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Thymine

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Identification
Molecular formula
C5H6N2O2
CAS number
65-71-4
IUPAC name
5-methyl-1H-pyrimidine-2,4-dione
State
State
Thymine primarily exists as a solid at room temperature. It is stable under standard conditions.
Melting point (Celsius)
316.00
Melting point (Kelvin)
589.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
126.11g/mol
Molar mass
126.1130g/mol
Density
1.2324g/cm3
Appearence

Thymine is a white crystalline solid. It is often encountered as a part of nucleic acids where it forms base pairs with adenine.

Comment on solubility

Solubility of 5-methyl-1H-pyrimidine-2,4-dione

The solubility of 5-methyl-1H-pyrimidine-2,4-dione (C5H6N2O2), commonly known as a derivative of pyrimidine, plays a crucial role in its applications in chemical synthesis and pharmaceuticals. Understanding its solubility characteristics can provide insights into its behavior in various solvent systems.

Key Points on Solubility:

  • Polar Nature: Due to the presence of carbonyl (C=O) and amino (NH) groups, this compound exhibits polar characteristics, which can lead to solubility in polar solvents.
  • Solvent Compatibility: It is generally soluble in water and organic solvents like methanol and ethanol, making it versatile for chemical reactions.
  • Temperature Influence: The solubility tends to increase with temperature, allowing better dissolution in solutions during reactions.
  • pH Sensitivity: The solubility can also be pH-dependent— ionization of the amino group may enhance solubility in alkaline conditions.

As the saying goes, “like dissolves like,” and this principle is particularly applicable to 5-methyl-1H-pyrimidine-2,4-dione. By understanding its solubility profiles in different solvents, one can effectively manipulate its use in various chemical processes.

Interesting facts

5-Methyl-1H-pyrimidine-2,4-dione: An Overview

5-Methyl-1H-pyrimidine-2,4-dione, commonly referred to as a derivative of pyrimidine, is a remarkable compound with various intriguing properties. This molecule is noteworthy not only for its structural features but also for its applications across different fields.

Key Characteristics and Applications

  • Biological Significance: This compound plays a crucial role in the field of medicinal chemistry. It is often studied for its potential as a building block in the synthesis of pharmaceuticals.
  • Aromatic Nature: As a pyrimidine derivative, it exhibits aromatic characteristics, making it a candidate for various organic reactions and syntheses.
  • Research in Agricultural Chemistry: Its derivatives are sometimes explored in agriculture, particularly for their use in pesticide formulation due to their effective bioactivity.
  • Analytical Applications: The compound is also utilized in analytical chemistry, particularly in the development of sensors and as a reagent in biochemical assays.

Interesting Facts

Here are some engaging points about 5-methyl-1H-pyrimidine-2,4-dione:

  • This compound is a part of a larger family of heterocycles, which are known for their diverse functionalities and versatile behavior in organic reactions.
  • In literature, the pyrimidine ring has been cited as a "gateway to countless biologically active compounds," highlighting the importance of such compounds in drug design.
  • As a chemical compound, it showcases the beauty of organic chemistry, where slight modifications in structure can lead to vast differences in function and application.
  • The methyl group attached at position 5 influences its reactivity and stability, making it a valuable component in organic synthesis.

In conclusion, 5-methyl-1H-pyrimidine-2,4-dione exemplifies the fascinating intersection of chemistry, biology, and even materials science. Its study not only enhances our understanding of pyrimidine derivatives but also inspires innovation in developing new therapeutic agents and agricultural solutions.

Synonyms
thymine
65-71-4
5-methyluracil
2,4-Dihydroxy-5-methylpyrimidine
Thymin
5-methylpyrimidine-2,4(1H,3H)-dione
Thymine anhydrate
2,4(1H,3H)-Pyrimidinedione, 5-methyl-
5-Methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Thymin (purine base)
5-methyl-1H-pyrimidine-2,4-dione
5-methyl-2,4(1H,3H)-pyrimidinedione
5-Methyl Uracil
CCRIS 5584
CHEBI:17821
UNII-QR26YLT7LT
QR26YLT7LT
AI3-25479
NSC14705
EINECS 200-616-1
MFCD00006026
NSC 14705
5-methylpyrimidine-2,4-diol
5-Methylpyrimidine-2,4-dione
4-Hydroxy-5-methylpyrimidin-2(1H)-one
DTXSID4052342
NSC-14705
CHEMBL993
5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)
123430-67-1
153445-43-3
DTXCID4030914
5-Methyl-2,4-dihydroxypyrimidine
thymine-d4
NSC-168663
Thy
2792-47-4
3059-73-2
THYMINE (USP IMPURITY)
THYMINE [USP IMPURITY]
Thymine-t
5 Methyluracil
Thymine (VAN)
(3H)Methylthymidine
Methyl-3H thymidine
ZIDOVUDINE IMPURITY C (EP IMPURITY)
ZIDOVUDINE IMPURITY C [EP IMPURITY]
Thymine (8CI)
Zidovudine Impurity C
5-methyl-uracil
Thymine,(S)
Thymine (Standard)
200496-79-3
Thymine, >=99%
THYMINE [MI]
THYMINE [WHO-DD]
STAVUINE IMPURITY A
Epitope ID:167476
SCHEMBL5235
2,4-Dihydroxy-5-methylpyrimidine; 5-Methyluracil
2,4(1H,3H)-Pyrimidinedione, 5-methyl- (9CI)
4(1H)-Pyrimidinone, 2-hydroxy-5-methyl- (9CI)
4(3H)-Pyrimidinone, 2-hydroxy-5-methyl- (9CI)
69497-78-5
5-Methyl-2,4-dioxypyrimidine
2.6-Dioxy-5-methyl-pyrimidin
GTPL4581
SCHEMBL15496760
SCHEMBL16356870
WLN: T6N CNJ BQ DQ E1
2,4(1H,3H)-Pyrimidinedione, 5-methyl-, labeled with tritium
AIA49679
BCP22973
HY-W010450R
TCA94198
2,3H)-Pyrimidinedione, 5-methyl-
Tox21_303929
BDBM50134397
s9382
STL280241
STL477641
STAVUINE IMPURITY A [WHO-IP]
AKOS000120923
AKOS002337369
AC-7756
CCG-266101
CS-W011166
DB03462
FT06260
HY-W010450
SB57778
ZIDOVUDINE IMPURITY C [WHO-IP]
CAS-65-71-4
CID 5274265
NCGC00357169-01
SY014896
Thymine, Vetec(TM) reagent grade, 99%
2(1H)-Pyrimidinone, 4-hydroxy-5-methyl-
4(1H)-Pyrimidinone, 2-hydroxy-5-methyl-
4(3H)-Pyrimidinone, 2-hydroxy-5-methyl-
DB-016098
DB-268941
DB-268967
DB-272085
DB-272203
pyrimidine-2,4(1H,3H)-dione, 5-methyl-
NS00001295
T0234
EN300-21969
C00178
Thymine, suitable for cell culture, BioReagent
2(1H)-PYRIMIDINONE, 6-HYDROXY-5-METHYL-
Q171973
SR-01000945223
SR-01000945223-1
036B9F1D-9B61-4CED-967C-BF1DA180E5C2
F0001-1753
Z147641104
InChI=1/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9
200-616-1
691841-57-3