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5-(Piperazin-1-ylsulfonyl)isoquinoline

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Identification
Molecular formula
C13H15N3O2S
CAS number
23031-36-5
IUPAC name
5-piperazin-1-ylsulfonylisoquinoline
State
State

At room temperature, 5-(Piperazin-1-ylsulfonyl)isoquinoline is in a solid state. It appears as a crystalline powder which is white to off-white in color.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
479.60
Boiling point (Kelvin)
752.80
General information
Molecular weight
275.34g/mol
Molar mass
275.3350g/mol
Density
1.3600g/cm3
Appearence

5-(Piperazin-1-ylsulfonyl)isoquinoline appears as a white to off-white crystalline powder. It is solid at room temperature.

Comment on solubility

Solubility of 5-piperazin-1-ylsulfonylisoquinoline

The solubility of 5-piperazin-1-ylsulfonylisoquinoline (C13H15N3O2S) is an intriguing aspect that reflects its chemical behavior in various solvents. Understanding solubility can help predict the compound's interactions in biological systems and industrial applications.

Key Points on Solubility:

  • Polar vs Nonpolar Solvents: The presence of the piperazine and sulfonyl functional groups suggests that this compound may have better solubility in polar solvents, such as water, due to hydrogen bonding and dipole-dipole interactions.
  • Solvent Polarity: The overall solubility in different solvents can vary significantly. One might expect:
    • High solubility in water
    • Moderate to low solubility in organic solvents like hexane or toluene
  • Temperature Influence: As with many compounds, increased temperature can enhance solubility. This is particularly relevant in high-temperature applications.
  • pH Sensitivity: If the environment alters the pH, it could further influence the solubility due to changes in the ionization state of the functional groups involved.

In conclusion, while the solubility characteristics of 5-piperazin-1-ylsulfonylisoquinoline are promising for various applications, comprehensive experimental data are essential to fully characterize its solubility profile in different solvents.

Interesting facts

Interesting Facts about 5-Piperazin-1-ylsulfonylisoquinoline

5-Piperazin-1-ylsulfonylisoquinoline is a fascinating compound that belongs to the family of isoquinoline derivatives, which are known for their diverse biological activities. Here are some engaging points about this unique compound:

  • Biological Activity: Many isoquinoline derivatives are recognized for their pharmacological properties. Compounds like 5-piperazin-1-ylsulfonylisoquinoline have been studied for their potential as antidepressants and other therapeutic agents.
  • Synthetic Accessibility: The combination of piperazine and isoquinoline structures allows for straightforward synthetic routes in organic chemistry, making it an appealing target for researchers interested in designing novel pharmaceuticals.
  • Structure-Activity Relationship: This compound serves as a valuable model for studying the relationship between chemical structure and biological activity, aiding in the development of more effective drugs.
  • Research Applications: Its sulfonyl functional group can enhance solubility and biological activity, making it a key feature in medicinal chemistry research.
  • Multifunctional Potential: Beyond its biological applications, derivatives of isoquinoline including this compound could serve in materials science and catalysis, expanding their utility beyond pharmaceuticals.

In summary, 5-piperazin-1-ylsulfonylisoquinoline illustrates the intricate interplay of structure and function within organic compounds, promising exciting avenues for both academic research and drug development.

Synonyms
84468-24-6
5-(piperazin-1-ylsulfonyl)isoquinoline
1-(5-Isoquinolinesulfonyl)piperazine
ha-100
HA 100 (pharmaceutical)
Isoquinoline,5-(1-piperazinylsulfonyl)-
C-I-QP
C-1
1-(5-Isoquinolinylsulfonyl)piperazine
5-(piperazine-1-sulfonyl)isoquinoline
CHEMBL75773
Piperazine, 1-(5-isoquinolinylsulfonyl)-
DTXSID60233438
5-piperazin-1-ylsulfonylisoquinoline
Tocris-0543
1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride
MFCD00209852
5-(1-Piperazinylsulfonyl)isoquinoline
isoquinoline-5-sulfonamide 18
HA-100 2HCl
SCHEMBL1272907
BDBM15203
CHEBI:93271
BRD2751
DTXCID60155929
UPTYCYWTFGTCCG-UHFFFAOYSA-N
HA100
HMS3266K06
HMS3411C20
HMS3675C20
BRD-2751
1-(5-isoquinolinesulfonyl) piperazine
AKOS009604745
1-(5-Isoquinolinylsulfonyl)-piperazine
NCGC00024641-01
BS-45299
DA-73988
HY-100984
CS-0020664
D80372
EN300-151958
Isoquinoline-5-sulfonic acid piperazin-1 ylamide
SR-01000597700
1-(5-Isoquinolinesulfonyl)piperazine,dihydrochloride
SR-01000597700-1
BRD-K72462751-001-01-9
BRD-K72462751-001-02-7
Q27164985