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5,7-Dichloro-2-methyl-8-hydroxyquinoline

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Identification
Molecular formula
C10H7Cl2NO
CAS number
130-73-4
IUPAC name
5,7-dichloro-2-methyl-quinolin-8-ol
State
State

At room temperature, the compound is in a solid state. It is stable under normal conditions but should be handled with care to avoid unnecessary exposure or release into the environment.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
308.10
Boiling point (Kelvin)
581.25
General information
Molecular weight
264.08g/mol
Molar mass
264.1070g/mol
Density
1.4597g/cm3
Appearence

The compound is typically found as a crystalline powder with a yellowish color. It is not noted for being particularly hygroscopic but should be stored in a sealed container to avoid moisture uptake. The appearance of the solid is consistent, and it forms sharp crystals under the right conditions.

Comment on solubility

Solubility of 5,7-Dichloro-2-methyl-quinolin-8-ol

The solubility of 5,7-dichloro-2-methyl-quinolin-8-ol (C10H7Cl2NO) can greatly influence its application in various fields. This compound has certain characteristics that affect its solubility:

  • Polarity: The presence of the nitrogen atom and hydroxyl group generally increases polarity, suggesting that the compound may be more soluble in polar solvents.
  • Chlorine Atoms: The two chlorine substituents may enhance solubility in non-polar solvents, creating a unique balance.
  • Solvent Interaction: The compound's solubility can vary significantly in different solvents. For example, it may be soluble in dimethyl sulfoxide (DMSO) or methanol but less so in hydrocarbons.
  • Temperature Dependence: As with many organic compounds, increased temperature often leads to improved solubility, allowing for more effective dissolution in appropriate solvents.

To summarize, the solubility of 5,7-dichloro-2-methyl-quinolin-8-ol can be described as moderate, highly dependent on the nature of the solvent and the temperature. Understanding these factors is crucial for optimizing its use in practical applications.

Interesting facts

Interesting Facts about 5,7-Dichloro-2-methyl-quinolin-8-ol

5,7-Dichloro-2-methyl-quinolin-8-ol is a fascinating compound with a unique structure and significant applications in various fields. Here are some intriguing points regarding this chemical:

  • Quinoline Derivative: This compound is a derivative of quinoline, a class of compounds known for their aromatic properties and heterocyclic nature. Quinoline itself is an important core structure in many biologically active molecules.
  • Antimicrobial Activity: Compounds within the quinoline family, including this one, have been shown to exhibit antimicrobial properties, making them potential candidates for the development of new antibiotics.
  • Role in Pharmaceuticals: The dichloromethyl group provides enhanced reactivity, leading to the synthesis of various pharmaceuticals. This makes 5,7-dichloro-2-methyl-quinolin-8-ol a significant interest in medicinal chemistry.
  • Use in Research: Scientists often investigate such compounds for their interactions in biological systems, targeting mechanisms of action that could be leveraged to combat diseases.
  • Structure-Activity Relationship (SAR): Understanding how modifications to its structure impact its biological activity is a key focus, as it could lead to the development of more effective therapeutic agents.

As noted by chemists, "The subtle modifications in the structure of quinoline derivatives can lead to significant changes in their biological activity." The exploration of 5,7-dichloro-2-methyl-quinolin-8-ol not only reveals the importance of chlorinated compounds but also highlights the intricate relationship between chemical structure and biological function.

This compound serves as a reminder of the complexity of chemical research and its relevance in creating new treatments for health and disease.

Synonyms
Chlorquinaldol
72-80-0
5,7-Dichloro-8-hydroxyquinaldine
5,7-dichloro-2-methylquinolin-8-ol
Chloroquinaldol
5,7-Dichloro-8-hydroxy-2-methylquinoline
Clorquinaldol
5,7-Dichloro-2-methyl-8-quinolinol
Sterosan
5,7-Dichloro-8-quinaldinol
Chlorchinaldol
Siasteran
Siogene
Siosteran
Steroxin
Chlorchinaldolum
Chlorquinaldolum
Gyno-sterosan
Clorchinaldolo
8-QUINOLINOL, 5,7-DICHLORO-2-METHYL-
Hydroxydichloroquinaldine
5,7-Dichloro-2-methyl-8-hydroxyquinoline
Clorchinaldolo [DCIT]
Clorquinaldol [INN-Spanish]
Chlorquinaldolum [INN-Latin]
5,7-Dichloro-2-methyl-quinolin-8-ol
Chlorquinaldol [INN:BAN:DCF]
D6VHC87LLS
EINECS 200-789-3
MFCD00023984
NSC-755830
BRN 0156683
Chlorquinaldol (INN)
DTXSID3048998
CHEBI:74500
CHLORQUINALDOL [MI]
CHLORQUINALDOL [INN]
2-methyl-5,7-dichloro-8-hydroxyquinoline
CHLORQUINALDOL [MART.]
MLS002695929
CHLORQUINALDOL [WHO-DD]
DTXCID3028924
5-21-03-00346 (Beilstein Handbook Reference)
NSC 755830
NCGC00095795-04
Chlorchinaldine
SMR001549973
Clorquinaldol (INN-Spanish)
Chlorquinaldolum (INN-Latin)
CHLORQUINALDOL (MART.)
Chloquinan
Chlorchinaldin
Chlorguinaldon
Siogen
CHLORQUINALDOL, Chlorquinaldol (5,7-Dichloro-2-methyl-8-quinolinol)
CAS-72-80-0
UNII-D6VHC87LLS
Gynotherax
Vagisteran
Florabina
Saprosan
Siogenal
Siogeno
Siogenon
Siosept
Sterozan
Quesil
5,7 Dichloro 2 methyl 8 quinolinol
Hydroxydichloroquinaldinol
Spectrum2_000524
Spectrum3_001092
Spectrum4_001263
Chlorquinaldol (Standard)
cid_6301
Oprea1_721210
BSPBio_002764
KBioGR_001846
SPECTRUM212151
SCHEMBL301405
SPBio_000507
CHEMBL224325
BDBM76302
HY-B1360R
KBio3_001984
D08AH02
G01AC03
P01AA04
R02AA11
HMS3089A18
HMS3264I07
HMS3652H09
Pharmakon1600-00212151
BCP11865
HY-B1360
Tox21_113490
CCG-39580
NSC755830
s4192
STL502989
AKOS000119838
Tox21_113490_1
CS-4899
DB13306
FD40556
PS-7753
s10253
NCGC00095795-01
NCGC00095795-02
NCGC00095795-03
NCGC00095795-06
AC-29743
Quinolin-8-ol, 5,7-dichloro-2-methyl-
SY015325
SBI-0207012.P001
DB-055679
5,7-bis(chloranyl)-2-methyl-quinolin-8-ol
NS00021341
SW220230-1
EN300-19748
D07208
5,7-Dichloro-8-hydroxy-2-methylquinoline, 98%
AB00443827_06
AB00443827_07
SR-01000872737
Q1645622
SR-01000872737-1
BRD-K90374350-001-09-2
BRD-K90374350-001-10-0
Z104475058
5,7-Dichloro-8-hydroxyquinaldine 5,7-Dichloro-2-methyl-8-hydroxyquinoline
200-789-3