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SKF-81297

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Identification
Molecular formula
C16H17NO2
CAS number
104621-28-7
IUPAC name
5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
State
State

At room temperature, SKF-81297 is typically found in a solid state, specifically as a crystalline powder. It is generally stable under standard conditions of temperature and pressure.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
267.32g/mol
Molar mass
267.3220g/mol
Density
1.2500g/cm3
Appearence

SKF-81297, also known by its more systematic IUPAC name 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, generally appears as a white powder. The compound is usually synthesized in lab environments and often appears in its hydrochloride salt form for study and use in scientific research.

Comment on solubility

Solubility of 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol (C16H17NO2)

The solubility of 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol can be influenced by several factors, including its chemical structure and interactions with solvents. Here are some key points to consider:

  • Hydrophobic vs. Hydrophilic: The presence of aromatic rings in the compound indicates strong hydrophobic characteristics, which may limit its solubility in polar solvents.
  • Potential Solvent Interactions: The hydroxyl (-OH) groups present may enhance solubility in protic solvents like water due to hydrogen bonding.
  • Solubility Trends: Typically, compounds that contain both hydrophobic and hydrophilic components can have varied solubility; thus, this compound may be more soluble in organic solvents.
  • Concentration Dependence: The solubility may also depend on concentration; increases in temperature and agitation can enhance solubility to some extent.

In conclusion, while 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is likely to exhibit limited solubility in water, the degree of solubility may improve in polar organic solvents. These nuances underline the importance of considering both chemical structure and environmental conditions when assessing solubility.

Interesting facts

Interesting Facts About 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol

The compound known as 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol belongs to a fascinating class of compounds known for their versatility and biological significance. Here are some noteworthy points:

  • Chemical Structure: This compound showcases a unique bicyclic structure, which is a hallmark of many biologically active molecules. The incorporation of a benzene ring contributes to its aromaticity and stability.
  • Pharmacological Relevance: Compounds like this have been investigated for their potential therapeutic properties. They may exhibit activities such as neuroprotective and antidepressant effects, making them significant in medicinal chemistry.
  • Synthetic Applications: The synthesis of 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol serves as an excellent example for showcasing advanced methods in organic synthesis, particularly in the formation of complex amines.
  • Study of Isomerism: Like many organic compounds, this compound can exist in various isomeric forms, allowing for intriguing studies of isomer behavior and interactions in biological systems.

To quote a well-known chemist, “The beauty of chemistry lies in the ability to manipulate and create new compounds that can change our world.” This compound is a perfect illustration of that philosophy, contributing to our understanding of both chemistry and pharmacology.

Overall, 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol encapsulates the spirit of scientific discovery, bridging foundational chemical principles with cutting-edge research in medicinal applications.

Synonyms
67287-49-4
SKF 38393
SKF-38393
SK&F-38393
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
SKF-38393 free base
SKF38393
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-
BRN 1543419
R7TF327S2C
2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol
SK-38393
1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol
5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
CHEMBL286080
67287-49-4 (free base)
5-21-05-00258 (Beilstein Handbook Reference)
R(+)SKF38393
SK&F-383933
NCG-C00093856-01
SK-383933
6-PHENYL-4-AZOBICYCLO[5.4.0]UNDECA-7,9,11-TRIENE-9,10-DIOL
SKF-38393, (+/-)-
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
(+/-)-1-phenyl-2,3,4,5-tetrahydro-(1h)-3-benzazepine-7,8-diol
SK&F 38393
Biomol-NT_000034
(+/-)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol; (+/-)-SKF 38393; 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
SKF-38,393
UNII-R7TF327S2C
Lopac0_000436
BSPBio_002384
GTPL935
SCHEMBL469578
SPECTRUM1505101
BPBio1_001229
cid_147514
DTXSID10894836
CHEBI:110200
CHEBI:131793
CHEBI:131801
BCP16347
(RS)-SKF 38393
BDBM50004923
PDSP1_001524
PDSP2_001508
(A+/-)-SKF-38393 hydrochloride
AKOS040749511
CCG-204528
SDCCGSBI-0050421.P002
SKF 38,393
NCGC00015299-03
NCGC00015299-04
NCGC00015299-05
NCGC00015299-06
NCGC00015299-07
NCGC00015299-11
NCGC00024875-02
NCGC00024875-03
NCGC00024875-04
(+-)-SKF 38393
DB-217527
(+/-)-SKF-38393
(+/-)- SKF 38393
L000563
Q7390598
BRD-A88548664-001-02-3
BRD-A88548664-004-01-9
BRD-A88548664-004-02-7
rac-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol (SK&F 38393)
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol(SKF 38393)
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride(SKF 38393)
RS(+/-)SKF 383931-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
()-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol; ()-SKF 38393; 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine