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Phenytoin

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Identification
Molecular formula
C15H12N2O2
CAS number
57-41-0
IUPAC name
5-phenylimidazolidine-2,4-dione
State
State

Phenytoin is typically found in a crystalline solid state at room temperature.

Melting point (Celsius)
295.00
Melting point (Kelvin)
568.15
Boiling point (Celsius)
291.50
Boiling point (Kelvin)
564.70
General information
Molecular weight
252.27g/mol
Molar mass
252.2680g/mol
Density
1.2300g/cm3
Appearence

Phenytoin appears as a white, odourless, crystalline powder. It is slightly soluble in water and freely soluble in acetone, ethanol, and glacial acetic acid.

Comment on solubility

Solubility of 5-phenylimidazolidine-2,4-dione (C15H12N2O2)

The solubility of 5-phenylimidazolidine-2,4-dione, also known as phenylhydantoin, can be influenced by several factors, including temperature, solvent polarity, and molecular interactions. Generally, this compound is observed to have the following solubility characteristics:

  • Moderate solubility in organic solvents: It tends to dissolve well in solvents such as ethanol and methanol.
  • Limited solubility in water: Due to its relatively non-polar structure, 5-phenylimidazolidine-2,4-dione displays low solubility in water, which can be attributed to hydrogen bonding and solvation energy considerations.
  • Temperature dependency: As with many chemical compounds, higher temperatures can increase solubility, making it easier to dissolve the compound in suitable solvents.
  • Effect of pH: In aqueous environments, solubility may further change under acidic or basic conditions, as the protonation state of the compound can influence its overall solubility profile.

In summary, while 5-phenylimidazolidine-2,4-dione has moderate solubility in various organic solvents, its solubility in water is quite limited. Understanding these solubility properties is crucial for its application in various chemical and pharmaceutical contexts.

Interesting facts

Exploring 5-Phenylimidazolidine-2,4-dione

5-Phenylimidazolidine-2,4-dione, a fascinating compound in the realm of organic chemistry, offers a unique insight into the world of heterocycles and their applications. Here are some intriguing facts that highlight its importance:

  • Structural Innovation: The compound features a five-membered cyclic structure with both nitrogen and carbon atoms, making it a part of the imidazolidine family. This structure is crucial for its biological activity.
  • Biological Relevance: Compounds like 5-phenylimidazolidine-2,4-dione have been investigated for their potential use as pharmaceuticals. They may exhibit various biological activities, including anti-inflammatory and antioxidant properties.
  • Potential Applications: Owing to its unique structure, this compound can serve as a precursor for synthesizing more complex molecules, potentially leading to new drugs or materials in medicinal chemistry.
  • Research Interest: Scientists are continually exploring the behavior of such compounds in different conditions. As noted by researchers, "Understanding the reactivity of these nitrogen-containing heterocycles is key to developing next-generation therapeutics."
  • Synthesis Routes: The synthesis of 5-phenylimidazolidine-2,4-dione can involve various chemical reactions, which is a topic of keen interest for chemists looking to optimize production methods for efficiency and yield.

In summary, 5-phenylimidazolidine-2,4-dione is not just an ordinary compound; it represents the intersection of organic chemistry and pharmacology, encouraging ongoing research to unlock its full potential. As we continue to study its properties and applications, this compound could pave the way for exciting advancements in drug development and materials science.

Synonyms
5-Phenylhydantoin
89-24-7
5-phenylimidazolidine-2,4-dione
phenylhydantoin
Hydantoin, 5-phenyl-
2,4-Imidazolidinedione, 5-phenyl-
5-Phenyl-2,4-imidazolidinedione
ZQL8E3X7HK
NSC 27302
dl-5-phenylhydantoin
5-Phenylimidazoline-2,4-dione
EINECS 201-890-5
UNII-ZQL8E3X7HK
MFCD00037881
NSC 51847
NSC-27302
NSC-40885
NSC-51847
AI3-61187
MLS002639158
5-Phenyl-2,4-imidozolidinedione
DTXSID30883267
(+/-)-5-PHENYLHYDANTOIN
5-PHENYLHYDANTOIN [USP-RS]
27534-86-7
2, 5-phenyl-
5-PHENYLHYDANTOIN (USP-RS)
Maybridge4_002063
Oprea1_493755
SCHEMBL395878
DTXCID20893431
4-phenyl-4H-imidazole-2,5-diol
HMS1526N17
HMS3089L06
NSC27302
NSC40885
NSC51847
5-Phenyl-2,4-imidazolidinedione #
CCG-48023
STL360325
2, 5-phenyl-, (.+-.)-
AKOS001341666
AKOS016050358
FS-2657
NCGC00176961-01
PD065586
SMR000038135
DB-057120
CS-0099333
NS00041089
P0666
UNM000003518901
EN300-18239
SR-01000637598-1
BRD-A25516658-001-01-6
Q27888008
Z57474290