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Tetrahydrocannabinolic acid (THCA)

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Identification
Molecular formula
C22H30O4
CAS number
23978-85-0
IUPAC name
5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-1-one
State
State

THCA is a solid at room temperature. It is typically found in the unheated cannabis plant and becomes psychoactive THC through decarboxylation, which occurs when it is exposed to heat.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
149.30
Boiling point (Kelvin)
422.45
General information
Molecular weight
358.48g/mol
Molar mass
358.4770g/mol
Density
1.2000g/cm3
Appearence

THCA is typically a solid crystalline substance. In its pure form, it appears as a white powder, but it is commonly found in a dense, sticky resin or concentrated extract, known as resin glands or trichomes, on the cannabis plant.

Comment on solubility

Solubility of 5,6,10,10b-Tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-1-one (C22H30O4)

The solubility of complex organic compounds like 5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-1-one can be influenced by several factors. Understanding its solubility characteristics is essential for applications in pharmaceuticals, agrochemicals, and other industries.

Factors Influencing Solubility:

  • Polarity: The presence of multiple hydroxyl (–OH) groups in the compound suggests that it may exhibit some degree of hydrophilicity. Therefore, this compound is likely to be more soluble in polar solvents such as water compared to non-polar solvents.
  • Hydrophobic Regions: The long hydrophobic hydrocarbon chains present in the structure could hinder solubility in highly polar environments, suggesting a dual nature of solubility.
  • Temperature: Increased temperature generally enhances solubility for many compounds; hence, conducting solubility tests at varying temperatures can provide comprehensive insights.

In terms of practical applications, it is essential to note:

  • The compound may be sparingly soluble in water but could be readily soluble in organic solvents like ethanol, acetone, or chloroform.
  • Testing the solubility under various conditions (pH, temperature) will further clarify its behavior in solution.

In conclusion, while the structural complexity of C22H30O4 presents intriguing challenges regarding its solubility, understanding these nuances can lead to optimized usage across different chemical applications.

Interesting facts

Interesting Facts About 5,6,10,10b-Tetrahydroxy-3,4a,7,7,10a-Pentamethyl-3-vinyl-5,6,6a,8,9,10-Hexahydro-2H-Benzo[f]chromen-1-one

This intriguing compound, with a complex structure, falls under the category of flavonoids, which are known for their varied biological activities. Here are some fascinating insights about this compound:

  • Flavonoid Family: As part of the flavonoid class, this compound may exhibit characteristics similar to other flavonoids, such as antioxidant, anti-inflammatory, and antimicrobial properties.
  • Potential Health Benefits: Compounds like this have been studied for their ability to protect against diseases, including heart disease and cancer, making them a subject of interest in contemporary pharmacological research.
  • Synthetic Applications: The unique structure of this compound could serve as a precursor for synthesizing other important molecules in medicinal chemistry.
  • Natural Sources: Similar compounds can often be found in various plants, suggesting potential natural sources for extraction and study.
  • Structure-Activity Relationship: The distinct arrangement of the tetrahydroxy groups could potentially influence the biological activity, making it an excellent candidate for structure-activity relationship studies.

In the words of renowned chemist, "Chemistry is the doorway to the secrets of nature". This compound exemplifies that notion by revealing the hidden possibilities within natural compounds.

Ongoing research into compounds like this might uncover not only their roles in the plant kingdom but also their significant potential in therapeutic applications.

Synonyms
7-Desacetylforskolin
DEACETYLFORSKOLIN
64657-20-1