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5-methoxy-1-phenyl-pyridazin-1-ium-4-amine

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Identification
Molecular formula
C12H13N3O
CAS number
189574-82-9
IUPAC name
5-methoxy-1-phenyl-pyridazin-1-ium-4-amine
State
State

The compound is typically in a solid state at room temperature. It is stable under normal conditions, but it should be protected from light and moisture to maintain its integrity.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
201.25g/mol
Molar mass
201.2300g/mol
Density
1.2500g/cm3
Appearence

It appears as a crystalline solid with a white to slightly off-white coloration. The crystals may form as either plates or needles depending on the method of crystallization used.

Comment on solubility

Solubility of 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine (C12H13N3O)

The solubility of 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine is an intriguing aspect that merits attention due to the compound's unique structure. This compound contains a pyridazinium moiety, which can influence its interactions with solvents.

Key Factors Influencing Solubility:

  • Polarity: The presence of the methoxy (-OCH3) group can enhance solubility in polar solvents, particularly in water and alcohols.
  • Ionization: As a quaternary ammonium salt, the compound is likely to exhibit good solubility in polar protic solvents due to its ionic nature.
  • Hydrogen Bonding: Interaction with solvation molecules via hydrogen bonding can further increase the solubility.

It is commonly observed that compounds like 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine showcase differing solubility behaviors in various systems, often dissolving readily in:

  • Water
  • Ethanol
  • Dimethyl sulfoxide (DMSO)

However, the solubility can be significantly lower in non-polar solvents such as hexane or chloroform, where the lack of polarity limits interaction with the compound. In summary, the solubility of 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine presents an excellent example of how structural components like functional groups and ionic characteristics can dictate solubility properties, making it essential for applications in medicinal chemistry and materials science.

Interesting facts

Interesting Facts about 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine

5-methoxy-1-phenyl-pyridazin-1-ium-4-amine is a fascinating compound that showcases the unique intersection of organic chemistry and pharmacology. Here are some intriguing aspects to consider:

  • Structural Diversity: The compound features a pyridazine ring, which is a six-membered aromatic ring containing two nitrogen atoms. This structural characteristic significantly impacts its reactivity and biological activity.
  • Potential Biological Activity: Compounds in the pyridazin class have been investigated for various biological activities, including anti-inflammatory, analgesic, and antibacterial properties. This raises the potential for 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine to exhibit similar pharmacological effects.
  • Methoxy Group Influence: The presence of the methoxy group can enhance solubility in organic solvents and may also influence the compound's ability to penetrate biological membranes, potentially increasing its efficacy in therapeutic applications.
  • Research Significance: Ongoing studies in medicinal chemistry focus on optimizing such compounds for the development of drugs that can target specific pathways in disease mechanisms. Researchers often evaluate how minor modifications can enhance efficacy and reduce side effects.
  • Emerging Applications: As scientists explore new avenues in drug discovery, pyridazine derivatives like this compound may find roles in treating diseases, including certain cancers and neurodegenerative disorders.

In the words of a celebrated chemist, “Chemistry is the study of transformation, and these compounds are the keys to new worlds of possibility.” The exploration of 5-methoxy-1-phenyl-pyridazin-1-ium-4-amine may very well lead to innovative solutions in health and medicine.