017
TG2-36-1
SBI-0051782.P002
D0412
NS00004348
SW198618-2
D03472
EN300-207135
AB00052323-08
AB00052323_09
AB00052323_10
SR-01000747474-2
SR-01000747474-3
BRD-K17075857-001-06-9
BRD-K17075857-001-16-8
BRD-K17075857-001-17-6
BRD-K17075857-001-18-4
Q12029435
F0918-0943
Z111781330
212-258-3
5,7-Dichloro-8-quinolinol; Chloroxine; 5,7-Dichloro-8-hydroxy; 5,7-Dichloro-8-hydroxy quinoline