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Brotizolam

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Identification
Molecular formula
C15H10ClNO4
CAS number
57801-81-7
IUPAC name
5-methyl-3,4-dihydro-1,4-benzodiazepin-2-one
State
State

Brotizolam is commonly found as a solid under room temperature conditions.

Melting point (Celsius)
192.50
Melting point (Kelvin)
465.65
Boiling point (Celsius)
398.10
Boiling point (Kelvin)
671.25
General information
Molecular weight
344.19g/mol
Molar mass
344.1870g/mol
Density
1.3000g/cm3
Appearence

Brotizolam is typically in the form of white to off-white crystalline powder. It is odorless and relatively stable under standard conditions.

Comment on solubility

Solubility of 5-methyl-3,4-dihydro-1,4-benzodiazepin-2-one (C15H10ClNO4)

The solubility of 5-methyl-3,4-dihydro-1,4-benzodiazepin-2-one in various solvents can be quite notable due to its molecular structure and the presence of functional groups. Generally, this compound exhibits a degree of solubility in:

  • Organic solvents: It is commonly soluble in polar organic solvents like methanol and ethanol.
  • Aqueous solutions: The solubility in water is limited, suggesting that it is partially soluble due to the hydrophobic benzodiazepine ring structure.
  • Acidic conditions: Under acidic conditions, the compound may exhibit increased solubility due to protonation of nitrogen atoms, which can enhance interactions with water.

This behavior can be encapsulated in the saying, “Like dissolves like,” as the non-polar sections of the molecule interact poorly with water. The overall solubility can be influenced by:

  1. Temperature: Increased temperature may enhance solubility.
  2. pH of the solvent: Variation in pH can change solubility by affecting ionization.
  3. Presence of other solutes: Certain solutes may facilitate or hinder solubility through various interactions.

In conclusion, the solubility of 5-methyl-3,4-dihydro-1,4-benzodiazepin-2-one is multifaceted and heavily reliant on the environment, illustrating the importance of solvent choice in chemical applications.

Interesting facts

Interesting Facts about 5-Methyl-3,4-Dihydro-1,4-Benzodiazepin-2-One

5-Methyl-3,4-dihydro-1,4-benzodiazepin-2-one, a member of the benzodiazepine family, offers a range of intriguing insights into its chemistry and application. Known primarily for its therapeutic benefits, this compound has gained attention for its contribution to the field of pharmacology. Here are some notable points:

  • Pharmacological Importance: Benzodiazepines are widely recognized for their anxiolytic, anticonvulsant, and sedative effects. They interact with the GABAA receptor, enhancing the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which leads to an overall calming effect on the central nervous system.
  • Molecular Flexibility: The dihydro form of this compound contributes to its molecular flexibility, which can influence its interaction with biological systems. This flexibility may result in varied pharmacological profiles, making it a target for further research.
  • Synthetic Pathways: The synthesis of 5-methyl-3,4-dihydro-1,4-benzodiazepin-2-one often involves complex multistep reactions. Understanding these pathways is crucial for chemists seeking to optimize yield and purity in pharmaceutical production.
  • Research Potential: Researchers are continually investigating benzodiazepines, including this compound, for their potential in treating anxiety disorders, insomnia, and other related conditions. Its unique structure may lead to the development of novel therapeutic agents that minimize side effects associated with traditional benzodiazepines.
  • Structural Features: The modification at the 5-position with a methyl group may play a key role in the activity and selectivity of the compound. This highlights the delicate balance between structural variations and biological activity.

In summary, 5-methyl-3,4-dihydro-1,4-benzodiazepin-2-one stands out not only for its pharmacological effects but also for its intricate chemistry. As research continues to uncover new insights about this compound, its importance within the scientific community remains significant. In the words of a renowned chemist, "Molecular understanding leads to revolutionary treatments."